JOB SUMMARY
Iambic Therapeutics is seeking an Associate Medical Director or Medical Director to join its growing Clinical Development team. This position will be responsible for study execution and oversight of a clinical program currently in phase 1, as well as supporting pipeline programs that are in the preparation phase for IND submission. In addition to providing medical oversight for the phase 1 clinical trial, ensuring patient safety, regulatory compliance and scientific integrity, this individual will also contribute to the clinical program strategy and execution.
KEY RESPONSIBILITIES
Serve as the medical monitor for assigned clinical trials, providing medical and scientific expertise throughout the study lifecycle.
Work closely with other functional areas within Research and Development (clinical operations, regulatory sciences, data management, biostatistics, clinical pharmacology, nonclinical) to facilitate the execution of clinical trials and ensure that high standards of study conduct are met
Ensure participant safety by reviewing adverse events (AEs), serious adverse events (SAEs) and protocol deviations collaborate with pharmacovigilance to assess safety signals across the study
Provide guidance on patient eligibility and protocol adherence
Contribute to preparation of study-related documents including study protocols and amendments, Investigator Brochures (IBs), informed consent forms (ICFs), and clinical study reports (CSRs)
Review and interpret clinical trial data, ensuring accuracy and consistency in the safety, efficacy and other data
Support interactions with regulatory agencies, including preparation of documents for submission and participation at regulatory meetings
Establish strategic partnerships with KOLs, centers of excellence, and patient advocacy organizations
Develop content for advisory board meetings
Prepare abstracts and presentations for scientific symposia and manuscripts for publication in high impact peer reviewed journals
Keep up to date on standard of care and experimental therapies in relevant clinical areas through familiarity with literature, attendance at meetings, conventions and professional associations
QUALIFICATIONS
MD or PharmD with clinical oncology experience as well as experience in biotech/pharma oncology drug development is preferred. PhD with a minimum of 3 years of biotech or pharmaceutical experience in oncology drug development.
Experience as a medical monitor on a clinical trial, including patient eligibility review, site interaction to oversee protocol adherence, protocol deviation review, clinical data review and cleaning activities, coding
Experience in executing on clinical studies, including interactions with regulatory agencies
Excellent written and verbal communication skills
Ability to work effectively in cross functional teams with internal and external partners
Excellent organizational and time management skills with strong attention to detail, and proven ability to handle multiple tasks efficiently and effectively.
Creative problem-solving skills with proven ability to act in a proactive manner
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nIambic Therapeutics is seeking an Associate Medical Director or Medical Director to join its growing Clinical Development team. This position will be responsible for study execution and oversight of a clinical program currently in phase 1, as well as supporting pipeline programs that are in the preparation phase for IND submission. In addition to providing medical oversight for the phase 1 clinical trial, ensuring patient safety, regulatory compliance and scientific integrity, this individual will also contribute to the clinical program strategy and execution. \n\n\n\nKEY RESPONSIBILITIES\n\n - Serve as the medical monitor for assigned clinical trials, providing medical and scientific expertise throughout the study lifecycle.\n\n - Work closely with other functional areas within Research and Development (clinical operations, regulatory sciences, data management, biostatistics, clinical pharmacology, nonclinical) to facilitate the execution of clinical trials and ensure that high standards of study conduct are met\n\n - Ensure participant safety by reviewing adverse events (AEs), serious adverse events (SAEs) and protocol deviations collaborate with pharmacovigilance to assess safety signals across the study\n\n - Provide guidance on patient eligibility and protocol adherence\n\n - Contribute to preparation of study-related documents including study protocols and amendments, Investigator Brochures (IBs), informed consent forms (ICFs), and clinical study reports (CSRs)\n\n - Review and interpret clinical trial data, ensuring accuracy and consistency in the safety, efficacy and other data\n\n - Support interactions with regulatory agencies, including preparation of documents for submission and participation at regulatory meetings\n\n - Establish strategic partnerships with KOLs, centers of excellence, and patient advocacy organizations\n\n - Develop content for advisory board meetings\n\n - Prepare abstracts and presentations for scientific symposia and manuscripts for publication in high impact peer reviewed journals\n\n - Keep up to date on standard of care and experimental therapies in relevant clinical areas through familiarity with literature, attendance at meetings, conventions and professional associations\n\n\n\nQUALIFICATIONS\n\n - MD or PharmD with clinical oncology experience as well as experience in biotech/pharma oncology drug development is preferred. PhD with a minimum of 3 years of biotech or pharmaceutical experience in oncology drug development.\n\n - Experience as a medical monitor on a clinical trial, including patient eligibility review, site interaction to oversee protocol adherence, protocol deviation review, clinical data review and cleaning activities, coding\n\n - Experience in executing on clinical studies, including interactions with regulatory agencies\n\n - Excellent written and verbal communication skills\n\n - Ability to work effectively in cross functional teams with internal and external partners\n\n - Excellent organizational and time management skills with strong attention to detail, and proven ability to handle multiple tasks efficiently and effectively.\n\n - Creative problem-solving skills with proven ability to act in a proactive manner\n\n \n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$216K – $310K • Multiple Ranges","scrapeableCompensationSalarySummary":"$216K - $310K","compensationTiers":[{"id":"858da93e-53a1-453f-b1e7-f2e031304189","tierSummary":"$216K – $270K","title":"Associate Medical Director","additionalInformation":null,"components":[{"id":"c23df135-05f0-4c56-b89c-0aa2937a4f2e","summary":"$216K – $270K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":216000,"maxValue":270000}]},{"id":"1e5ebe49-5108-4b24-9967-dc9205116532","tierSummary":"$248K – $310K","title":"Medical Director","additionalInformation":null,"components":[{"id":"35654102-3b28-4463-bd7d-543ca1215d31","summary":"$248K – $310K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":248000,"maxValue":310000}]}],"summaryComponents":[{"minValue":216000,"maxValue":310000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"896bd303-842f-4e16-973e-0ba4e76d462f","title":"Sr Associate Scientist I or II, Medicinal Chemistry ","department":"Science","team":"Chemistry","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-04-02T22:35:52.854+00:00","isListed":true,"isRemote":false,"workplaceType":"OnSite","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/896bd303-842f-4e16-973e-0ba4e76d462f","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/896bd303-842f-4e16-973e-0ba4e76d462f/application","descriptionHtml":"JOB SUMMARY
We are seeking a highly skilled and motivated Senior Associate Scientist to join the Chemistry team at Iambic Therapeutics headquarters in San Diego. This position offers the opportunity to work within a dynamic, cross-functional environment, collaborating closely with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning researchers, and software engineers throughout all stages of discovery, from hit identification and lead optimization through candidate selection. This is a laboratory-based Associate Scientist position that requires strong technical expertise in organic synthesis, catalysis, and medicinal chemistry, as well as hands-on experience in the drug discovery process and a demonstrated “drug hunter” mindset.
KEY RESPONSIBILITIES
Design, synthesize, purify, and characterize chemical compounds (10 mg–5 g scale) using modern analytical techniques such as LCMS, HPLC, and NMR, employing both individual and automated parallel synthesis approaches.
Identify and optimize reaction conditions using screening kits and other streamlined methodologies.
Collaborate with the high-throughput experimentation team to ensure the successful execution of parallel chemistry experiments.
Analyze biological and ADME-PK data using cheminformatics tools and contribute to data-driven discussions and strategic planning.
Partner with computational chemists to leverage machine learning insights for efficient execution of the design–make–test cycle and platform development.
Present results to project teams and senior leadership, clearly communicating data, implications, and recommendations.
QUALIFICATIONS
BS in Chemistry with 5+ years experience (pharma/biotech) or MS in Chemistry with 3+ years experience (pharma/biotech).
Proven skills in multi-step organic synthesis, reaction optimization, SAR analysis, and scientific presentation.
Ability to thrive in a fast-paced, highly collaborative research environment.
Availability to work onsite in San Diego.
PREFERRED QUALIFICATIONS
Prior exposure to high-throughput experimentation.
Familiarity with ADME-PK principles.
5+ years of experience contributing to drug discovery projects.
Experience with molecular modeling and structure-based drug design
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking a highly skilled and motivated Senior Associate Scientist to join the Chemistry team at Iambic Therapeutics headquarters in San Diego. This position offers the opportunity to work within a dynamic, cross-functional environment, collaborating closely with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning researchers, and software engineers throughout all stages of discovery, from hit identification and lead optimization through candidate selection. This is a laboratory-based Associate Scientist position that requires strong technical expertise in organic synthesis, catalysis, and medicinal chemistry, as well as hands-on experience in the drug discovery process and a demonstrated “drug hunter” mindset.\n\n\n\nKEY RESPONSIBILITIES\n\n - Design, synthesize, purify, and characterize chemical compounds (10 mg–5 g scale) using modern analytical techniques such as LCMS, HPLC, and NMR, employing both individual and automated parallel synthesis approaches.\n\n - Identify and optimize reaction conditions using screening kits and other streamlined methodologies.\n\n - Collaborate with the high-throughput experimentation team to ensure the successful execution of parallel chemistry experiments.\n\n - Analyze biological and ADME-PK data using cheminformatics tools and contribute to data-driven discussions and strategic planning.\n\n - Partner with computational chemists to leverage machine learning insights for efficient execution of the design–make–test cycle and platform development.\n\n - Present results to project teams and senior leadership, clearly communicating data, implications, and recommendations.\n\n\n\nQUALIFICATIONS\n\n - BS in Chemistry with 5+ years experience (pharma/biotech) or MS in Chemistry with 3+ years experience (pharma/biotech).\n\n - Proven skills in multi-step organic synthesis, reaction optimization, SAR analysis, and scientific presentation.\n\n - Ability to thrive in a fast-paced, highly collaborative research environment.\n\n - Availability to work onsite in San Diego.\n\nPREFERRED QUALIFICATIONS\n\n - Prior exposure to high-throughput experimentation.\n\n - Familiarity with ADME-PK principles.\n\n - 5+ years of experience contributing to drug discovery projects.\n\n - Experience with molecular modeling and structure-based drug design\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$84K – $120K • Multiple Ranges","scrapeableCompensationSalarySummary":"$84K - $120K","compensationTiers":[{"id":"50ad8dd6-73c2-43dd-93b1-d2e292c7fbdf","tierSummary":"$84K – $105K","title":"Sr Associate Scientist I","additionalInformation":null,"components":[{"id":"4230984f-a2e8-4dc7-bcf5-f253941d44cf","summary":"$84K – $105K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":84000,"maxValue":105000}]},{"id":"66191dc2-e5f0-4e80-beeb-5ca423ff6b36","tierSummary":"$96K – $120K","title":"Sr Associate Scientist II","additionalInformation":null,"components":[{"id":"00900738-6a83-4937-a902-3ac9dab7423a","summary":"$96K – $120K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":96000,"maxValue":120000}]}],"summaryComponents":[{"minValue":84000,"maxValue":120000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"c6d254ff-4674-452f-a085-96cfd8141f9d","title":"Principal Scientist, Medicinal Chemistry","department":"Science","team":"Chemistry","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-04-15T00:47:21.189+00:00","isListed":true,"isRemote":null,"workplaceType":null,"address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/c6d254ff-4674-452f-a085-96cfd8141f9d","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/c6d254ff-4674-452f-a085-96cfd8141f9d/application","descriptionHtml":"JOB SUMMARY
We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.
This position is on-site at our San Diego Headquarters.
KEY RESPONSIBILITIES
Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles.
Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques.
Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions
Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules
Communicate project updates clearly and effectively to the broader team and key stakeholders
Work as a member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork
QUALIFICATIONS
BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry
Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 15+ years’ experience, M.S. with 12+ years’ experience or Ph.D. with 8+ years’ experience.
Proven track record of success in advancing programs from leads to advanced candidates.
Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.
Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
Practical experience and working knowledge of target protein degradation and associated modalities (molecular glues, PROTACS)
Ability to integrate multiple R&D disciplines into a successful strategic project plan
Experience working with computational chemists as part of project team in design of drug targets is required
Strong interpersonal, communication, time management, and leadership skills
Creative problem solving and management of relationships with several stakeholders within and beyond the company
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges, as well as proactively interfacing with diverse teams working on automated experimentation, AI-driven molecular generation, property predictions, and bioassay data generation.\n\nThis position is on-site at our San Diego Headquarters.\n\nKEY RESPONSIBILITIES\n\n - Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles.\n\n - Execute on high quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations and implementing innovative techniques.\n\n - Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions\n\n - Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities\n\n - Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules\n\n - Communicate project updates clearly and effectively to the broader team and key stakeholders\n\n - Work as a member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork\n\nQUALIFICATIONS\n\n - BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry\n\n - Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting and a B.S. with 15+ years’ experience, M.S. with 12+ years’ experience or Ph.D. with 8+ years’ experience.\n\n - Proven track record of success in advancing programs from leads to advanced candidates.\n\n - Extensive experience in lead compound optimization for potency, selectivity, ADME and PK.\n\n - Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents\n\n - Practical experience and working knowledge of target protein degradation and associated modalities (molecular glues, PROTACS)\n\n - Ability to integrate multiple R&D disciplines into a successful strategic project plan\n\n - Experience working with computational chemists as part of project team in design of drug targets is required\n\n - Strong interpersonal, communication, time management, and leadership skills\n\n - Creative problem solving and management of relationships with several stakeholders within and beyond the company\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.\n\n\n\n","compensation":{"compensationTierSummary":"$152K – $190K","scrapeableCompensationSalarySummary":"$152K - $190K","compensationTiers":[{"id":"703d0190-a688-49dd-a685-80eb6831bb2a","tierSummary":"$152K – $190K","title":"Principal Scientist","additionalInformation":null,"components":[{"id":"cece6b44-135d-4e8d-bf0c-8fdd40ed7330","summary":"$152K – $190K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":152000,"maxValue":190000}]}],"summaryComponents":[{"compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":152000,"maxValue":190000}]}},{"id":"0d5b653b-f9c5-4adc-b328-68574caf9c9b","title":"Senior Clinical Trial Manager, Clinical Operations","department":"Clinical","team":"Clinical Operations","employmentType":"FullTime","location":"Remote - US","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-08-18T20:47:37.939+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/0d5b653b-f9c5-4adc-b328-68574caf9c9b","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/0d5b653b-f9c5-4adc-b328-68574caf9c9b/application","descriptionHtml":"JOB SUMMARY
The Senior Clinical Trial Manager, Clinical Operations, serves as the operational lead for assigned early-phase oncology studies, providing end-to-end trial leadership from start-up through close-out. In close partnership with Clinical Development, Regulatory, Biometrics, and external CROs, this role drives high-quality, inspection-ready trial execution within a collaborative, growth-stage biotech environment. The Senior CTM is accountable for vendor oversight, risk management, timeline and budget performance, and cross-functional alignment to ensure studies are delivered efficiently and in compliance with global regulatory requirements, ICH-GCP, and company SOPs. This position reports to the Director of Clinical Operations and can be remote or onsite in San Diego.
KEY RESPONSIBILITIES
Provide end-to-end operational leadership for complex clinical trials from start-up through close-out, ensuring delivery on time, within budget, and in compliance with global regulations and company SOPs
Lead cross-functional study teams and drive alignment across Clinical Development, Regulatory, Biometrics, and external partners
Develop and execute enrollment, site management, and monitoring strategies to ensure high-quality trial conduct and performance
Oversee CRO and vendor performance, including KPI management, monitoring quality oversight, document review and approval, and vendor selection support
Partner with Data Management and Medical to conduct ongoing data review and ensure timely query resolution
Develop and manage key study documents and operational tools, including protocols, informed consent forms, project plans, budgets, and study materials.
Lead study-related training for investigators, site personnel, and internal teams.
Proactively identify, assess, and escalate operational risks with mitigation strategies and clear recommendations.
Mentor and support junior clinical operations staff, including potential dotted-line management responsibilities.
Travel up to 10% as required to support study oversight and site engagement
QUALIFICATIONS
Bachelor’s degree in life sciences or related field with 7+ years of progressive clinical trial management experience in biotech, pharmaceutical, and/or CRO environments
Demonstrated expertise managing clinical trials from start-up through close-out, with experience overseeing global, multi-site studies and CRO partners
Experience in oncology clinical trials required; solid tumor and early-phase (Phase I/Ib or II) experience preferred
In-depth knowledge of ICH-GCP, FDA/EMA regulations, and global regulatory requirements, with a strong focus on quality and inspection readiness
Proficiency with clinical trial systems, including CTMS, eTMF platforms, IRT systems, EDC systems, and safety databases
Ability to thrive in a collaborative, fast-paced, growth-stage biotech environment with evolving priorities and high accountability
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nThe Senior Clinical Trial Manager, Clinical Operations, serves as the operational lead for assigned early-phase oncology studies, providing end-to-end trial leadership from start-up through close-out. In close partnership with Clinical Development, Regulatory, Biometrics, and external CROs, this role drives high-quality, inspection-ready trial execution within a collaborative, growth-stage biotech environment. The Senior CTM is accountable for vendor oversight, risk management, timeline and budget performance, and cross-functional alignment to ensure studies are delivered efficiently and in compliance with global regulatory requirements, ICH-GCP, and company SOPs. This position reports to the Director of Clinical Operations and can be remote or onsite in San Diego.\n\n\n\nKEY RESPONSIBILITIES\n\n - Provide end-to-end operational leadership for complex clinical trials from start-up through close-out, ensuring delivery on time, within budget, and in compliance with global regulations and company SOPs\n\n - Lead cross-functional study teams and drive alignment across Clinical Development, Regulatory, Biometrics, and external partners\n\n - Develop and execute enrollment, site management, and monitoring strategies to ensure high-quality trial conduct and performance\n\n - Oversee CRO and vendor performance, including KPI management, monitoring quality oversight, document review and approval, and vendor selection support\n\n - Partner with Data Management and Medical to conduct ongoing data review and ensure timely query resolution\n\n - Develop and manage key study documents and operational tools, including protocols, informed consent forms, project plans, budgets, and study materials.\n\n - Lead study-related training for investigators, site personnel, and internal teams.\n\n - Proactively identify, assess, and escalate operational risks with mitigation strategies and clear recommendations.\n\n - Mentor and support junior clinical operations staff, including potential dotted-line management responsibilities.\n\n - Travel up to 10% as required to support study oversight and site engagement\n\n\n\nQUALIFICATIONS\n\n - Bachelor’s degree in life sciences or related field with 7+ years of progressive clinical trial management experience in biotech, pharmaceutical, and/or CRO environments\n\n - Demonstrated expertise managing clinical trials from start-up through close-out, with experience overseeing global, multi-site studies and CRO partners\n\n - Experience in oncology clinical trials required; solid tumor and early-phase (Phase I/Ib or II) experience preferred\n\n - In-depth knowledge of ICH-GCP, FDA/EMA regulations, and global regulatory requirements, with a strong focus on quality and inspection readiness\n\n - Proficiency with clinical trial systems, including CTMS, eTMF platforms, IRT systems, EDC systems, and safety databases\n\n - Ability to thrive in a collaborative, fast-paced, growth-stage biotech environment with evolving priorities and high accountability\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.\n\n\n\n","compensation":{"compensationTierSummary":"$152K – $190K","scrapeableCompensationSalarySummary":"$152K - $190K","compensationTiers":[{"id":"f5e4ee15-7c6f-40ef-beb7-2358575ff7e2","tierSummary":"$152K – $190K","title":null,"additionalInformation":null,"components":[{"id":"851ceddd-68e0-453c-8872-efb593c63ccf","summary":"$152K – $190K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":152000,"maxValue":190000}]}],"summaryComponents":[{"compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":152000,"maxValue":190000}]}},{"id":"9ddc2691-8f3d-491e-ab10-3a96fe32600a","title":" Research Scientist II/Senior, Discovery Machine Learning","department":"Science","team":"Discovery Machine Learning","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-06-15T23:49:23.840+00:00","isListed":true,"isRemote":null,"workplaceType":null,"address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/9ddc2691-8f3d-491e-ab10-3a96fe32600a","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/9ddc2691-8f3d-491e-ab10-3a96fe32600a/application","descriptionHtml":"JOB SUMMARY
We are seeking skilled scientists to join our Discovery Machine Learning group at Iambic Therapeutics. In this role, you will be a key player in applying advanced ML techniques to support our drug discovery efforts and will be part of drug discovery teams pursuing important therapeutics across multiple indications. The work will include focus on our flagship machine learning models, including Enchant, our multimodal transformer model for predicting drug-target interactions and molecular properties. This role is based at our San Diego headquarters.
KEY RESPONSIBILITIES
Train, fine-tune, and evaluate machine learning models, assessing how they can best be leveraged in a drug-discovery setting and optimizing their performance
Partner with computational chemists, medicinal chemists and biologists to leverage ML insights for decision-making in high-throughput design-make-test-analyze cycles
Generate value, internally and for partners, from our machine learning models, and collaborate with other discovery teams to shape their use
Communicate results with internal drug discovery teams and machine learning scientists and externally with partners
Support the evolution of our machine learning models by gathering analytical feedback and delivering domain-driven guidance to the machine learning team
QUALIFICATIONS
Required:
PhD or equivalent degree in chemistry or another physical science with 3+ years of experience or commensurate degree and job experience. More junior candidates are welcome to apply, title will reflect experience.
Familiarity with using statistical analysis techniques to evaluate, troubleshoot, and adapt models in scientific contexts
Excellent written and verbal communication skills; must be able to articulate complex scientific concepts, technical challenges, and results clearly and concisely to diverse audiences.
Skills: Python programming, statistics, drug discovery
Strongly preferred:
PhD or equivalent degree in computational chemistry or machine learning in chemistry
3+ years of experience working in a drug discovery project
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking skilled scientists to join our Discovery Machine Learning group at Iambic Therapeutics. In this role, you will be a key player in applying advanced ML techniques to support our drug discovery efforts and will be part of drug discovery teams pursuing important therapeutics across multiple indications. The work will include focus on our flagship machine learning models, including Enchant, our multimodal transformer model for predicting drug-target interactions and molecular properties. This role is based at our San Diego headquarters.\n\n\n\nKEY RESPONSIBILITIES\n\n - Train, fine-tune, and evaluate machine learning models, assessing how they can best be leveraged in a drug-discovery setting and optimizing their performance\n\n - Partner with computational chemists, medicinal chemists and biologists to leverage ML insights for decision-making in high-throughput design-make-test-analyze cycles\n\n - Generate value, internally and for partners, from our machine learning models, and collaborate with other discovery teams to shape their use\n\n - Communicate results with internal drug discovery teams and machine learning scientists and externally with partners\n\n - Support the evolution of our machine learning models by gathering analytical feedback and delivering domain-driven guidance to the machine learning team\n\n\n\nQUALIFICATIONS\n\nRequired:\n\n - PhD or equivalent degree in chemistry or another physical science with 3+ years of experience or commensurate degree and job experience. More junior candidates are welcome to apply, title will reflect experience.\n\n - Familiarity with using statistical analysis techniques to evaluate, troubleshoot, and adapt models in scientific contexts\n\n - Excellent written and verbal communication skills; must be able to articulate complex scientific concepts, technical challenges, and results clearly and concisely to diverse audiences.\n\n - Skills: Python programming, statistics, drug discovery\n\nStrongly preferred:\n\n - PhD or equivalent degree in computational chemistry or machine learning in chemistry\n\n - 3+ years of experience working in a drug discovery project\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$146.4K – $203.5K • Multiple Ranges","scrapeableCompensationSalarySummary":"$146.4K - $203.5K","compensationTiers":[{"id":"6487c9f4-53cf-43ea-95cc-70673c94ba1a","tierSummary":"$146.4K – $183K","title":"Research Scientist II","additionalInformation":null,"components":[{"id":"d11b9be5-9f33-4424-947d-f6a917fc0db1","summary":"$146.4K – $183K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":146400,"maxValue":183000}]},{"id":"8460e394-4980-418a-85df-47c2fcf23a3a","tierSummary":"$162.8K – $203.5K","title":"Senior Scientist","additionalInformation":null,"components":[{"id":"43394760-bee7-4ca3-bcbe-ab6c2296f2cb","summary":"$162.8K – $203.5K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":162800,"maxValue":203500}]}],"summaryComponents":[{"minValue":146400,"maxValue":203500,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"d2b9fff3-6519-4efd-b8cd-5a7c1b6f0a6f","title":"Principal Medical Writer","department":"Clinical","team":"Regulatory","employmentType":"FullTime","location":"Remote - US","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-09-04T00:21:57.814+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/d2b9fff3-6519-4efd-b8cd-5a7c1b6f0a6f","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/d2b9fff3-6519-4efd-b8cd-5a7c1b6f0a6f/application","descriptionHtml":"JOB SUMMARY
Iambic Therapeutics is seeking an experienced Principal Medical Writer to independently author and oversee development of high-quality submission-ready documents to support clinical-stage programs and IND submissions.
Reporting to the Head of Medical Writing, this role will partner with cross-functional stakeholders to advance Iambic’s mission of delivering highly differentiated, patient-optimized therapeutics to address urgent unmet medical needs. The ideal candidate will have strong scientific judgment, regulatory writing expertise, and the ability to thrive in a fast-moving, evolving organization.
KEY RESPONSIBILITIES
Responsible for planning, authoring, and delivery of submission-ready documents (protocols, IBs, DSURs, CSRs, INDs, Health Authority responses, and briefing documents etc.)
Independently lead cross-departmental document development by collaborating with the Clinical, Nonclinical, Medical, Biostatistics, CMC, and Regulatory teams
Represent medical writing on internal cross functional study teams and ad hoc working groups
Support development of abstracts, posters, and presentations for scientific conferences
Help establish and refine medical writing processes, templates, and standards to ensure consistency, quality, and accuracy across all deliverables. Implement and manage efficient document workflows and timelines
Participate in the evaluation and integration of AI-enabled tools to improve writing quality and efficiency
QUALIFICATIONS
Bachelor’s degree in a life science (or health-related field) required; advanced degree (Masters/PhD/PharmD) preferred with a minimum 10 years of relevant medical writing experience
Demonstrated experience with IND submissions and documents to support clinical-stage programs
Detail-oriented with excellent scientific writing, communication, and organizational skills
Highly skilled in Microsoft Office suite, particularly MS Word. Experience with electronic document and reference management systems preferred, with a demonstrated aptitude and interest in learning and adopting new technologies, including AI-enabled tools
Strong understanding of FDA/EMA regulations and ICH guidelines
Comfortable working and collaborating in a fast-paced environment
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nIambic Therapeutics is seeking an experienced Principal Medical Writer to independently author and oversee development of high-quality submission-ready documents to support clinical-stage programs and IND submissions.\n\nReporting to the Head of Medical Writing, this role will partner with cross-functional stakeholders to advance Iambic’s mission of delivering highly differentiated, patient-optimized therapeutics to address urgent unmet medical needs. The ideal candidate will have strong scientific judgment, regulatory writing expertise, and the ability to thrive in a fast-moving, evolving organization.\n\n\n\nKEY RESPONSIBILITIES\n\n - Responsible for planning, authoring, and delivery of submission-ready documents (protocols, IBs, DSURs, CSRs, INDs, Health Authority responses, and briefing documents etc.)\n\n - Independently lead cross-departmental document development by collaborating with the Clinical, Nonclinical, Medical, Biostatistics, CMC, and Regulatory teams\n\n - Represent medical writing on internal cross functional study teams and ad hoc working groups\n\n - Support development of abstracts, posters, and presentations for scientific conferences\n\n - Help establish and refine medical writing processes, templates, and standards to ensure consistency, quality, and accuracy across all deliverables. Implement and manage efficient document workflows and timelines\n\n - Participate in the evaluation and integration of AI-enabled tools to improve writing quality and efficiency\n\nQUALIFICATIONS\n\n - Bachelor’s degree in a life science (or health-related field) required; advanced degree (Masters/PhD/PharmD) preferred with a minimum 10 years of relevant medical writing experience\n\n - Demonstrated experience with IND submissions and documents to support clinical-stage programs\n\n - Detail-oriented with excellent scientific writing, communication, and organizational skills\n\n - Highly skilled in Microsoft Office suite, particularly MS Word. Experience with electronic document and reference management systems preferred, with a demonstrated aptitude and interest in learning and adopting new technologies, including AI-enabled tools\n\n - Strong understanding of FDA/EMA regulations and ICH guidelines\n\n - Comfortable working and collaborating in a fast-paced environment\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$152K – $190K","scrapeableCompensationSalarySummary":"$152K - $190K","compensationTiers":[{"id":"2a5e155b-4817-49eb-aad3-4b93551fd2de","tierSummary":"$152K – $190K","title":null,"additionalInformation":null,"components":[{"id":"2e46ac5a-e320-408e-a351-d30a161efaea","summary":"$152K – $190K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":152000,"maxValue":190000}]}],"summaryComponents":[{"compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":152000,"maxValue":190000}]}},{"id":"e418c9bf-4fe6-4484-92ad-e9a320557815","title":"Machine Learning Scientist – Clinical Prediction","department":"Technology","team":"Machine Learning","employmentType":"FullTime","location":"Boston Office","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[{"location":"Remote - US","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}}}],"publishedAt":"2026-08-31T16:48:49.525+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"MA","addressCountry":"US","addressLocality":"Boston"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/e418c9bf-4fe6-4484-92ad-e9a320557815","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/e418c9bf-4fe6-4484-92ad-e9a320557815/application","descriptionHtml":"JOB SUMMARY
We are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. In this role, you will design and implement clinical fine-tuning of Enchant, our multimodal transformer model trained on a wide variety of biomedical data, pushing the boundaries of what large-scale foundation models can achieve in drug discovery.
This role spans data sourcing through to production deployment. You will identify, curate, and evaluate datasets that support prediction of relevant clinical endpoints (patient- and trial-level outcome modeling, safety/toxicity prediction, and PK/PD response modeling) and fine-tune Enchant to deliver critical clinical insights. This includes developing rigorous, leakage-resistant experimental frameworks, optimizing training, orchestrating runs at scale, and working with colleagues across ML and clinical functions to put these models into the hands of scientists making real therapeutic decisions.
KEY RESPONSIBILITIES
Fine-tune large-scale multimodal transformer models for clinical and biomedical applications
Identify, characterize, and utilize datasets that can deliver insights into pharmacokinetics (PK), pharmacodynamics (PD), toxicity, clinical adverse events, and clinical trial outcomes
Develop and apply rigorous experimental approaches that account for multiple sources of potential leakage (split, metadata, trial-family, temporal, ontological, arm-comparator, etc.)
Design and maintain benchmarking and evaluation frameworks that track model quality across models and tasks
Build models with appropriate calibration, uncertainty quantification, and clinically meaningful evaluation metrics.
Collaborate with ML and software engineering colleagues to deploy and operationalize models
Partner with clinical scientists and pharmacologists to ensure model development is grounded in drug discovery and development needs
Communicate results to internal teams, external partners, and at conferences
Generate high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity
REQUIRED QUALIFICATIONS
MS in chemistry, bio/chemical engineering, or a computational STEM field with 3+ years of relevant industry or research experience, or PhD or equivalent industry experience demonstrating comparable depth
Strong Python experience, including implementing and fine-tuning deep learning models
Demonstrated experience in clinical science or working with clinical datasets
Excellent Data Science skills (problem framing, data sourcing, extraction, cleaning, visualization, EDA, modeling, tuning, storytelling, etc.)
Enough independence to own a workstream from data ingestion through evaluation
Strong engineering habits: reproducible experimentation, appropriate control strategy, clean code, testing
Comfort working with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking such as Weights & Biases)
PREFERRED QUALIFICATIONS
Experience building and deploying clinically relevant prediction models
Familiarity with ClinicalTrials.gov/AACT data
Experience with MedDRA, pharmacovigilance, or adverse event data
Direct exposure to multi-task learning
Hands-on experience with agentic data extraction
HPC or large-scale computing experience
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. In this role, you will design and implement clinical fine-tuning of Enchant, our multimodal transformer model trained on a wide variety of biomedical data, pushing the boundaries of what large-scale foundation models can achieve in drug discovery.\n\nThis role spans data sourcing through to production deployment. You will identify, curate, and evaluate datasets that support prediction of relevant clinical endpoints (patient- and trial-level outcome modeling, safety/toxicity prediction, and PK/PD response modeling) and fine-tune Enchant to deliver critical clinical insights. This includes developing rigorous, leakage-resistant experimental frameworks, optimizing training, orchestrating runs at scale, and working with colleagues across ML and clinical functions to put these models into the hands of scientists making real therapeutic decisions.\n\n\n\nKEY RESPONSIBILITIES\n\n - Fine-tune large-scale multimodal transformer models for clinical and biomedical applications\n\n - Identify, characterize, and utilize datasets that can deliver insights into pharmacokinetics (PK), pharmacodynamics (PD), toxicity, clinical adverse events, and clinical trial outcomes\n\n - Develop and apply rigorous experimental approaches that account for multiple sources of potential leakage (split, metadata, trial-family, temporal, ontological, arm-comparator, etc.)\n\n - Design and maintain benchmarking and evaluation frameworks that track model quality across models and tasks\n\n - Build models with appropriate calibration, uncertainty quantification, and clinically meaningful evaluation metrics.\n\n - Collaborate with ML and software engineering colleagues to deploy and operationalize models\n\n - Partner with clinical scientists and pharmacologists to ensure model development is grounded in drug discovery and development needs\n\n - Communicate results to internal teams, external partners, and at conferences\n\n - Generate high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity\n\n\n\nREQUIRED QUALIFICATIONS\n\n - MS in chemistry, bio/chemical engineering, or a computational STEM field with 3+ years of relevant industry or research experience, or PhD or equivalent industry experience demonstrating comparable depth\n\n - Strong Python experience, including implementing and fine-tuning deep learning models\n\n - Demonstrated experience in clinical science or working with clinical datasets\n\n - Excellent Data Science skills (problem framing, data sourcing, extraction, cleaning, visualization, EDA, modeling, tuning, storytelling, etc.)\n\n - Enough independence to own a workstream from data ingestion through evaluation\n\n - Strong engineering habits: reproducible experimentation, appropriate control strategy, clean code, testing\n\n - Comfort working with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking such as Weights & Biases)\n\n\n\nPREFERRED QUALIFICATIONS\n\n - Experience building and deploying clinically relevant prediction models\n\n - Familiarity with ClinicalTrials.gov/AACT http://ClinicalTrials.gov/AACT data\n\n - Experience with MedDRA, pharmacovigilance, or adverse event data\n\n - Direct exposure to multi-task learning\n\n - Hands-on experience with agentic data extraction\n\n - HPC or large-scale computing experience\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$148K – $186K","scrapeableCompensationSalarySummary":"$148K - $186K","compensationTiers":[{"id":"40c419c7-5a3b-48a1-832c-11baca5bae8c","tierSummary":"$148K – $186K","title":null,"additionalInformation":null,"components":[{"id":"4cd31bc0-4461-4cec-be7d-466b71996d61","summary":"$148K – $186K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":148000,"maxValue":186000}]}],"summaryComponents":[{"compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":148000,"maxValue":186000}]}},{"id":"77e13632-a60f-4cbb-8f7e-73a2f0f8c6df","title":"Sr Manager, FP&A - Discovery R&D","department":"G&A","team":"Finance","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-09-12T00:45:43.387+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/77e13632-a60f-4cbb-8f7e-73a2f0f8c6df","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/77e13632-a60f-4cbb-8f7e-73a2f0f8c6df/application","descriptionHtml":"JOB SUMMARY
We are hiring a Senior Manager – Discovery R&D to join the growing Finance Team at Iambic, an innovative biotech company redefining drug discovery and development by applying industry-leading AI and Machine Learning technology. Reporting to the Head of FP&A, this role will be responsible for partnering with our Discovery R&D groups on a broad range of planning and forecasting activities for Iambic’s internal pipeline and external partnership programs and providing them with detailed analytics and insights to help inform strategic decision-making. This position will be based in our San Diego Headquarters, with exceptions for experienced candidates to work remotely.
RESPONSIBILITIES
Serve as primary finance business partner for all Discovery groups covering both internal pipeline and external partnership programs, including Computational Chemistry, Medicinal Chemistry, Biology, DMPK, Analytical, Toxicology, and HTE & Lab Operations.
Lead the financial planning process (annual planning cycle, mid-year reforecast and quarterly budget-to-actual meetings) for all Discovery groups.
Develop and maintain robust financial models and budgets to track all spending by group, program, and project, and detailed headcount plans.
Provide timely and actionable financial insights to senior leadership in support of strategic decision-making.
Assist in long-range planning efforts as well as scenario planning initiatives for our internal pipeline and external partnership programs.
Build comprehensive program budgets to support Business Development scaling efforts and ongoing negotiations.
Collaborate with the Accounting team on month-end close activities, including preclinical and other accruals.
Support the development of scalable, gold-standard FP&A tools, systems and processes as the company grows.
Work effectively as a team contributor on all assignments, as well as independently, while understanding the necessity for communicating and coordinating work efforts with colleagues across the organization.
Perform ad hoc analysis and special projects, as assigned.
QUALIFICATIONS
Bachelor’s degree in Accounting, Finance, Economics, or a related discipline preferred. Equivalent work experience will be considered; MBA or CPA a plus.
8 - 12 years of professional FP&A experience within biotech, pharma or life sciences. Prior experience in investment banking, public accounting, or management consulting is a plus.
Strong understanding of R&D life cycles, preclinical drug discovery and development processes, and associated cost drivers.
Advanced Excel and financial modeling skills; prior experience with enterprise resource planning (ERP) systems (e.g. NetSuite) and financial planning tools (e.g. Adaptive Planning, Anaplan, or similar) is preferred.
Strong communication and presentation skills required, with the ability to partner effectively across scientific and business teams.
Ability to prioritize, coordinate and handle multiple projects to meet deadlines.
Self-motivated and strong desire to build new processes and tools to support a growth-oriented organization.
Strong analytical mindset, attention to detail, and ability to thrive in a fast-paced, dynamic environment are required.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are hiring a Senior Manager – Discovery R&D to join the growing Finance Team at Iambic, an innovative biotech company redefining drug discovery and development by applying industry-leading AI and Machine Learning technology. Reporting to the Head of FP&A, this role will be responsible for partnering with our Discovery R&D groups on a broad range of planning and forecasting activities for Iambic’s internal pipeline and external partnership programs and providing them with detailed analytics and insights to help inform strategic decision-making. This position will be based in our San Diego Headquarters, with exceptions for experienced candidates to work remotely.\n\n\n\nRESPONSIBILITIES\n\n - Serve as primary finance business partner for all Discovery groups covering both internal pipeline and external partnership programs, including Computational Chemistry, Medicinal Chemistry, Biology, DMPK, Analytical, Toxicology, and HTE & Lab Operations.\n\n - Lead the financial planning process (annual planning cycle, mid-year reforecast and quarterly budget-to-actual meetings) for all Discovery groups.\n\n - Develop and maintain robust financial models and budgets to track all spending by group, program, and project, and detailed headcount plans.\n\n - Provide timely and actionable financial insights to senior leadership in support of strategic decision-making.\n\n - Assist in long-range planning efforts as well as scenario planning initiatives for our internal pipeline and external partnership programs.\n\n - Build comprehensive program budgets to support Business Development scaling efforts and ongoing negotiations.\n\n - Collaborate with the Accounting team on month-end close activities, including preclinical and other accruals.\n\n - Support the development of scalable, gold-standard FP&A tools, systems and processes as the company grows.\n\n - Work effectively as a team contributor on all assignments, as well as independently, while understanding the necessity for communicating and coordinating work efforts with colleagues across the organization.\n\n - Perform ad hoc analysis and special projects, as assigned.\n\n\n\nQUALIFICATIONS\n\n - Bachelor’s degree in Accounting, Finance, Economics, or a related discipline preferred. Equivalent work experience will be considered; MBA or CPA a plus.\n\n - 8 - 12 years of professional FP&A experience within biotech, pharma or life sciences. Prior experience in investment banking, public accounting, or management consulting is a plus.\n\n - Strong understanding of R&D life cycles, preclinical drug discovery and development processes, and associated cost drivers.\n\n - Advanced Excel and financial modeling skills; prior experience with enterprise resource planning (ERP) systems (e.g. NetSuite) and financial planning tools (e.g. Adaptive Planning, Anaplan, or similar) is preferred.\n\n - Strong communication and presentation skills required, with the ability to partner effectively across scientific and business teams.\n\n - Ability to prioritize, coordinate and handle multiple projects to meet deadlines.\n\n - Self-motivated and strong desire to build new processes and tools to support a growth-oriented organization.\n\n - Strong analytical mindset, attention to detail, and ability to thrive in a fast-paced, dynamic environment are required.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$144K – $180K","scrapeableCompensationSalarySummary":"$144K - $180K","compensationTiers":[{"id":"2f1e2a5b-80f8-439e-8174-6636bb6ff0c5","tierSummary":"$144K – $180K","title":null,"additionalInformation":null,"components":[{"id":"7a4d74e4-7e6e-4f9e-a3fa-7c672807413f","summary":"$144K – $180K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":144000,"maxValue":180000}]}],"summaryComponents":[{"compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":144000,"maxValue":180000}]}},{"id":"7d806fa5-430d-49f2-b980-7c1e66e21fd6","title":"Director, Alliance Management - Drug Discovery Collaborations","department":"Science","team":"Biology","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-07-22T20:44:16.596+00:00","isListed":true,"isRemote":null,"workplaceType":null,"address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/7d806fa5-430d-49f2-b980-7c1e66e21fd6","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/7d806fa5-430d-49f2-b980-7c1e66e21fd6/application","descriptionHtml":"JOB SUMMARY
We are seeking an experienced Director of Alliance Management to support strategic drug discovery collaborations. In this role, you will serve as the primary relationship lead for external partnerships, drive operational execution across collaborations, and work closely with scientific and functional leaders to ensure partnered programs advance scientific, operational, and strategic objectives.
You will coordinate cross-functional teams across medicinal chemistry, biology, DMPK, pharmacology, toxicology, CMC, legal, business development, and project management while serving as a trusted partner to pharmaceutical and biotechnology collaborators. Success in this role requires exceptional program leadership, relationship management, and a strong understanding of the drug discovery process, with the ability to coordinate complex cross-functional programs, anticipate risks, and keep collaborations aligned from early discovery through preclinical development.
We prefer candidates who can work onsite at our San Diego headquarters, but we are open to hybrid working models and remote U.S.-based applicants.
KEY RESPONSIBILITIES
Serve as the primary alliance manager for drug discovery collaborations and strategic external partnerships.
Build and maintain trusted relationships with pharmaceutical and biotechnology partners across scientific, operational, and executive levels.
Lead collaboration governance, including Joint Steering Committees (JSCs), scientific working groups, executive reviews, agendas, action tracking, and decision documentation.
Partner with Biology, Medicinal Chemistry, DMPK, Pharmacology, Toxicology, CMC, Legal, Business Development, and project teams to ensure alignment on collaboration objectives, milestones, and deliverables.
Develop and maintain integrated collaboration plans, including timelines, governance milestones, partner commitments, contractual obligations, budgets, and partnership metrics.
Coordinate cross-functional execution across multiple partnered programs by proactively identifying risks, tracking dependencies, facilitating issue resolution, and ensuring operational excellence.
Support execution across the drug discovery lifecycle by coordinating milestones spanning target identification, hit discovery, lead optimization, DMPK/ADME, pharmacology, toxicology, compound supply, and development candidate nomination.
Maintain visibility into integrated discovery timelines, including design-make-test-analyze (DMTA) cycles, assay execution, data delivery, partner review cycles, and governance decision points.
Partner with Legal and Business Development to support collaboration agreements, governance structures, data sharing, publications, and strategic partnership activities.
Prepare executive updates, partnership reports, and presentations while contributing to evaluation and launch of new strategic collaborations.
Help establish and continuously improve alliance management processes, governance standards, and best practices.
QUALIFICATIONS
Required
Bachelor's degree in a scientific discipline, engineering, business, or related field; advanced degree (M.S. or Ph.D.) preferred.
12+ years in alliance management, scientific program management, project management, scientific operations, or related functions within biotechnology or pharmaceuticals.
Experience managing complex scientific collaborations and strategic partnerships.
Strong understanding of small molecule drug discovery from target identification through preclinical development.
Ability to influence multidisciplinary teams without direct authority.
Excellent organizational, communication, and stakeholder management skills.
Preferred
Experience supporting discovery through IND-enabling activities, including DMTA workflows, DMPK/ADME, pharmacology, toxicology, and CMC.
Experience working with pharmaceutical, biotechnology, academic, or CRO partners.
Familiarity with collaboration agreements, governance structures, and cross-company research programs.
Alliance Management (ASAP), PMP, or similar certification.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking an experienced Director of Alliance Management to support strategic drug discovery collaborations. In this role, you will serve as the primary relationship lead for external partnerships, drive operational execution across collaborations, and work closely with scientific and functional leaders to ensure partnered programs advance scientific, operational, and strategic objectives.\n\nYou will coordinate cross-functional teams across medicinal chemistry, biology, DMPK, pharmacology, toxicology, CMC, legal, business development, and project management while serving as a trusted partner to pharmaceutical and biotechnology collaborators. Success in this role requires exceptional program leadership, relationship management, and a strong understanding of the drug discovery process, with the ability to coordinate complex cross-functional programs, anticipate risks, and keep collaborations aligned from early discovery through preclinical development.\n\nWe prefer candidates who can work onsite at our San Diego headquarters, but we are open to hybrid working models and remote U.S.-based applicants.\n\n\n\nKEY RESPONSIBILITIES\n\n - Serve as the primary alliance manager for drug discovery collaborations and strategic external partnerships.\n\n - Build and maintain trusted relationships with pharmaceutical and biotechnology partners across scientific, operational, and executive levels.\n\n - Lead collaboration governance, including Joint Steering Committees (JSCs), scientific working groups, executive reviews, agendas, action tracking, and decision documentation.\n\n - Partner with Biology, Medicinal Chemistry, DMPK, Pharmacology, Toxicology, CMC, Legal, Business Development, and project teams to ensure alignment on collaboration objectives, milestones, and deliverables.\n\n - Develop and maintain integrated collaboration plans, including timelines, governance milestones, partner commitments, contractual obligations, budgets, and partnership metrics.\n\n - Coordinate cross-functional execution across multiple partnered programs by proactively identifying risks, tracking dependencies, facilitating issue resolution, and ensuring operational excellence.\n\n - Support execution across the drug discovery lifecycle by coordinating milestones spanning target identification, hit discovery, lead optimization, DMPK/ADME, pharmacology, toxicology, compound supply, and development candidate nomination.\n\n - Maintain visibility into integrated discovery timelines, including design-make-test-analyze (DMTA) cycles, assay execution, data delivery, partner review cycles, and governance decision points.\n\n - Partner with Legal and Business Development to support collaboration agreements, governance structures, data sharing, publications, and strategic partnership activities.\n\n - Prepare executive updates, partnership reports, and presentations while contributing to evaluation and launch of new strategic collaborations.\n\n - Help establish and continuously improve alliance management processes, governance standards, and best practices.\n\n\n\nQUALIFICATIONS\n\nRequired\n\n - Bachelor's degree in a scientific discipline, engineering, business, or related field; advanced degree (M.S. or Ph.D.) preferred.\n\n - 12+ years in alliance management, scientific program management, project management, scientific operations, or related functions within biotechnology or pharmaceuticals.\n\n - Experience managing complex scientific collaborations and strategic partnerships.\n\n - Strong understanding of small molecule drug discovery from target identification through preclinical development.\n\n - Ability to influence multidisciplinary teams without direct authority.\n\n - Excellent organizational, communication, and stakeholder management skills.\n\nPreferred\n\n - Experience supporting discovery through IND-enabling activities, including DMTA workflows, DMPK/ADME, pharmacology, toxicology, and CMC.\n\n - Experience working with pharmaceutical, biotechnology, academic, or CRO partners.\n\n - Familiarity with collaboration agreements, governance structures, and cross-company research programs.\n\n - Alliance Management (ASAP), PMP, or similar certification.\n \n \n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$175K – $240K","scrapeableCompensationSalarySummary":"$175K - $240K","compensationTiers":[{"id":"2672be93-4188-4ddd-aef4-eacb2782d7af","tierSummary":"$175K – $240K","title":null,"additionalInformation":null,"components":[{"id":"e4693180-8da1-42f7-a12c-0495583d926e","summary":"$175K – $240K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":175000,"maxValue":240000}]}],"summaryComponents":[{"compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":175000,"maxValue":240000}]}},{"id":"3d06348d-a8a7-4190-883e-07f67965154f","title":"Associate Director/Director, Alliance Management - AI Discovery","department":"Science","team":"Discovery Machine Learning","employmentType":"FullTime","location":"Remote - US","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-07-22T20:56:19.177+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/3d06348d-a8a7-4190-883e-07f67965154f","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/3d06348d-a8a7-4190-883e-07f67965154f/application","descriptionHtml":"JOB SUMMARY
We are seeking an experienced Associate Director or Director of Alliance Management to support AI discovery collaborations. In this role, you will serve as the primary relationship lead for external partnerships, contribute operationally to collaborations, and work closely with other leaders in Iambic to ensure that collaborations advance scientific, operational, and strategic objectives.
You will coordinate cross-functional teams across machine learning, computational chemistry, biology, software engineering, legal, and business development while serving as a trusted partner to pharmaceutical and biotechnology collaborators. Success in this role requires exceptional program leadership and relationship management, together with the ability to translate complex scientific goals into well-executed collaborative projects.
We will prefer candidates who can work onsite at our SD Headquarters, but we are open to hybrid working models and remote US-based applicants.
KEY RESPONSIBILITIES
Serve as the primary alliance manager for AI-enabled drug discovery collaborations and strategic external partnerships.
Build and maintain trusted relationships with pharmaceutical, biotechnology, and technology partners across scientific, operational, and executive levels.
Lead collaboration governance, including Joint Steering Committees (JSCs), scientific working groups, executive reviews, agendas, action tracking, and decision documentation.
Partner with Discovery Machine Learning, Computational Chemistry, Biology, Medicinal Chemistry, Software Engineering, Legal, Business Development, and other cross-functional teams to ensure alignment on collaboration objectives, milestones, and deliverables.
Develop and maintain integrated collaboration plans, including timelines, governance milestones, partner commitments, contractual obligations, budgets, and partnership metrics.
Coordinate cross-functional execution across multiple partnered programs by proactively identifying risks, tracking dependencies, facilitating issue resolution, and ensuring operational excellence.
Translate complex AI, machine learning, computational chemistry, and scientific concepts into clear, actionable updates for external collaborators while ensuring alignment between technical teams and partner objectives.
Develop sufficient technical understanding of Iambic's AI discovery platform and computational workflows to effectively represent collaborative programs, anticipate partner questions, and facilitate productive scientific discussions.
Partner with Legal and Business Development to support collaboration agreements, governance structures, data sharing, publications, and strategic partnership activities.
Prepare executive updates, partnership reports, and presentations while contributing to evaluation and launch of new strategic collaborations.
Help establish and continuously improve alliance management processes, governance standards, and best practices as Iambic's collaboration portfolio grows.
QUALIFICATIONS
Bachelor's degree in a scientific discipline, engineering, business, or related field; advanced degree (M.S. or Ph.D.) preferred
10+ years of experience (Associate Director) or 12+ years (Director) in alliance management, scientific program management, project management, or scientific operations within biotechnology, pharmaceuticals, or AI-driven life sciences.
Demonstrated experience working in small-molecule drug discovery, ideally within an AI-enabled or computational research environment.
Experience managing complex scientific collaborations and strategic partnerships.
Understanding of drug discovery, machine learning, or computational research environments.
Exceptional organizational, communication, and stakeholder management skills.
Proven ability to influence across multidisciplinary teams without direct authority.
Preferred
Experience supporting AI, machine learning, computational biology, computational chemistry, or AI-enabled drug discovery organizations.
Experience working with pharmaceutical, biotechnology, academic, or technology collaborations.
Familiarity with collaboration agreements, governance structures, and cross-company research programs.
Alliance Management (ASAP), PMP, or similar certification.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking an experienced Associate Director or Director of Alliance Management to support AI discovery collaborations. In this role, you will serve as the primary relationship lead for external partnerships, contribute operationally to collaborations, and work closely with other leaders in Iambic to ensure that collaborations advance scientific, operational, and strategic objectives.\n\nYou will coordinate cross-functional teams across machine learning, computational chemistry, biology, software engineering, legal, and business development while serving as a trusted partner to pharmaceutical and biotechnology collaborators. Success in this role requires exceptional program leadership and relationship management, together with the ability to translate complex scientific goals into well-executed collaborative projects.\n\nWe will prefer candidates who can work onsite at our SD Headquarters, but we are open to hybrid working models and remote US-based applicants.\n\n\n\nKEY RESPONSIBILITIES\n\n - Serve as the primary alliance manager for AI-enabled drug discovery collaborations and strategic external partnerships.\n\n - Build and maintain trusted relationships with pharmaceutical, biotechnology, and technology partners across scientific, operational, and executive levels.\n\n - Lead collaboration governance, including Joint Steering Committees (JSCs), scientific working groups, executive reviews, agendas, action tracking, and decision documentation.\n\n - Partner with Discovery Machine Learning, Computational Chemistry, Biology, Medicinal Chemistry, Software Engineering, Legal, Business Development, and other cross-functional teams to ensure alignment on collaboration objectives, milestones, and deliverables.\n\n - Develop and maintain integrated collaboration plans, including timelines, governance milestones, partner commitments, contractual obligations, budgets, and partnership metrics.\n\n - Coordinate cross-functional execution across multiple partnered programs by proactively identifying risks, tracking dependencies, facilitating issue resolution, and ensuring operational excellence.\n\n - Translate complex AI, machine learning, computational chemistry, and scientific concepts into clear, actionable updates for external collaborators while ensuring alignment between technical teams and partner objectives.\n\n - Develop sufficient technical understanding of Iambic's AI discovery platform and computational workflows to effectively represent collaborative programs, anticipate partner questions, and facilitate productive scientific discussions.\n\n - Partner with Legal and Business Development to support collaboration agreements, governance structures, data sharing, publications, and strategic partnership activities.\n\n - Prepare executive updates, partnership reports, and presentations while contributing to evaluation and launch of new strategic collaborations.\n\n - Help establish and continuously improve alliance management processes, governance standards, and best practices as Iambic's collaboration portfolio grows.\n\n\n\nQUALIFICATIONS\n\n - Bachelor's degree in a scientific discipline, engineering, business, or related field; advanced degree (M.S. or Ph.D.) preferred\n\n - 10+ years of experience (Associate Director) or 12+ years (Director) in alliance management, scientific program management, project management, or scientific operations within biotechnology, pharmaceuticals, or AI-driven life sciences.\n\n - Demonstrated experience working in small-molecule drug discovery, ideally within an AI-enabled or computational research environment.\n\n - Experience managing complex scientific collaborations and strategic partnerships.\n\n - Understanding of drug discovery, machine learning, or computational research environments.\n\n - Exceptional organizational, communication, and stakeholder management skills.\n\n - Proven ability to influence across multidisciplinary teams without direct authority.\n\nPreferred\n\n - Experience supporting AI, machine learning, computational biology, computational chemistry, or AI-enabled drug discovery organizations.\n\n - Experience working with pharmaceutical, biotechnology, academic, or technology collaborations.\n\n - Familiarity with collaboration agreements, governance structures, and cross-company research programs.\n\n - Alliance Management (ASAP), PMP, or similar certification.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$155K – $240K • Multiple Ranges","scrapeableCompensationSalarySummary":"$155K - $240K","compensationTiers":[{"id":"1d83ea66-3de7-4986-97a8-fd203450a25e","tierSummary":"$155K – $195K","title":"Associate Director","additionalInformation":null,"components":[{"id":"7a81e552-5dcd-4d50-a64b-9157e2381d7a","summary":"$155K – $195K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":155000,"maxValue":195000}]},{"id":"527e9b35-9b0c-4ea2-abfb-e0e96de78282","tierSummary":"$175K – $240K","title":"Director","additionalInformation":null,"components":[{"id":"ee0db562-204e-4317-81cc-df09d5231e63","summary":"$175K – $240K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":175000,"maxValue":240000}]}],"summaryComponents":[{"minValue":155000,"maxValue":240000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"df3de5b0-b4df-4421-be9b-3ac7bb8f5554","title":"Senior / Executive Medical Director, Clinical Development (Oncology)","department":"Clinical","team":"Clinical Development","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-08-07T23:45:17.013+00:00","isListed":true,"isRemote":null,"workplaceType":null,"address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/df3de5b0-b4df-4421-be9b-3ac7bb8f5554","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/df3de5b0-b4df-4421-be9b-3ac7bb8f5554/application","descriptionHtml":"JOB SUMMARY
We are seeking a Senior or Executive Medical Director to provide medical and clinical development leadership for our early-stage oncology portfolio. This individual will own the clinical strategy and execution for one or more assets from IND-enabling activities through first-in-human and early efficacy studies. You will serve as the clinical and scientific lead on cross-functional program teams, working closely with our discovery, translational, regulatory, and clinical operations groups — and directly alongside our AI/ML platform teams — to translate novel candidates into well-designed clinical programs.
This position will be based in our San Diego Headquarters.
Title and scope will be calibrated to the successful candidate's experience.
KEY RESPONSIBILITIES
Serve as the clinical/medical lead for early-stage oncology programs, owning the clinical development strategy from IND through Phase 1 and early proof-of-concept.
Author and drive the clinical components of IND submissions, including protocols, investigator's brochures, and clinical sections of regulatory documents; support and participate in health authority interactions (e.g., pre-IND, EOP1).
Design first-in-human and early-phase oncology trials, including dose-escalation and dose-optimization strategies, biomarker and translational plans, and eligibility criteria.
Provide ongoing medical monitoring and safety oversight for active trials, including review of emerging safety data, dose decisions, and management of study conduct in partnership with Clinical Operations and Pharmacovigilance.
Partner with translational science and the AI/ML platform teams to define patient selection strategies, pharmacodynamic endpoints, and data-driven development hypotheses.
Engage key opinion leaders, investigators, and study sites; represent programs to internal governance, partners, and, as appropriate, external stakeholders.
Collaborate cross-functionally with Regulatory Affairs, CMC, Clinical Operations, Biostatistics, and Program Management to keep programs on strategy and on timeline.
Contribute to portfolio-level decisions, candidate selection input, and business development / due diligence as needed.
QUALIFICATIONS
M.D. or D.O. (or international equivalent); board eligibility/certification in hematology/oncology or medical oncology strongly preferred; exceptional candidates with PharmD and relevant oncology and clinical experience will be considered
Meaningful drug-development experience in biotech or pharma. We anticipate roughly 5+ years for a Senior Medical Director and 8–10+ years for an Executive Medical Director; strong candidates across this range are encouraged to apply.
Direct, hands-on experience authoring and executing IND submissions.
Direct experience designing and running Phase 1 / early-phase oncology clinical trials.
Demonstrated experience with oncology assets and a strong understanding of the oncology therapeutic and drug-development landscape.
Working knowledge of GCP, ICH guidelines, and the global regulatory environment for oncology development.
PREFERRED QUALIFICATIONS
Experience with small-molecule oncology programs and targeted therapies.
Experience taking a program from candidate nomination or IND through clinical proof-of-concept.
Comfort working in a fast-paced, data-rich, technology-forward environment and collaborating with computational and platform teams.
Prior experience presenting to health authorities and/or supporting BD due diligence
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking a Senior or Executive Medical Director to provide medical and clinical development leadership for our early-stage oncology portfolio. This individual will own the clinical strategy and execution for one or more assets from IND-enabling activities through first-in-human and early efficacy studies. You will serve as the clinical and scientific lead on cross-functional program teams, working closely with our discovery, translational, regulatory, and clinical operations groups — and directly alongside our AI/ML platform teams — to translate novel candidates into well-designed clinical programs.\n\nThis position will be based in our San Diego Headquarters.\n\nTitle and scope will be calibrated to the successful candidate's experience.\n\nKEY RESPONSIBILITIES\n\n - Serve as the clinical/medical lead for early-stage oncology programs, owning the clinical development strategy from IND through Phase 1 and early proof-of-concept.\n\n - Author and drive the clinical components of IND submissions, including protocols, investigator's brochures, and clinical sections of regulatory documents; support and participate in health authority interactions (e.g., pre-IND, EOP1).\n\n - Design first-in-human and early-phase oncology trials, including dose-escalation and dose-optimization strategies, biomarker and translational plans, and eligibility criteria.\n\n - Provide ongoing medical monitoring and safety oversight for active trials, including review of emerging safety data, dose decisions, and management of study conduct in partnership with Clinical Operations and Pharmacovigilance.\n\n - Partner with translational science and the AI/ML platform teams to define patient selection strategies, pharmacodynamic endpoints, and data-driven development hypotheses.\n\n - Engage key opinion leaders, investigators, and study sites; represent programs to internal governance, partners, and, as appropriate, external stakeholders.\n\n - Collaborate cross-functionally with Regulatory Affairs, CMC, Clinical Operations, Biostatistics, and Program Management to keep programs on strategy and on timeline.\n\n - Contribute to portfolio-level decisions, candidate selection input, and business development / due diligence as needed.\n \n \n\nQUALIFICATIONS\n\n - M.D. or D.O. (or international equivalent); board eligibility/certification in hematology/oncology or medical oncology strongly preferred; exceptional candidates with PharmD and relevant oncology and clinical experience will be considered\n\n - Meaningful drug-development experience in biotech or pharma. We anticipate roughly 5+ years for a Senior Medical Director and 8–10+ years for an Executive Medical Director; strong candidates across this range are encouraged to apply.\n\n - Direct, hands-on experience authoring and executing IND submissions.\n\n - Direct experience designing and running Phase 1 / early-phase oncology clinical trials.\n\n - Demonstrated experience with oncology assets and a strong understanding of the oncology therapeutic and drug-development landscape.\n\n - Working knowledge of GCP, ICH guidelines, and the global regulatory environment for oncology development.\n\nPREFERRED QUALIFICATIONS\n\n - Experience with small-molecule oncology programs and targeted therapies.\n\n - Experience taking a program from candidate nomination or IND through clinical proof-of-concept.\n\n - Comfort working in a fast-paced, data-rich, technology-forward environment and collaborating with computational and platform teams.\n\n - Prior experience presenting to health authorities and/or supporting BD due diligence\n \n \n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\n\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\n\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$270K – $367K • Multiple Ranges","scrapeableCompensationSalarySummary":"$270K - $367K","compensationTiers":[{"id":"b4b5d8ea-b9ef-493d-856c-8ce2b1f26223","tierSummary":"$270K – $338K","title":"Senior Director","additionalInformation":null,"components":[{"id":"23d34bb1-688b-4db4-96af-5f4988edfe72","summary":"$270K – $338K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":270000,"maxValue":338000}]},{"id":"b3b95c4a-1f94-4985-b4a3-75d246303b8a","tierSummary":"$293K – $367K","title":"Executive Director ","additionalInformation":null,"components":[{"id":"ac00f8f3-e1b8-4595-9355-10ec7b3198d8","summary":"$293K – $367K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":293000,"maxValue":367000}]}],"summaryComponents":[{"minValue":270000,"maxValue":367000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"6236b729-9139-4971-8a31-3f5a9add1ed4","title":"Research Scientist II/Senior, Computational Chemistry","department":"Science","team":"Computational Chemistry","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[{"location":"Remote - US","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}}}],"publishedAt":"2026-08-15T00:36:18.948+00:00","isListed":true,"isRemote":null,"workplaceType":null,"address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/6236b729-9139-4971-8a31-3f5a9add1ed4","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/6236b729-9139-4971-8a31-3f5a9add1ed4/application","descriptionHtml":"JOB SUMMARY
We are seeking a skilled and highly motivated Computational Chemist to join our Computational Sciences group at Iambic Therapeutics. You will be a key player in the application of advanced ligand and structure-based techniques to drive our drug discovery efforts. You will play an active role in the research teams pursuing important therapeutics across multiple indications. You will work in a cross-functional team, collaborating closely with machine learning scientists, medicinal chemists and biologists to apply cutting edge SBDD methods across hit identification, lead optimization, and candidate selection phases. This is a hands-on role, requiring technical expertise in computational chemistry, experience with or strong interest in applying modern co-folding approaches, familiarity with the drug discovery process and a proactive drug-hunter mindset. This role will involve engagement in external partnerships.
This position will be based in our San Diego Headquarters, with exceptions for outstanding candidates to work remotely.
KEY RESPONSIBILITIES
Apply a range of ligand and structure-based approaches across hit identification, hit to lead and lead optimization phases (e.g. cheminformatics, pharmacophore modeling, docking and shape-based based virtual screening, de novo molecular design, MD simulation)
Guide design cycles through the identification of structure-activity relationships and the integration of computational predictions with bioactivity data
Partner with medicinal chemists to design, evaluate and prioritize virtual libraries, and propose actionable molecular designs
Partner with ML scientists to integrate SBDD methods with our proprietary transformer-based property prediction technology (Enchant)
Leverage and evolve our proprietary protein-ligand co-folding technology (NeuralPLexer) to yield novel and actionable structural hypotheses
Translate scientific questions into computational workflows and deliver actionable results
Present results to internal project teams and external partners, explaining methods, implications and recommendations
Develop, validate, and maintain computational workflows and tools
QUALIFICATIONS
Required:
PhD or equivalent degree in computational chemistry (or related field) with 2+ years of relevant experience in drug discovery
Experience supporting active small molecule drug discovery programs
Experience with ligand and structure based design tools
Proficiency in Python for scientific computing, data analysis, and computational workflow development
Excellent written and verbal communication skills; must be able to articulate complex scientific concepts, technical challenges, and results clearly and concisely to diverse audiences.
Strongly preferred:
Industry experience supporting active drug discovery programs
Experience with molecular modeling platforms such as MOE, Schrödinger, OpenEye, or equivalent tools
Familiarity with MD simulation, molecular docking and advanced binding affinity prediction methods (e.g. MM/GBSA, FEP)
Experience with ML-augmented small molecule discovery
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking a skilled and highly motivated Computational Chemist to join our Computational Sciences group at Iambic Therapeutics. You will be a key player in the application of advanced ligand and structure-based techniques to drive our drug discovery efforts. You will play an active role in the research teams pursuing important therapeutics across multiple indications. You will work in a cross-functional team, collaborating closely with machine learning scientists, medicinal chemists and biologists to apply cutting edge SBDD methods across hit identification, lead optimization, and candidate selection phases. This is a hands-on role, requiring technical expertise in computational chemistry, experience with or strong interest in applying modern co-folding approaches, familiarity with the drug discovery process and a proactive drug-hunter mindset. This role will involve engagement in external partnerships.\n\nThis position will be based in our San Diego Headquarters, with exceptions for outstanding candidates to work remotely.\n\n\n\nKEY RESPONSIBILITIES\n\n - Apply a range of ligand and structure-based approaches across hit identification, hit to lead and lead optimization phases (e.g. cheminformatics, pharmacophore modeling, docking and shape-based based virtual screening, de novo molecular design, MD simulation)\n\n - Guide design cycles through the identification of structure-activity relationships and the integration of computational predictions with bioactivity data\n\n - Partner with medicinal chemists to design, evaluate and prioritize virtual libraries, and propose actionable molecular designs\n\n - Partner with ML scientists to integrate SBDD methods with our proprietary transformer-based property prediction technology (Enchant)\n\n - Leverage and evolve our proprietary protein-ligand co-folding technology (NeuralPLexer) to yield novel and actionable structural hypotheses\n\n - Translate scientific questions into computational workflows and deliver actionable results\n\n - Present results to internal project teams and external partners, explaining methods, implications and recommendations\n\n - Develop, validate, and maintain computational workflows and tools\n\n\n\nQUALIFICATIONS\n\nRequired:\n\n - PhD or equivalent degree in computational chemistry (or related field) with 2+ years of relevant experience in drug discovery\n\n - Experience supporting active small molecule drug discovery programs\n\n - Experience with ligand and structure based design tools\n\n - Proficiency in Python for scientific computing, data analysis, and computational workflow development\n\n - Excellent written and verbal communication skills; must be able to articulate complex scientific concepts, technical challenges, and results clearly and concisely to diverse audiences.\n\nStrongly preferred:\n\n - Industry experience supporting active drug discovery programs\n\n - Experience with molecular modeling platforms such as MOE, Schrödinger, OpenEye, or equivalent tools\n\n - Familiarity with MD simulation, molecular docking and advanced binding affinity prediction methods (e.g. MM/GBSA, FEP)\n\n - Experience with ML-augmented small molecule discovery\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$124K – $172K • Multiple Ranges","scrapeableCompensationSalarySummary":"$124K - $172K","compensationTiers":[{"id":"1a204b98-11a1-4280-ad23-b2059aaa20ec","tierSummary":"$124K – $156K","title":"Research Scientist II","additionalInformation":null,"components":[{"id":"edf5ed8e-66ed-473a-817e-c240fb0fa22b","summary":"$124K – $156K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":124000,"maxValue":156000}]},{"id":"618ab977-7b7b-41d0-bd0b-5a2e9817e301","tierSummary":"$137K – $172K","title":"Sr Research Scientist","additionalInformation":null,"components":[{"id":"d6ef8fcf-c016-4146-acfb-4a5fd463d106","summary":"$137K – $172K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":137000,"maxValue":172000}]}],"summaryComponents":[{"minValue":124000,"maxValue":172000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"12a04101-8844-4843-90bd-1943c1931768","title":"Director/Senior Director, Immunology ","department":"Science","team":"Biology","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":false,"secondaryLocations":[],"publishedAt":"2026-09-08T16:38:50.685+00:00","isListed":true,"isRemote":null,"workplaceType":null,"address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/12a04101-8844-4843-90bd-1943c1931768","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/12a04101-8844-4843-90bd-1943c1931768/application","descriptionHtml":"JOB SUMMARY
Iambic Therapeutics is seeking a scientific leader with deep expertise in immunology and immunopharmacology to join the Biology group as Director or Senior Director. This individual will define and execute biology strategies for small-molecule discovery programs, translating disease and immune biology into robust in vitro, ex vivo, and in vivo evidence packages that guide medicinal chemistry from hit identification through development candidate nomination and IND-enabling studies. The successful candidate will lead project teams, set scientific direction, and drive cross-functional decision-making with Chemistry, DMPK, Safety, Translational, and Computational teams. The role will also partner with Iambic's AI/ML scientists to apply computational approaches that accelerate hypothesis generation, data interpretation, and program decisions. Level will be determined by experience and demonstrated scope. This role is based at our San Diego headquarters.
KEY RESPONSIBILITIES
Program and cross-functional leadership: Lead immunology strategy from target validation and hit identification through lead optimization, development candidate nomination, and IND-enabling studies, integrating disease biology with SAR, DMPK/PK/PD, safety, target engagement, and translational biomarkers.
In vitro and ex vivo strategy: Oversee disease-relevant studies using primary human immune cells, whole blood/PBMCs, and tissues to assess mechanism, potency, selectivity, target engagement, and immune function while accounting for donor variability and biological context.
In vivo and translational strategy: Define and oversee efficacy, mechanistic, and PK/PD studies, including model and species selection, endpoints, exposure-response relationships, tissue pharmacology, and translation to human biomarkers; critically interpret results.
Team and partner leadership: Manage and develop scientists and associates, oversee CROs and other partners, and ensure clear goals, timelines, budgets, deliverables, data quality, and appropriate SOP- and GLP-aligned practices while fostering an inclusive, high-trust team.
QUALIFICATIONS
PhD in immunology or a related field, with substantial immunology training and typically 15+ years of relevant experience, including significant industry experience in small-molecule discovery.
Track record leading cross-functional small-molecule programs from hit identification through development candidate nomination, with ownership of biology strategy, stage gates, and milestones; IND-enabling experience is valued.
Deep expertise in innate and/or adaptive immunology and extensive experience with primary-cell and ex vivo studies, including multiparameter flow cytometry and relevant functional readouts.
Experience designing and interpreting in vivo efficacy, pharmacodynamic, and mechanistic studies, including model selection, PK/PD, species translation, and biomarker strategy.
Experience developing and transferring robust assay cascades to CROs or automation/HTS platforms, using orthogonal assays and counterscreens to confirm on-target activity and control for donor variability and assay artifacts.
Strong people leadership and executive communication skills, including mentoring, performance management, team development, and data-driven recommendations.
PREFERRED QUALIFICATIONS
Experience using patient-derived samples, translational biomarkers, and high-dimensional data to bridge preclinical and clinical studies.
Familiarity with AI/ML-enabled drug discovery and collaboration with computational biology, data science, or cheminformatics teams.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry-leading competitive pay, company-paid healthcare, flexible spending accounts, voluntary life insurance, 401(k) matching, and uncapped vacation to our team. We are in a brand-new, state-of-the-art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nIambic Therapeutics is seeking a scientific leader with deep expertise in immunology and immunopharmacology to join the Biology group as Director or Senior Director. This individual will define and execute biology strategies for small-molecule discovery programs, translating disease and immune biology into robust in vitro, ex vivo, and in vivo evidence packages that guide medicinal chemistry from hit identification through development candidate nomination and IND-enabling studies. The successful candidate will lead project teams, set scientific direction, and drive cross-functional decision-making with Chemistry, DMPK, Safety, Translational, and Computational teams. The role will also partner with Iambic's AI/ML scientists to apply computational approaches that accelerate hypothesis generation, data interpretation, and program decisions. Level will be determined by experience and demonstrated scope. This role is based at our San Diego headquarters.\n\n\n\nKEY RESPONSIBILITIES\n\n - Program and cross-functional leadership: Lead immunology strategy from target validation and hit identification through lead optimization, development candidate nomination, and IND-enabling studies, integrating disease biology with SAR, DMPK/PK/PD, safety, target engagement, and translational biomarkers.\n\n - In vitro and ex vivo strategy: Oversee disease-relevant studies using primary human immune cells, whole blood/PBMCs, and tissues to assess mechanism, potency, selectivity, target engagement, and immune function while accounting for donor variability and biological context.\n\n - In vivo and translational strategy: Define and oversee efficacy, mechanistic, and PK/PD studies, including model and species selection, endpoints, exposure-response relationships, tissue pharmacology, and translation to human biomarkers; critically interpret results.\n\n - Team and partner leadership: Manage and develop scientists and associates, oversee CROs and other partners, and ensure clear goals, timelines, budgets, deliverables, data quality, and appropriate SOP- and GLP-aligned practices while fostering an inclusive, high-trust team.\n\n\n\nQUALIFICATIONS\n\n - PhD in immunology or a related field, with substantial immunology training and typically 15+ years of relevant experience, including significant industry experience in small-molecule discovery.\n\n - Track record leading cross-functional small-molecule programs from hit identification through development candidate nomination, with ownership of biology strategy, stage gates, and milestones; IND-enabling experience is valued.\n\n - Deep expertise in innate and/or adaptive immunology and extensive experience with primary-cell and ex vivo studies, including multiparameter flow cytometry and relevant functional readouts.\n\n - Experience designing and interpreting in vivo efficacy, pharmacodynamic, and mechanistic studies, including model selection, PK/PD, species translation, and biomarker strategy.\n\n - Experience developing and transferring robust assay cascades to CROs or automation/HTS platforms, using orthogonal assays and counterscreens to confirm on-target activity and control for donor variability and assay artifacts.\n\n - Strong people leadership and executive communication skills, including mentoring, performance management, team development, and data-driven recommendations.\n\n\n\nPREFERRED QUALIFICATIONS\n\n - Experience using patient-derived samples, translational biomarkers, and high-dimensional data to bridge preclinical and clinical studies.\n\n - Familiarity with AI/ML-enabled drug discovery and collaboration with computational biology, data science, or cheminformatics teams.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry-leading competitive pay, company-paid healthcare, flexible spending accounts, voluntary life insurance, 401(k) matching, and uncapped vacation to our team. We are in a brand-new, state-of-the-art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":null,"scrapeableCompensationSalarySummary":null,"compensationTiers":[],"summaryComponents":[]}},{"id":"f419dff6-005a-4adb-832b-d14b3be3eb19","title":"Associate Director / Director, Regulatory Affairs - CMC","department":"Clinical","team":"Clinical Development","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-08-14T02:48:39.901+00:00","isListed":true,"isRemote":null,"workplaceType":null,"address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/f419dff6-005a-4adb-832b-d14b3be3eb19","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/f419dff6-005a-4adb-832b-d14b3be3eb19/application","descriptionHtml":"JOB SUMMARY
The Associate Director/Director of Regulatory Affairs - Chemistry, Manufacturing and Controls (CMC) will lead global CMC regulatory strategy and execution across Iambic's development programs. The role will prepare and oversee high-quality CMC content for regulatory submissions, provide phase-appropriate regulatory guidance, identify and mitigate risks, and ensure alignment with program objectives and global requirements. This individual will partner closely with Technical Operations, Process Chemistry, Analytical Development, Formulation, Manufacturing, Quality, Clinical, Nonclinical, Regulatory Operations, and external partners, and will support interactions with the US FDA and other global health authorities as appropriate. Level will be determined by education, depth of CMC regulatory experience, leadership, and scope of prior responsibilities.
This position will be hybrid and based in our San Diego Headquarters.
KEY RESPONSIBILITIES
Develop and execute global CMC regulatory strategies for drug substance, drug product, analytical methods, manufacturing processes, controls, specifications, stability, packaging, and lifecycle activities.
Lead the planning, authoring, review, coordination, and timely delivery of CMC content for INDs, CTAs, amendments, annual reports, briefing packages, health authority responses, and other global filings.
Partner with Technical Operations, Process Chemistry, Analytical Development, Formulation, Manufacturing, Quality, Clinical, Nonclinical, Regulatory Operations, and external development and manufacturing organizations to ensure integrated CMC plans.
Provide regulatory guidance on phase-appropriate control strategies, comparability, specifications, stability, manufacturing changes, technology transfer, process validation, and later-stage readiness.
Represent Iambic in certain CMC-focused interactions with the US FDA and global health authorities, including meeting preparation, briefing materials, responses, and commitments.
Monitor global CMC regulations, identify CMC regulatory risks, gaps, and dependencies; develop mitigation strategies and communicate collected intelligence, precedence and potential impacts on program timelines, submission plans, and product development decisions.
Support due diligence, external partnerships, vendor oversight, and fit-for-purpose planning for CMC regulatory capabilities, systems, consultants, and headcount.
Develop and maintain relevant standard operating procedures and perform all duties in alignment with Iambic's core values, policies, quality systems, and applicable regulations.
QUALIFICATIONS
Bachelor's degree in chemistry, biochemistry, pharmaceutical sciences, chemical engineering, or a related discipline; advanced degree preferred. Typically 8+ years of relevant pharmaceutical or biotechnology experience for Associate Director and 10+ years for Director, including substantial CMC regulatory affairs experience. Equivalent combinations of education and experience may be considered.
Demonstrated experience developing CMC regulatory strategy and preparing or reviewing Module 3/Quality content for clinical-stage submissions; small-molecule experience is preferred.
Ability to manage multiple programs and workstreams, establish priorities, maintain submission timelines, and deliver high-quality work in a fast-paced, dynamic, cross-functional environment.
Strong knowledge of global CMC requirements and guidance, including FDA and ICH expectations
Excellent scientific writing, communication, collaboration, project management, and problem-solving skills; strong attention to detail
Proficiency with regulatory document/submission tools, including regulatory information management, publishing and analysis tools and Microsoft Office.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nThe Associate Director/Director of Regulatory Affairs - Chemistry, Manufacturing and Controls (CMC) will lead global CMC regulatory strategy and execution across Iambic's development programs. The role will prepare and oversee high-quality CMC content for regulatory submissions, provide phase-appropriate regulatory guidance, identify and mitigate risks, and ensure alignment with program objectives and global requirements. This individual will partner closely with Technical Operations, Process Chemistry, Analytical Development, Formulation, Manufacturing, Quality, Clinical, Nonclinical, Regulatory Operations, and external partners, and will support interactions with the US FDA and other global health authorities as appropriate. Level will be determined by education, depth of CMC regulatory experience, leadership, and scope of prior responsibilities.\n\nThis position will be hybrid and based in our San Diego Headquarters.\n\nKEY RESPONSIBILITIES\n\n - Develop and execute global CMC regulatory strategies for drug substance, drug product, analytical methods, manufacturing processes, controls, specifications, stability, packaging, and lifecycle activities.\n\n - Lead the planning, authoring, review, coordination, and timely delivery of CMC content for INDs, CTAs, amendments, annual reports, briefing packages, health authority responses, and other global filings.\n\n - Partner with Technical Operations, Process Chemistry, Analytical Development, Formulation, Manufacturing, Quality, Clinical, Nonclinical, Regulatory Operations, and external development and manufacturing organizations to ensure integrated CMC plans.\n\n - Provide regulatory guidance on phase-appropriate control strategies, comparability, specifications, stability, manufacturing changes, technology transfer, process validation, and later-stage readiness.\n\n - Represent Iambic in certain CMC-focused interactions with the US FDA and global health authorities, including meeting preparation, briefing materials, responses, and commitments.\n\n - Monitor global CMC regulations, identify CMC regulatory risks, gaps, and dependencies; develop mitigation strategies and communicate collected intelligence, precedence and potential impacts on program timelines, submission plans, and product development decisions.\n\n - Support due diligence, external partnerships, vendor oversight, and fit-for-purpose planning for CMC regulatory capabilities, systems, consultants, and headcount.\n\n - Develop and maintain relevant standard operating procedures and perform all duties in alignment with Iambic's core values, policies, quality systems, and applicable regulations.\n \n \n\nQUALIFICATIONS\n\n - Bachelor's degree in chemistry, biochemistry, pharmaceutical sciences, chemical engineering, or a related discipline; advanced degree preferred. Typically 8+ years of relevant pharmaceutical or biotechnology experience for Associate Director and 10+ years for Director, including substantial CMC regulatory affairs experience. Equivalent combinations of education and experience may be considered.\n\n - Demonstrated experience developing CMC regulatory strategy and preparing or reviewing Module 3/Quality content for clinical-stage submissions; small-molecule experience is preferred.\n\n - Ability to manage multiple programs and workstreams, establish priorities, maintain submission timelines, and deliver high-quality work in a fast-paced, dynamic, cross-functional environment.\n\n - Strong knowledge of global CMC requirements and guidance, including FDA and ICH expectations\n\n - Excellent scientific writing, communication, collaboration, project management, and problem-solving skills; strong attention to detail\n\n - Proficiency with regulatory document/submission tools, including regulatory information management, publishing and analysis tools and Microsoft Office.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\n\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\n\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.\n\n","compensation":{"compensationTierSummary":"$164K – $245K • Multiple Ranges","scrapeableCompensationSalarySummary":"$164K - $245K","compensationTiers":[{"id":"1afc4282-6893-4656-9479-6c14bed1295f","tierSummary":"$164K – $205K","title":"Associate Director","additionalInformation":null,"components":[{"id":"9eb40a36-58d6-4a80-bdcf-14dcb32dc353","summary":"$164K – $205K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":164000,"maxValue":205000}]},{"id":"c2793eec-acc7-4038-8d7f-bfbd959fc4b4","tierSummary":"$196K – $245K","title":"Director","additionalInformation":null,"components":[{"id":"2112180e-6ea6-45a3-b156-ceb8153eefc1","summary":"$196K – $245K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":196000,"maxValue":245000}]}],"summaryComponents":[{"minValue":164000,"maxValue":245000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"955ee88d-3048-406f-80aa-e9b16c7b6a13","title":"Associate Director / Director, Clinical Pharmacology","department":"Clinical","team":"Clinical Development","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[{"location":"Remote - US","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}}}],"publishedAt":"2026-08-20T18:44:11.402+00:00","isListed":true,"isRemote":null,"workplaceType":null,"address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/955ee88d-3048-406f-80aa-e9b16c7b6a13","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/955ee88d-3048-406f-80aa-e9b16c7b6a13/application","descriptionHtml":"JOB SUMMARY
The Associate Director/Director will be responsible for designing and executing clinical pharmacology strategy for oncology small-molecule programs, including PK/PD study design, dose selection and optimization, and the use of modeling and simulation approaches (e.g., PBPK, population PK) to inform program decisions. This role partners closely with Clinical Development, DMPK, Biostatistics, and Regulatory Affairs to author and review protocols and clinical pharmacology sections of regulatory submissions (IND/IMPD, briefing documents, and CTD modules) and to prepare responses to health authority queries. The role also contributes to drug-drug interaction, organ impairment, and cardiac safety (QT) assessment strategies for small-molecule oncology assets, ensuring alignment with current FDA/EMA/ICH guidance (including ICH M12), and may mentor junior scientists within the function.
KEY RESPONSIBILITIES
Represent Clinical Pharmacology line function and work on multi-disciplinary oncology small-molecule program teams (clinical, DMPK, regulatory, biometrics, CMC, etc.), supporting programs from late-stage discovery and IND-enabling activities through Phase 1 dose escalation/expansion and beyond.
Independently analyze, interpret and report clinical PK, PK/PD, and exposure-response data for oncology small-molecule assets as a member of multidisciplinary development program teams.
Partner with Clinical Development to design clinical pharmacology components of oncology studies, including first-in-human dose escalation/expansion, drug-drug interaction, hepatic/renal impairment, food-effect, and cardiac safety (ECG/QT) studies, and combination-therapy dosing strategies.
Apply quantitative approaches (e.g., PBPK, population PK, exposure-response modeling) to inform dose selection and DDI risk assessment, with working knowledge of relevant software (e.g., SimCyp, Phoenix WinNonlin, NONMEM, R) and current regulatory frameworks (e.g., ICH M12, FDA DDI guidance).
Write and review relevant sections of regulatory and scientific documentation including Clinical Study Protocols, IBs, SOPs, Statistical Analysis Plans and Clinical Study Reports.
Maintain a working knowledge of pharmacology, biology, therapeutics, drug metabolism, bioanalysis, and biopharmaceutics.
Review and author scientific publications, abstracts, posters
Maintain a positive, results-orientated work environment, building partnerships and modeling teamwork, and communicating to the team in an open, balanced and objective manner.
QUALIFICATIONS
PhD or equivalent in Pharmacology/Biomedicine/Biochemistry or related scientific discipline with a minimum 5 years of relevant experience within a pharmaceutical industry, contract research, or clinical research.
Experience with clinical development of oncology small-molecule therapeutics is highly desirable, including familiarity with dose-escalation/expansion trial designs and combination-therapy regimens.
Proficiency using Phoenix Winnonlin for non-compartmental analysis
Working knowledge of PBPK modeling and current DDI regulatory frameworks (e.g., ICH M12, FDA guidance) is highly desirable.
Hands on clinical pharmacology related work experience in regulatory and scientific documentation writing including Clinical Study Protocols, SOPs, Statistical Analysis Plans and Clinical Study Reports, as well as regulatory documents.
Familiarity with PK bioanalytical methods development and validation is an asset
Ability to manage multiple projects, prioritize work effectively to meet deadlines, anticipate potential problems within project plans and effectively communicate alternatives.
Strong communication skills, with the ability to work collaboratively as a member of a cross-functional team.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nThe Associate Director/Director will be responsible for designing and executing clinical pharmacology strategy for oncology small-molecule programs, including PK/PD study design, dose selection and optimization, and the use of modeling and simulation approaches (e.g., PBPK, population PK) to inform program decisions. This role partners closely with Clinical Development, DMPK, Biostatistics, and Regulatory Affairs to author and review protocols and clinical pharmacology sections of regulatory submissions (IND/IMPD, briefing documents, and CTD modules) and to prepare responses to health authority queries. The role also contributes to drug-drug interaction, organ impairment, and cardiac safety (QT) assessment strategies for small-molecule oncology assets, ensuring alignment with current FDA/EMA/ICH guidance (including ICH M12), and may mentor junior scientists within the function.\n\n\n\nKEY RESPONSIBILITIES\n\n - Represent Clinical Pharmacology line function and work on multi-disciplinary oncology small-molecule program teams (clinical, DMPK, regulatory, biometrics, CMC, etc.), supporting programs from late-stage discovery and IND-enabling activities through Phase 1 dose escalation/expansion and beyond.\n\n - Independently analyze, interpret and report clinical PK, PK/PD, and exposure-response data for oncology small-molecule assets as a member of multidisciplinary development program teams.\n\n - Partner with Clinical Development to design clinical pharmacology components of oncology studies, including first-in-human dose escalation/expansion, drug-drug interaction, hepatic/renal impairment, food-effect, and cardiac safety (ECG/QT) studies, and combination-therapy dosing strategies.\n\n - Apply quantitative approaches (e.g., PBPK, population PK, exposure-response modeling) to inform dose selection and DDI risk assessment, with working knowledge of relevant software (e.g., SimCyp, Phoenix WinNonlin, NONMEM, R) and current regulatory frameworks (e.g., ICH M12, FDA DDI guidance).\n\n - Write and review relevant sections of regulatory and scientific documentation including Clinical Study Protocols, IBs, SOPs, Statistical Analysis Plans and Clinical Study Reports.\n\n - Maintain a working knowledge of pharmacology, biology, therapeutics, drug metabolism, bioanalysis, and biopharmaceutics.\n\n - Review and author scientific publications, abstracts, posters\n\n - Maintain a positive, results-orientated work environment, building partnerships and modeling teamwork, and communicating to the team in an open, balanced and objective manner.\n\n\n\nQUALIFICATIONS\n\n - PhD or equivalent in Pharmacology/Biomedicine/Biochemistry or related scientific discipline with a minimum 5 years of relevant experience within a pharmaceutical industry, contract research, or clinical research.\n\n - Experience with clinical development of oncology small-molecule therapeutics is highly desirable, including familiarity with dose-escalation/expansion trial designs and combination-therapy regimens.\n\n - Proficiency using Phoenix Winnonlin for non-compartmental analysis\n\n - Working knowledge of PBPK modeling and current DDI regulatory frameworks (e.g., ICH M12, FDA guidance) is highly desirable.\n\n - Hands on clinical pharmacology related work experience in regulatory and scientific documentation writing including Clinical Study Protocols, SOPs, Statistical Analysis Plans and Clinical Study Reports, as well as regulatory documents.\n\n - Familiarity with PK bioanalytical methods development and validation is an asset\n\n - Ability to manage multiple projects, prioritize work effectively to meet deadlines, anticipate potential problems within project plans and effectively communicate alternatives.\n\n - Strong communication skills, with the ability to work collaboratively as a member of a cross-functional team.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$164K – $245K • Multiple Ranges","scrapeableCompensationSalarySummary":"$164K - $245K","compensationTiers":[{"id":"31547024-97a8-452e-ad12-124e63b75d16","tierSummary":"$164K – $205K","title":"Associate Director","additionalInformation":null,"components":[{"id":"d4981ca7-4c3a-4946-a7ca-16a819dabfa5","summary":"$164K – $205K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":164000,"maxValue":205000}]},{"id":"c5a781db-949f-4967-81f3-600212135619","tierSummary":"$196K – $245K","title":"Director","additionalInformation":null,"components":[{"id":"a6327472-d555-4a2c-9a77-9f6ee3d5bfa1","summary":"$196K – $245K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":196000,"maxValue":245000}]}],"summaryComponents":[{"minValue":164000,"maxValue":245000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"41e94f6a-c5ea-4c52-b527-e2976a08347d","title":"Research Scientist I/II, Immunology","department":"Science","team":"Biology","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-08-17T18:47:47.989+00:00","isListed":true,"isRemote":null,"workplaceType":null,"address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/41e94f6a-c5ea-4c52-b527-e2976a08347d","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/41e94f6a-c5ea-4c52-b527-e2976a08347d/application","descriptionHtml":"JOB SUMMARY
We are seeking a highly motivated, hands-on Research Scientist I/II with strong immunology training to join the Biology group and support small-molecule drug discovery programs at Iambic Therapeutics. The successful candidate will design and execute in vitro and ex vivo studies that generate high-quality data for target validation, hit-to-lead, lead optimization, and development candidate selection. The candidate will collaborate closely with colleagues in biology, medicinal chemistry, DMPK, in vivo pharmacology, computational biology, machine learning, and compound management groups. This role is based at our San Diego headquarters.
KEY RESPONSIBILITIES
Design, develop, optimize, troubleshoot, and execute assays using disease-relevant immune cells and tissues, including primary human and/or pre-clinical immune cells, whole blood, cell lines, and tissue-derived systems, to measure potency, selectivity, target engagement, mechanism of action, and functional immune responses.
Run recurring compound-profiling assays and generate timely, reproducible data to support medicinal chemistry design-make-test-analyze cycles from hit-to-lead through lead optimization and development candidate selection.
Apply quantitative pharmacology and rigorous data-quality practices to analyze concentration-response relationships, assay performance, reproducibility, and biological relevance.
Maintain accurate electronic laboratory records, protocols, and data packages; communicate results, technical risks, and recommended next experiments at biology and project-team meetings.
Support in vivo immunology studies by contributing to experimental plans and readout selection, processing study samples, conducting ex vivo analyses, and interpreting exposure, PK/PD, biomarker, and efficacy data with in vivo pharmacology and DMPK colleagues.
Support assay transfer and external studies with CROs or collaborators by executing internal bridging work, reviewing protocols and data, and troubleshooting technical issues.
Contribute to laboratory operations, reagent and instrument qualification, method documentation, and a culture of scientific rigor, safety, collaboration, and timely execution.
QUALIFICATIONS
PhD in immunology or a related field, or another biological discipline with immunology-focused postdoctoral training, plus 0–4 years of relevant experience; or MS with 7+ years / BS with 9+ years of relevant experience.
Strong knowledge of innate and/or adaptive immunology, immune-cell signaling, and disease-relevant mechanisms, with the ability to translate biological questions into well-controlled experiments.
Strong hands-on experience designing and executing in vitro and ex vivo immunology studies using primary human and/or animal immune cells, whole blood, or tissue-based systems, with proficiency in multiparameter flow cytometry, cytokine/chemokine assays, and complementary functional or molecular readouts.
Ability to develop, troubleshoot, and document robust cell-based assay cascades using appropriate controls, counterscreens, and orthogonal readouts to confirm on-target activity and generate reproducible compound-profiling data; experience transferring assays to CROs or automated/HTS platforms is preferred.
Experience supporting small-molecule discovery through compound screening or profiling; exposure to hit identification, hit-to-lead, or lead optimization is preferred.
Working knowledge of in vivo immunology and pharmacology, including model selection, dosing, endpoints, tissue collection, PK/PD, and pharmacodynamic biomarkers; direct hands-on experience is a plus.
Demonstrated scientific rigor, sound experimental judgment, strong organization and communication, and enthusiasm for a collaborative, bench-focused role.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry-leading competitive pay, company-paid healthcare, flexible spending accounts, voluntary life insurance, 401(k) matching, and uncapped vacation to our team. We are in a brand-new, state-of-the-art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking a highly motivated, hands-on Research Scientist I/II with strong immunology training to join the Biology group and support small-molecule drug discovery programs at Iambic Therapeutics. The successful candidate will design and execute in vitro and ex vivo studies that generate high-quality data for target validation, hit-to-lead, lead optimization, and development candidate selection. The candidate will collaborate closely with colleagues in biology, medicinal chemistry, DMPK, in vivo pharmacology, computational biology, machine learning, and compound management groups. This role is based at our San Diego headquarters.\n\n\n\nKEY RESPONSIBILITIES\n\n - Design, develop, optimize, troubleshoot, and execute assays using disease-relevant immune cells and tissues, including primary human and/or pre-clinical immune cells, whole blood, cell lines, and tissue-derived systems, to measure potency, selectivity, target engagement, mechanism of action, and functional immune responses.\n\n - Run recurring compound-profiling assays and generate timely, reproducible data to support medicinal chemistry design-make-test-analyze cycles from hit-to-lead through lead optimization and development candidate selection.\n\n - Apply quantitative pharmacology and rigorous data-quality practices to analyze concentration-response relationships, assay performance, reproducibility, and biological relevance.\n\n - Maintain accurate electronic laboratory records, protocols, and data packages; communicate results, technical risks, and recommended next experiments at biology and project-team meetings.\n\n - Support in vivo immunology studies by contributing to experimental plans and readout selection, processing study samples, conducting ex vivo analyses, and interpreting exposure, PK/PD, biomarker, and efficacy data with in vivo pharmacology and DMPK colleagues.\n\n - Support assay transfer and external studies with CROs or collaborators by executing internal bridging work, reviewing protocols and data, and troubleshooting technical issues.\n\n - Contribute to laboratory operations, reagent and instrument qualification, method documentation, and a culture of scientific rigor, safety, collaboration, and timely execution.\n\n\n\nQUALIFICATIONS\n\n - PhD in immunology or a related field, or another biological discipline with immunology-focused postdoctoral training, plus 0–4 years of relevant experience; or MS with 7+ years / BS with 9+ years of relevant experience.\n\n - Strong knowledge of innate and/or adaptive immunology, immune-cell signaling, and disease-relevant mechanisms, with the ability to translate biological questions into well-controlled experiments.\n\n - Strong hands-on experience designing and executing in vitro and ex vivo immunology studies using primary human and/or animal immune cells, whole blood, or tissue-based systems, with proficiency in multiparameter flow cytometry, cytokine/chemokine assays, and complementary functional or molecular readouts.\n\n - Ability to develop, troubleshoot, and document robust cell-based assay cascades using appropriate controls, counterscreens, and orthogonal readouts to confirm on-target activity and generate reproducible compound-profiling data; experience transferring assays to CROs or automated/HTS platforms is preferred.\n\n - Experience supporting small-molecule discovery through compound screening or profiling; exposure to hit identification, hit-to-lead, or lead optimization is preferred.\n\n - Working knowledge of in vivo immunology and pharmacology, including model selection, dosing, endpoints, tissue collection, PK/PD, and pharmacodynamic biomarkers; direct hands-on experience is a plus.\n\n - Demonstrated scientific rigor, sound experimental judgment, strong organization and communication, and enthusiasm for a collaborative, bench-focused role.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry-leading competitive pay, company-paid healthcare, flexible spending accounts, voluntary life insurance, 401(k) matching, and uncapped vacation to our team. We are in a brand-new, state-of-the-art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$113K – $156K • Multiple Ranges","scrapeableCompensationSalarySummary":"$113K - $156K","compensationTiers":[{"id":"e1adaf8b-1e5e-4792-9f32-04e3747bb92f","tierSummary":"$113K – $142K","title":"Research Scientist I","additionalInformation":null,"components":[{"id":"b0f9866b-4500-4aff-ae56-c97b96ef668e","summary":"$113K – $142K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":113000,"maxValue":142000}]},{"id":"4e672767-d1c0-4363-b0a1-08c8551a1574","tierSummary":"$124K – $156K","title":"Research Scientist II","additionalInformation":null,"components":[{"id":"e9781f51-dd3f-40dd-86e5-01dfa3ef9f57","summary":"$124K – $156K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":124000,"maxValue":156000}]}],"summaryComponents":[{"minValue":113000,"maxValue":156000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"4a04c67c-1be5-4109-8f9f-b3e8dd818e37","title":"Research Scientist I/II, Bioanalytical Sciences & Assay Development","department":"Science","team":"Analytical","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-08-31T16:49:19.733+00:00","isListed":true,"isRemote":null,"workplaceType":null,"address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/4a04c67c-1be5-4109-8f9f-b3e8dd818e37","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/4a04c67c-1be5-4109-8f9f-b3e8dd818e37/application","descriptionHtml":"JOB SUMMARY
We are seeking a highly motivated Research Scientist, Bioanalytical Sciences & Assay Development to join our drug discovery team. This scientist will develop and implement mass spectrometry-based assays and bioanalytical workflows supporting Hit Identification (HitID), ADME/DMPK characterization, and physicochemical property assessment. A key focus will be the development and application of MS-based screening approaches for HitID, including Affinity Selection Mass Spectrometry (ASMS) and other MS-based capabilities.
The ideal candidate will have a strong foundation in bioanalytical science, mass spectrometry, and assay development, with the ability to develop robust and scalable assays for small-molecule drug discovery. This scientist will work at the interface of experimental science, automation, and AI-driven molecular design, generating high-quality data that inform compound optimization and enable rapid design–make–test–learn cycles. This position will be based in our San Diego Headquarters.
KEY RESPONSIBILITIES
Develop and implement MS-based assays and screening workflows for HitID, including ASMS and other MS-based approaches.
Develop fit-for-purpose bioanalytical and biochemical assays supporting screening, hit confirmation, and compound characterization.
Develop and execute in vitro ADME/DMPK assays, including metabolic stability, permeability, protein binding, and related endpoints.
Develop physicochemical property assays, including solubility, logD/lipophilicity, ePSA, and related measurements.
Develop and optimize LC-MS/MS bioanalytical methods and troubleshoot assay performance, sensitivity, selectivity, matrix effects, and reproducibility.
Develop automated and high-throughput assay workflows to improve capacity, turnaround time, and data quality.
Support operation and troubleshooting of MS and LC/MS instrumentation and associated laboratory automation.
Generate high-quality experimental datasets that support AI/ML-driven compound design and optimization.
Collaborate with biology, screening/HitID, medicinal chemistry, DMPK, and computational/AI teams to design assay strategies and translate experimental results into actionable insights.
Evaluate new assay technologies, MS methodologies, automation solutions, and data workflows to expand drug discovery capabilities.
QUALIFICATIONS
Ph.D. in Bioanalytical Chemistry, Mass Spectrometry, Chemical Biology, Drug Metabolism/Pharmacokinetics, Pharmaceutical Sciences, Biochemistry, or a related discipline, with approximately 0–5 years of relevant experience; or an M.S. with significant relevant industry experience.
Strong foundation in mass spectrometry, bioanalytical science, and assay development, preferably with hands-on LC-MS/MS experience.
Demonstrated experience developing, optimizing, and troubleshooting bioanalytical, biochemical, or screening assays.
Strong understanding of quantitative assay design, experimental controls, data quality, and troubleshooting.
Strong scientific problem-solving and collaboration skills, with an interest in connecting experimental data with AI/ML-enabled drug discovery and molecular design.
PREFERRED QUALIFICATIONS
Experience with MS-based screening or HitID approaches, including ASMS or related technologies, is highly desirable.
Experience with in vitro ADME/DMPK and/or physicochemical property assays such as solubility, logD, and ePSA is preferred.
Experience with SCIEX, Agilent, Thermo, or comparable MS/LC-MS platforms is desirable.
Experience with laboratory automation, high-throughput screening/experimentation, or automated data processing is a plus.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking a highly motivated Research Scientist, Bioanalytical Sciences & Assay Development to join our drug discovery team. This scientist will develop and implement mass spectrometry-based assays and bioanalytical workflows supporting Hit Identification (HitID), ADME/DMPK characterization, and physicochemical property assessment. A key focus will be the development and application of MS-based screening approaches for HitID, including Affinity Selection Mass Spectrometry (ASMS) and other MS-based capabilities.\n\n\n\nThe ideal candidate will have a strong foundation in bioanalytical science, mass spectrometry, and assay development, with the ability to develop robust and scalable assays for small-molecule drug discovery. This scientist will work at the interface of experimental science, automation, and AI-driven molecular design, generating high-quality data that inform compound optimization and enable rapid design–make–test–learn cycles. This position will be based in our San Diego Headquarters.\n\n\n\nKEY RESPONSIBILITIES\n\n - Develop and implement MS-based assays and screening workflows for HitID, including ASMS and other MS-based approaches.\n\n - Develop fit-for-purpose bioanalytical and biochemical assays supporting screening, hit confirmation, and compound characterization.\n\n - Develop and execute in vitro ADME/DMPK assays, including metabolic stability, permeability, protein binding, and related endpoints.\n\n - Develop physicochemical property assays, including solubility, logD/lipophilicity, ePSA, and related measurements.\n\n - Develop and optimize LC-MS/MS bioanalytical methods and troubleshoot assay performance, sensitivity, selectivity, matrix effects, and reproducibility.\n\n - Develop automated and high-throughput assay workflows to improve capacity, turnaround time, and data quality.\n\n - Support operation and troubleshooting of MS and LC/MS instrumentation and associated laboratory automation.\n\n - Generate high-quality experimental datasets that support AI/ML-driven compound design and optimization.\n\n - Collaborate with biology, screening/HitID, medicinal chemistry, DMPK, and computational/AI teams to design assay strategies and translate experimental results into actionable insights.\n\n - Evaluate new assay technologies, MS methodologies, automation solutions, and data workflows to expand drug discovery capabilities.\n\n\n\nQUALIFICATIONS\n\n - Ph.D. in Bioanalytical Chemistry, Mass Spectrometry, Chemical Biology, Drug Metabolism/Pharmacokinetics, Pharmaceutical Sciences, Biochemistry, or a related discipline, with approximately 0–5 years of relevant experience; or an M.S. with significant relevant industry experience.\n\n - Strong foundation in mass spectrometry, bioanalytical science, and assay development, preferably with hands-on LC-MS/MS experience.\n\n - Demonstrated experience developing, optimizing, and troubleshooting bioanalytical, biochemical, or screening assays.\n\n - Strong understanding of quantitative assay design, experimental controls, data quality, and troubleshooting.\n\n - Strong scientific problem-solving and collaboration skills, with an interest in connecting experimental data with AI/ML-enabled drug discovery and molecular design.\n\nPREFERRED QUALIFICATIONS\n\n - Experience with MS-based screening or HitID approaches, including ASMS or related technologies, is highly desirable.\n\n - Experience with in vitro ADME/DMPK and/or physicochemical property assays such as solubility, logD, and ePSA is preferred.\n\n - Experience with SCIEX, Agilent, Thermo, or comparable MS/LC-MS platforms is desirable.\n\n - Experience with laboratory automation, high-throughput screening/experimentation, or automated data processing is a plus.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$113.6K – $156K • Multiple Ranges","scrapeableCompensationSalarySummary":"$113.6K - $156K","compensationTiers":[{"id":"28e1131c-ca23-44bd-ab2d-0afc99171a89","tierSummary":"$113.6K – $142K","title":"Reseach Scientist I","additionalInformation":null,"components":[{"id":"e4dcb0d3-3d86-41c9-9faf-87722a44f41d","summary":"$113.6K – $142K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":113600,"maxValue":142000}]},{"id":"749b4065-c333-4488-b2cf-8dcd9dd724ea","tierSummary":"$124.8K – $156K","title":"Research Scientist II","additionalInformation":null,"components":[{"id":"d219901a-4568-4a56-bee2-afa56c036670","summary":"$124.8K – $156K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":124800,"maxValue":156000}]}],"summaryComponents":[{"minValue":113600,"maxValue":156000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"50be2fab-54c1-4310-8cec-3fe6123b8a8f","title":"Machine Learning Scientist — Large Multimodal Models (Post-Training)","department":"Technology","team":"Machine Learning","employmentType":"FullTime","location":"Boston Office","shouldDisplayCompensationOnJobPostings":false,"secondaryLocations":[],"publishedAt":"2026-08-27T21:35:30.736+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"MA","addressCountry":"US","addressLocality":"Boston"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/50be2fab-54c1-4310-8cec-3fe6123b8a8f","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/50be2fab-54c1-4310-8cec-3fe6123b8a8f/application","descriptionHtml":"JOB SUMMARY
We are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. Our mission is to deliver better medicines through innovation in AI-based discovery technologies. In this role, you will research and develop post-training methods for Enchant - our multimodal transformer model trained on a wide variety of biomedical data - pushing the boundaries of what large-scale foundation models can achieve in drug discovery.
The role centers on designing and evaluating post-training approaches for large multimodal language models including supervised fine-tuning, parameter-efficient fine-tuning, reinforcement learning, preference or reward-based optimization, and other emerging post-training methods. You will develop rigorous evaluations and training infrastructure that make it possible to rapidly iterate on these approaches at scale and work closely with colleagues across machine learning, software engineering, and drug discovery to put powerful foundation models into the hands of scientists making real therapeutic decisions.
We are hiring across multiple levels and welcome candidates ranging from recent PhD graduates to experienced researchers with a strong publication or deployment record. This is a remote position, with the option to be on-site in our Boston office.
KEY RESPONSIBILITIES
Research and develop post-training strategies for large-scale multimodal foundation models
Design reward functions, training objectives, data-generation strategies, and evaluation protocols for reinforcement learning and other post-training approaches applied to multimodal LLMs
Build systematic experimentation and hyperparameter optimization workflows to efficiently explore post-training recipes, model configurations, and training strategies
Develop and apply inference optimization techniques to support deployment in both high-throughput model evaluation and interactive discovery workflows
Design and maintain rigorous benchmarking and evaluation frameworks that measure model quality across modalities, downstream tasks, and scientific use cases
Collaborate with ML and software engineering colleagues to productionize models, evaluation systems, and inference services
Partner with computational chemists, medicinal chemists, and biologists to ensure model development and post-training objectives are grounded in drug discovery needs
Communicate results to internal teams, external partners, and at conferences
Write high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity
QUALIFICATIONS
PhD in machine learning, computer science, computational chemistry, physics, or a related computational STEM field, or equivalent industry experience demonstrating comparable depth
Strong Python and PyTorch skills, including implementing, training, debugging and evaluating deep learning models end-to-end
Demonstrated experience training large-scale transformer models
Demonstrated experience in one or more of the following:
Reinforcement learning approaches such as RLHF, RLAIF, PPO, GRPO, RL with verifiable rewards, or related methods (strongly preferred)
Supervised fine-tuning, full-parameter fine-tuning, parameter-efficient fine-tuning (LoRA), or related methods
Systematic hyperparameter optimization or large-scale experimentation using tools such as Optuna, Ray Tune, or similar frameworks
Strong engineering practices: reproducible experimentation, clean code, testing, and performance-aware debugging
Comfort with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking tools such as Weights & Biases)
PREFERRED
Experience with multimodal or multi-task model architectures
Training and inference optimization (e.g., mixed precision, kernel optimization, quantization, distributed strategies)
Familiarity with biomedical, chemical, or biological data domains
Distributed training at scale
HPC or large-scale training operations experience
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. Our mission is to deliver better medicines through innovation in AI-based discovery technologies. In this role, you will research and develop post-training methods for Enchant - our multimodal transformer model trained on a wide variety of biomedical data - pushing the boundaries of what large-scale foundation models can achieve in drug discovery.\n\nThe role centers on designing and evaluating post-training approaches for large multimodal language models including supervised fine-tuning, parameter-efficient fine-tuning, reinforcement learning, preference or reward-based optimization, and other emerging post-training methods. You will develop rigorous evaluations and training infrastructure that make it possible to rapidly iterate on these approaches at scale and work closely with colleagues across machine learning, software engineering, and drug discovery to put powerful foundation models into the hands of scientists making real therapeutic decisions.\n\nWe are hiring across multiple levels and welcome candidates ranging from recent PhD graduates to experienced researchers with a strong publication or deployment record. This is a remote position, with the option to be on-site in our Boston office.\n\n\n\nKEY RESPONSIBILITIES\n\n - Research and develop post-training strategies for large-scale multimodal foundation models\n\n - Design reward functions, training objectives, data-generation strategies, and evaluation protocols for reinforcement learning and other post-training approaches applied to multimodal LLMs\n\n - Build systematic experimentation and hyperparameter optimization workflows to efficiently explore post-training recipes, model configurations, and training strategies\n\n - Develop and apply inference optimization techniques to support deployment in both high-throughput model evaluation and interactive discovery workflows\n\n - Design and maintain rigorous benchmarking and evaluation frameworks that measure model quality across modalities, downstream tasks, and scientific use cases\n\n - Collaborate with ML and software engineering colleagues to productionize models, evaluation systems, and inference services\n\n - Partner with computational chemists, medicinal chemists, and biologists to ensure model development and post-training objectives are grounded in drug discovery needs\n\n - Communicate results to internal teams, external partners, and at conferences\n\n - Write high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity\n\n\n\nQUALIFICATIONS\n\n - PhD in machine learning, computer science, computational chemistry, physics, or a related computational STEM field, or equivalent industry experience demonstrating comparable depth\n\n - Strong Python and PyTorch skills, including implementing, training, debugging and evaluating deep learning models end-to-end\n\n - Demonstrated experience training large-scale transformer models\n\n - Demonstrated experience in one or more of the following:\n\n - Reinforcement learning approaches such as RLHF, RLAIF, PPO, GRPO, RL with verifiable rewards, or related methods (strongly preferred)\n\n - Supervised fine-tuning, full-parameter fine-tuning, parameter-efficient fine-tuning (LoRA), or related methods\n\n - Systematic hyperparameter optimization or large-scale experimentation using tools such as Optuna, Ray Tune, or similar frameworks\n\n - Strong engineering practices: reproducible experimentation, clean code, testing, and performance-aware debugging\n\n - Comfort with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking tools such as Weights & Biases)\n\nPREFERRED\n\n - Experience with multimodal or multi-task model architectures\n\n - Training and inference optimization (e.g., mixed precision, kernel optimization, quantization, distributed strategies)\n\n - Familiarity with biomedical, chemical, or biological data domains\n\n - Distributed training at scale\n\n - HPC or large-scale training operations experience\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":null,"scrapeableCompensationSalarySummary":null,"compensationTiers":[],"summaryComponents":[]}},{"id":"1232cf39-832c-494f-99b9-1b4ee7266a42","title":"Machine Learning Scientist — Large Multimodal Models (Post-Training)","department":"Technology","team":"Machine Learning","employmentType":"FullTime","location":"UK Office","shouldDisplayCompensationOnJobPostings":false,"secondaryLocations":[],"publishedAt":"2026-08-27T21:37:28.407+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"England","addressCountry":"United Kingdom","addressLocality":"Bristol"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/1232cf39-832c-494f-99b9-1b4ee7266a42","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/1232cf39-832c-494f-99b9-1b4ee7266a42/application","descriptionHtml":"JOB SUMMARY
We are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. Our mission is to deliver better medicines through innovation in AI-based discovery technologies. In this role, you will research and develop post-training methods for Enchant - our multimodal transformer model trained on a wide variety of biomedical data - pushing the boundaries of what large-scale foundation models can achieve in drug discovery.
The role centers on designing and evaluating post-training approaches for large multimodal language models including supervised fine-tuning, parameter-efficient fine-tuning, reinforcement learning, preference or reward-based optimization, and other emerging post-training methods. You will develop rigorous evaluations and training infrastructure that make it possible to rapidly iterate on these approaches at scale and work closely with colleagues across machine learning, software engineering, and drug discovery to put powerful foundation models into the hands of scientists making real therapeutic decisions.
We are hiring across multiple levels and welcome candidates ranging from recent PhD graduates to experienced researchers with a strong publication or deployment record. This is a remote position, with the option to be on-site in our Bristol office.
KEY RESPONSIBILITIES
Research and develop post-training strategies for large-scale multimodal foundation models
Design reward functions, training objectives, data-generation strategies, and evaluation protocols for reinforcement learning and other post-training approaches applied to multimodal LLMs
Build systematic experimentation and hyperparameter optimization workflows to efficiently explore post-training recipes, model configurations, and training strategies
Develop and apply inference optimization techniques to support deployment in both high-throughput model evaluation and interactive discovery workflows
Design and maintain rigorous benchmarking and evaluation frameworks that measure model quality across modalities, downstream tasks, and scientific use cases
Collaborate with ML and software engineering colleagues to productionize models, evaluation systems, and inference services
Partner with computational chemists, medicinal chemists, and biologists to ensure model development and post-training objectives are grounded in drug discovery needs
Communicate results to internal teams, external partners, and at conferences
Write high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity
QUALIFICATIONS
PhD in machine learning, computer science, computational chemistry, physics, or a related computational STEM field, or equivalent industry experience demonstrating comparable depth
Strong Python and PyTorch skills, including implementing, training, debugging and evaluating deep learning models end-to-end
Demonstrated experience training large-scale transformer models
Demonstrated experience in one or more of the following:
Reinforcement learning approaches such as RLHF, RLAIF, PPO, GRPO, RL with verifiable rewards, or related methods (strongly preferred)
Supervised fine-tuning, full-parameter fine-tuning, parameter-efficient fine-tuning (LoRA), or related methods
Systematic hyperparameter optimization or large-scale experimentation using tools such as Optuna, Ray Tune, or similar frameworks
Strong engineering practices: reproducible experimentation, clean code, testing, and performance-aware debugging
Comfort with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking tools such as Weights & Biases)
PREFERRED
Experience with multimodal or multi-task model architectures
Training and inference optimization (e.g., mixed precision, kernel optimization, quantization, distributed strategies)
Familiarity with biomedical, chemical, or biological data domains
Distributed training at scale
HPC or large-scale training operations experience
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer a competitive compensation package, private medical insurance, life assurance, pension contributions, and flexible holiday allowances to our team. Our UK office provides a modern and collaborative work environment, right in the centre of Bristol.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. Our mission is to deliver better medicines through innovation in AI-based discovery technologies. In this role, you will research and develop post-training methods for Enchant - our multimodal transformer model trained on a wide variety of biomedical data - pushing the boundaries of what large-scale foundation models can achieve in drug discovery.\n\nThe role centers on designing and evaluating post-training approaches for large multimodal language models including supervised fine-tuning, parameter-efficient fine-tuning, reinforcement learning, preference or reward-based optimization, and other emerging post-training methods. You will develop rigorous evaluations and training infrastructure that make it possible to rapidly iterate on these approaches at scale and work closely with colleagues across machine learning, software engineering, and drug discovery to put powerful foundation models into the hands of scientists making real therapeutic decisions.\n\nWe are hiring across multiple levels and welcome candidates ranging from recent PhD graduates to experienced researchers with a strong publication or deployment record. This is a remote position, with the option to be on-site in our Bristol office.\n\n\n\nKEY RESPONSIBILITIES\n\n - Research and develop post-training strategies for large-scale multimodal foundation models\n\n - Design reward functions, training objectives, data-generation strategies, and evaluation protocols for reinforcement learning and other post-training approaches applied to multimodal LLMs\n\n - Build systematic experimentation and hyperparameter optimization workflows to efficiently explore post-training recipes, model configurations, and training strategies\n\n - Develop and apply inference optimization techniques to support deployment in both high-throughput model evaluation and interactive discovery workflows\n\n - Design and maintain rigorous benchmarking and evaluation frameworks that measure model quality across modalities, downstream tasks, and scientific use cases\n\n - Collaborate with ML and software engineering colleagues to productionize models, evaluation systems, and inference services\n\n - Partner with computational chemists, medicinal chemists, and biologists to ensure model development and post-training objectives are grounded in drug discovery needs\n\n - Communicate results to internal teams, external partners, and at conferences\n\n - Write high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity\n\n\n\nQUALIFICATIONS\n\n - PhD in machine learning, computer science, computational chemistry, physics, or a related computational STEM field, or equivalent industry experience demonstrating comparable depth\n\n - Strong Python and PyTorch skills, including implementing, training, debugging and evaluating deep learning models end-to-end\n\n - Demonstrated experience training large-scale transformer models\n\n - Demonstrated experience in one or more of the following:\n\n - Reinforcement learning approaches such as RLHF, RLAIF, PPO, GRPO, RL with verifiable rewards, or related methods (strongly preferred)\n\n - Supervised fine-tuning, full-parameter fine-tuning, parameter-efficient fine-tuning (LoRA), or related methods\n\n - Systematic hyperparameter optimization or large-scale experimentation using tools such as Optuna, Ray Tune, or similar frameworks\n\n - Strong engineering practices: reproducible experimentation, clean code, testing, and performance-aware debugging\n\n - Comfort with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking tools such as Weights & Biases)\n\nPREFERRED\n\n - Experience with multimodal or multi-task model architectures\n\n - Training and inference optimization (e.g., mixed precision, kernel optimization, quantization, distributed strategies)\n\n - Familiarity with biomedical, chemical, or biological data domains\n\n - Distributed training at scale\n\n - HPC or large-scale training operations experience\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer a competitive compensation package, private medical insurance, life assurance, pension contributions, and flexible holiday allowances to our team. Our UK office provides a modern and collaborative work environment, right in the centre of Bristol.","compensation":{"compensationTierSummary":null,"scrapeableCompensationSalarySummary":null,"compensationTiers":[],"summaryComponents":[]}},{"id":"cd83cc34-0ac3-411d-b0da-8f37a67d4841","title":"Sr Manager, Quality Systems & Compliance","department":"Clinical","team":"Regulatory","employmentType":"FullTime","location":"Remote - US","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[{"location":"San Diego HQ","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}}}],"publishedAt":"2026-08-31T19:12:02.689+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/cd83cc34-0ac3-411d-b0da-8f37a67d4841","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/cd83cc34-0ac3-411d-b0da-8f37a67d4841/application","descriptionHtml":"JOB SUMMARY
This role will assist in leading activities within Quality Systems and Compliance, with responsibility for designing and implementing a Quality Management System (QMS) that supports current clinical development programs and the organization’s growing pipeline. Quality Systems & Compliance partners closely with Regulatory, Medical, Clinical, R&D, and Technology leadership to ensure quality systems enable innovation, maintain compliance, and support continuous inspection readiness across U.S. and global clinical programs.
This position can be remote based in the US or hybrid based in our San Diego headquarters.
KEY RESPONSIBILITIES
Execute and support ongoing effectiveness of the Quality Management System (QMS).
Work closely with Quality management to manage deviations and investigations, CAPA, change controls, risk assessments, quality events, and effectiveness checks internally and while working with external partners and suppliers/vendors
Create controlled documents and governance frameworks covering core processes from establishment throughout continuous improvement efforts
Support regulatory compliance within drug production activities
Execute a quality roadmap that translates regulatory and quality requirements into practical, scalable operating models aligned with current compliance needs and future organizational growth
Proactively identify and mitigate compliance risk through data-driven monitoring
Foster a culture of accountability, transparency, and quality ownership across the organization
Provide quality oversight and coordination for internal and third-party audits
Prepare the organization for inspection readiness for U.S.-based and global clinical programs through established quality systems, governance, and cross-functional alignment.
QUALIFICATIONS
Bachelor’s degree in a scientific or technical field, such as biology, chemistry, engineering, or related health science, with 6+ years of progressive Quality experience within a GxP-regulated industry
Experience supporting inspection readiness, audits, or regulatory interactions through quality systems and cross-functional collaboration
Experience managing, implementing or improving a Quality Management System
Experience with implementing and maintaining electronic quality management systems (eQMS) such as Veeva, ZenQMS, MasterControl, etc.
Familiarity with global regulatory expectations applicable to clinical development, including U.S. and international considerations.
Working knowledge of GCP and applicable GMP principles as they relate to quality systems
Strong understanding of risk-based quality systems and continuous improvement concepts
Experience partnering and leading cross-functional teams, including Regulatory, CMC, Clinical Operations, Information Technology and R&D
Strong technical writing, organizational, and problem-solving skills.
Demonstrated ability to translate regulatory and quality requirements into practical, scalable processes
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nThis role will assist in leading activities within Quality Systems and Compliance, with responsibility for designing and implementing a Quality Management System (QMS) that supports current clinical development programs and the organization’s growing pipeline. Quality Systems & Compliance partners closely with Regulatory, Medical, Clinical, R&D, and Technology leadership to ensure quality systems enable innovation, maintain compliance, and support continuous inspection readiness across U.S. and global clinical programs.\n\nThis position can be remote based in the US or hybrid based in our San Diego headquarters.\n\n\n\nKEY RESPONSIBILITIES\n\n - Execute and support ongoing effectiveness of the Quality Management System (QMS).\n\n - Work closely with Quality management to manage deviations and investigations, CAPA, change controls, risk assessments, quality events, and effectiveness checks internally and while working with external partners and suppliers/vendors\n\n - Create controlled documents and governance frameworks covering core processes from establishment throughout continuous improvement efforts\n\n - Support regulatory compliance within drug production activities\n\n - Execute a quality roadmap that translates regulatory and quality requirements into practical, scalable operating models aligned with current compliance needs and future organizational growth\n\n - Proactively identify and mitigate compliance risk through data-driven monitoring\n\n - Foster a culture of accountability, transparency, and quality ownership across the organization\n\n - Provide quality oversight and coordination for internal and third-party audits\n\n - Prepare the organization for inspection readiness for U.S.-based and global clinical programs through established quality systems, governance, and cross-functional alignment.\n\n\n\nQUALIFICATIONS\n\n - Bachelor’s degree in a scientific or technical field, such as biology, chemistry, engineering, or related health science, with 6+ years of progressive Quality experience within a GxP-regulated industry\n\n - Experience supporting inspection readiness, audits, or regulatory interactions through quality systems and cross-functional collaboration\n\n - Experience managing, implementing or improving a Quality Management System\n\n - Experience with implementing and maintaining electronic quality management systems (eQMS) such as Veeva, ZenQMS, MasterControl, etc.\n\n - Familiarity with global regulatory expectations applicable to clinical development, including U.S. and international considerations.\n\n - Working knowledge of GCP and applicable GMP principles as they relate to quality systems\n\n - Strong understanding of risk-based quality systems and continuous improvement concepts\n\n - Experience partnering and leading cross-functional teams, including Regulatory, CMC, Clinical Operations, Information Technology and R&D\n\n - Strong technical writing, organizational, and problem-solving skills.\n\n - Demonstrated ability to translate regulatory and quality requirements into practical, scalable processes\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$152K – $190K","scrapeableCompensationSalarySummary":"$152K - $190K","compensationTiers":[{"id":"c945414b-ca4e-4cad-ab91-556099fa6a3a","tierSummary":"$152K – $190K","title":null,"additionalInformation":null,"components":[{"id":"449a31ad-1ebd-49ea-9571-b4841c7c0ba5","summary":"$152K – $190K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":152000,"maxValue":190000}]}],"summaryComponents":[{"compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":152000,"maxValue":190000}]}},{"id":"ed5c9548-a170-4a73-ade7-2f710d009fac","title":"Software Engineer — Agentic data pipelines","department":"Technology","team":"Machine Learning","employmentType":"FullTime","location":"Remote - US","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-09-04T00:46:22.912+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/ed5c9548-a170-4a73-ade7-2f710d009fac","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/ed5c9548-a170-4a73-ade7-2f710d009fac/application","descriptionHtml":"JOB SUMMARY
We are seeking a software engineer to join our team at Iambic Therapeutics, working on data acquisition and curation for Enchant, our multimodal transformer model trained at scale on a wide variety of biomedical data. In this role, you will design and build agentic systems that generate code to acquire, clean, format, quality-control, and generate auditable data reports for the large-scale datasets that power Enchant training. The model writes the code, the code runs the pipeline. You will work at the intersection of LLM-based automation and biomedical data engineering—developing AI agents that can navigate heterogeneous data sources, enforce quality standards, and operate reliably at scale.
This role is ideal for candidates who combine strong software engineering instincts with scientific understanding of biomedical data, and who are excited about using LLMs as tools to solve practical data problems.
KEY RESPONSIBILITIES
Design, build, and maintain agentic systems that turn a pointer to a biomedical data source (web page, S3 path, GitHub repository, a table in a paper) into a reviewed, versioned dataset. The agent's output is committed pipeline code and its test suite, so re-running it later reproduces the same dataset. Develop LLM-based pipelines for data cleaning, normalization, and formatting across diverse data modalities (e.g., molecular, genomic, clinical, literature)
Implement automated quality-control workflows that detect anomalies, flag inconsistencies, and enforce data standards
Evaluate and iterate on agent architectures, prompting strategies, tool definitions, validation loops, and evaluation harnesses that make agent-generated code trustworthy, improving reliability and throughput over time
Collaborate with ML scientists on the Enchant team to understand data requirements and translate them into scalable acquisition and processing systems
Monitor and maintain distributed data pipelines in production, diagnosing failures and improving robustness over time
Document data provenance, processing decisions, and quality metrics to support reproducibility and auditing
Operate the agents safely with sandboxed execution, least-privilege credentials, restricted network access, audit logs, and raising potential security risks to the team
QUALIFICATIONS
Master’s degree in a computational STEM field, or a Bachelor's with 2+ years of industry experience
Strong Python engineering skills, including experience building and maintaining production-quality software
Hands-on experience with LLM APIs (e.g., Claude, GPT) and agentic patterns such as tool use, orchestration, and multi-step reasoning
Familiarity with biomedical or chemical data sources and formats (e.g., PDB, UniProt, ChEMBL, SDF/MOL, FASTA, or similar)
Comfort with data engineering fundamentals: ETL design, data validation, and working with structured and unstructured data at scale
Hands-on experience with Python testing frameworks (e.g., pytest fixtures, parametrization)
PREFERRED QUALIFICATIONS
Experience with agent orchestration frameworks, and with evaluation harnesses for LLM-generated code
Familiarity with cloud infrastructure and workflow orchestration (e.g., AWS, Docker, Kubernetes)
Knowledge of multimodal biomedical data—spanning small molecules, proteins, assays, images, ‘omics, and/or clinical records
Experience with large-scale dataset construction or curation for ML model training
Knowledge of agent security practices: sandboxing, scoped credentials, prompt injection
Interest in a longer-term project: a natural language orchestrator that lets drug prosecution team members request inference, fine-tuning, virtual screens, and dataset analysis without writing code using our internal tools
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking a software engineer to join our team at Iambic Therapeutics, working on data acquisition and curation for Enchant https://www.iambic.ai/post/enchant, our multimodal transformer model trained at scale on a wide variety of biomedical data. In this role, you will design and build agentic systems that generate code to acquire, clean, format, quality-control, and generate auditable data reports for the large-scale datasets that power Enchant training. The model writes the code, the code runs the pipeline. You will work at the intersection of LLM-based automation and biomedical data engineering—developing AI agents that can navigate heterogeneous data sources, enforce quality standards, and operate reliably at scale. \n\nThis role is ideal for candidates who combine strong software engineering instincts with scientific understanding of biomedical data, and who are excited about using LLMs as tools to solve practical data problems.\n\n\n\nKEY RESPONSIBILITIES\n\n - Design, build, and maintain agentic systems that turn a pointer to a biomedical data source (web page, S3 path, GitHub repository, a table in a paper) into a reviewed, versioned dataset. The agent's output is committed pipeline code and its test suite, so re-running it later reproduces the same dataset. Develop LLM-based pipelines for data cleaning, normalization, and formatting across diverse data modalities (e.g., molecular, genomic, clinical, literature)\n\n - Implement automated quality-control workflows that detect anomalies, flag inconsistencies, and enforce data standards\n\n - Evaluate and iterate on agent architectures, prompting strategies, tool definitions, validation loops, and evaluation harnesses that make agent-generated code trustworthy, improving reliability and throughput over time\n\n - Collaborate with ML scientists on the Enchant team to understand data requirements and translate them into scalable acquisition and processing systems\n\n - Monitor and maintain distributed data pipelines in production, diagnosing failures and improving robustness over time\n\n - Document data provenance, processing decisions, and quality metrics to support reproducibility and auditing\n\n - Operate the agents safely with sandboxed execution, least-privilege credentials, restricted network access, audit logs, and raising potential security risks to the team\n\n\n\nQUALIFICATIONS\n\n - Master’s degree in a computational STEM field, or a Bachelor's with 2+ years of industry experience\n\n - Strong Python engineering skills, including experience building and maintaining production-quality software\n\n - Hands-on experience with LLM APIs (e.g., Claude, GPT) and agentic patterns such as tool use, orchestration, and multi-step reasoning\n\n - Familiarity with biomedical or chemical data sources and formats (e.g., PDB, UniProt, ChEMBL, SDF/MOL, FASTA, or similar)\n\n - Comfort with data engineering fundamentals: ETL design, data validation, and working with structured and unstructured data at scale\n\n - Hands-on experience with Python testing frameworks (e.g., pytest fixtures, parametrization)\n\nPREFERRED QUALIFICATIONS\n\n - Experience with agent orchestration frameworks, and with evaluation harnesses for LLM-generated code\n\n - Familiarity with cloud infrastructure and workflow orchestration (e.g., AWS, Docker, Kubernetes)\n\n - Knowledge of multimodal biomedical data—spanning small molecules, proteins, assays, images, ‘omics, and/or clinical records\n\n - Experience with large-scale dataset construction or curation for ML model training\n\n - Knowledge of agent security practices: sandboxing, scoped credentials, prompt injection\n\n - Interest in a longer-term project: a natural language orchestrator that lets drug prosecution team members request inference, fine-tuning, virtual screens, and dataset analysis without writing code using our internal tools\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$110K – $162K • Multiple Ranges","scrapeableCompensationSalarySummary":"$110K - $162K","compensationTiers":[{"id":"c9df3f60-b18c-448a-8bd9-c67d871e32df","tierSummary":"$110K – $138K","title":"Sr Associate Software Engineer","additionalInformation":null,"components":[{"id":"af31d4cb-ce06-4ada-a442-a5acc947c8ae","summary":"$110K – $138K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":110000,"maxValue":138000}]},{"id":"c0e98ead-1a66-4596-a29c-d9bdc0bdd103","tierSummary":"$130K – $162K","title":"Software Engineer I","additionalInformation":null,"components":[{"id":"7974d414-d1f8-4622-a329-7600b1d4490b","summary":"$130K – $162K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":130000,"maxValue":162000}]}],"summaryComponents":[{"minValue":110000,"maxValue":162000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"5044f2a9-6624-4192-a222-ac147a735f69","title":"Senior Associate Scientist I/II, Purification Sciences","department":"Science","team":"Analytical","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-09-09T23:26:11.309+00:00","isListed":true,"isRemote":false,"workplaceType":"OnSite","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/5044f2a9-6624-4192-a222-ac147a735f69","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/5044f2a9-6624-4192-a222-ac147a735f69/application","descriptionHtml":"JOB SUMMARY
We are seeking a motivated and hands-on Senior Associate Scientist I/II, Purification Sciences to support small-molecule drug discovery. This individual will perform chromatography-based purification, with a focus on preparative LC and preparative SFC, supporting medicinal chemistry and high-throughput chemistry efforts.
The ideal candidate will have practical laboratory experience with chromatographic purification and a strong interest in developing expertise in separation science, instrumentation, and high-throughput purification workflows. Experience with instrument maintenance and troubleshooting is highly desirable. This position will be based in our San Diego Headquarters.
KEY RESPONSIBILITIES
Perform routine and moderately complex small-molecule purification using preparative LC and SFC, supporting medicinal chemistry and high-throughput chemistry workflows.
Develop and optimize purification methods, including column/mobile-phase selection, gradients, sample loading, and fraction collection.
Operate prep LC, prep SFC, analytical LC, and LC/MS systems and perform analytical QC of purified compounds.
Perform routine instrument maintenance and troubleshoot common chromatography, fluidics, hardware, and software issues.
Monitor instrument performance and proactively identify issues to maintain reliable laboratory operations and minimize downtime.
Support high-throughput and automated purification workflows, including sample submission, purification, fraction handling, compound recovery, and data reporting.
Work closely with medicinal chemists and other scientists to prioritize samples and deliver purified compounds with appropriate purity, recovery, and turnaround time.
Support evaluation and implementation of new purification methods, columns, instrumentation, and workflow improvements.
Maintain accurate experimental and instrument documentation and contribute to laboratory best practices.
QUALIFICATIONS
B.S. or M.S. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 3+ years of experience
Relevant hands-on laboratory experience in chromatography and small-molecule purification; level will be determined based on experience and demonstrated technical capabilities.
Working knowledge of chromatographic separation principles and method optimization.
Strong attention to detail, problem-solving skills, and ability to work effectively in a fast-paced, collaborative research environment.
PREFERRED QUALIFICATIONS
Experience with preparative LC and/or preparative SFC is strongly preferred; SFC experience is highly desirable.
Experience operating and troubleshooting chromatography instrumentation is strongly preferred.
Experience with LC/MS-based characterization and purity assessment is desirable.
Experience with automated or high-throughput laboratory workflows is desirable.
Experience with Agilent, Shimadzu, SCIEX, or comparable platforms is a plus.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking a motivated and hands-on Senior Associate Scientist I/II, Purification Sciences to support small-molecule drug discovery. This individual will perform chromatography-based purification, with a focus on preparative LC and preparative SFC, supporting medicinal chemistry and high-throughput chemistry efforts.\n\nThe ideal candidate will have practical laboratory experience with chromatographic purification and a strong interest in developing expertise in separation science, instrumentation, and high-throughput purification workflows. Experience with instrument maintenance and troubleshooting is highly desirable. This position will be based in our San Diego Headquarters.\n\n\n\nKEY RESPONSIBILITIES\n\n - Perform routine and moderately complex small-molecule purification using preparative LC and SFC, supporting medicinal chemistry and high-throughput chemistry workflows.\n\n - Develop and optimize purification methods, including column/mobile-phase selection, gradients, sample loading, and fraction collection.\n\n - Operate prep LC, prep SFC, analytical LC, and LC/MS systems and perform analytical QC of purified compounds.\n\n - Perform routine instrument maintenance and troubleshoot common chromatography, fluidics, hardware, and software issues.\n\n - Monitor instrument performance and proactively identify issues to maintain reliable laboratory operations and minimize downtime.\n\n - Support high-throughput and automated purification workflows, including sample submission, purification, fraction handling, compound recovery, and data reporting.\n\n - Work closely with medicinal chemists and other scientists to prioritize samples and deliver purified compounds with appropriate purity, recovery, and turnaround time.\n\n - Support evaluation and implementation of new purification methods, columns, instrumentation, and workflow improvements.\n\n - Maintain accurate experimental and instrument documentation and contribute to laboratory best practices.\n\n\n\nQUALIFICATIONS\n\n - B.S. or M.S. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 3+ years of experience\n\n - Relevant hands-on laboratory experience in chromatography and small-molecule purification; level will be determined based on experience and demonstrated technical capabilities.\n\n - Working knowledge of chromatographic separation principles and method optimization.\n\n - Strong attention to detail, problem-solving skills, and ability to work effectively in a fast-paced, collaborative research environment.\n\nPREFERRED QUALIFICATIONS\n\n - Experience with preparative LC and/or preparative SFC is strongly preferred; SFC experience is highly desirable.\n\n - Experience operating and troubleshooting chromatography instrumentation is strongly preferred.\n\n - Experience with LC/MS-based characterization and purity assessment is desirable.\n\n - Experience with automated or high-throughput laboratory workflows is desirable.\n\n - Experience with Agilent, Shimadzu, SCIEX, or comparable platforms is a plus.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$88K – $128K • Multiple Ranges","scrapeableCompensationSalarySummary":"$88K - $128K","compensationTiers":[{"id":"1882e5ee-f9c5-40bd-864e-95e2ffec7fe6","tierSummary":"$88K – $110K","title":"Sr Associate Scientist I","additionalInformation":null,"components":[{"id":"a1ac644c-3833-40bc-bdbb-3d05884164eb","summary":"$88K – $110K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":88000,"maxValue":110000}]},{"id":"c149467d-923e-4249-a161-16a2aca1f70b","tierSummary":"$102K – $128K","title":"Sr Associate Scientist II","additionalInformation":null,"components":[{"id":"13fe38f2-5995-46b8-8f34-b43968cc8fb3","summary":"$102K – $128K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":102000,"maxValue":128000}]}],"summaryComponents":[{"minValue":88000,"maxValue":128000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"35fa46c2-1cd5-4222-88f5-987e7bf26db7","title":"Research Scientist I/II, Purification Sciences","department":"Science","team":"Analytical","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-09-09T23:29:55.506+00:00","isListed":true,"isRemote":false,"workplaceType":"OnSite","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/35fa46c2-1cd5-4222-88f5-987e7bf26db7","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/35fa46c2-1cd5-4222-88f5-987e7bf26db7/application","descriptionHtml":"JOB SUMMARY
We are seeking an experienced and highly motivated Research Scientist, Purification & Analytical Sciences to develop and advance small-molecule purification and high-throughput analytical capabilities within our drug discovery team. This scientist will provide scientific and technical expertise in preparative SFC and LC purification, as well as high-throughput compound QC, supporting medicinal chemistry and high-throughput experimentation (HTE) platform.
A key focus of this role will be SFC-based purification, including method development, optimization, and application to diverse and challenging chemical matter. The ideal candidate will combine strong fundamentals in chromatographic separation science with hands-on expertise in analytical QC, instrument troubleshooting, automation, and high-throughput workflows.
This scientist will work closely with HTE, medicinal chemistry and other discovery teams to rapidly deliver purified, well-characterized compounds and high-quality analytical data, supporting an AI-driven design–make–test–learn drug discovery cycle. This position will be based out of our San Diego Headquarters.
KEY RESPONSIBILITIES
Develop and execute small-molecule purification strategies using preparative SFC and LC, with particular emphasis on SFC method development and optimization.
Independently solve challenging separations through optimization of stationary/mobile phases, selectivity, gradients, sample loading, scale-up, and fraction collection.
Develop and support high-throughput compound QC workflows using LC/MS and related analytical techniques to assess compound identity, purity, and sample quality.
Collaborate with medicinal chemistry and HTE teams to establish fit-for-purpose purification and QC strategies and rapidly deliver high-quality compounds.
Serve as a technical resource for SFC/LC purification, analytical QC, and instrument troubleshooting, including root-cause analysis of chromatography, fluidics, hardware, and software issues.
Provide hands-on support for SFC, LC, and LC/MS platforms, including maintenance, system optimization, and vendor coordination.
Develop and improve automated and high-throughput purification and QC workflows, integrating sample handling, purification, fraction processing, analytical characterization, and data management.
Evaluate and implement new chromatography, analytical, automation, and informatics technologies to expand throughput, capacity, and operational efficiency.
QUALIFICATIONS
Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 0-5 years of relevant experience; or a MS with 7+ years / BS with 9+ years of relevant experience.
Strong hands-on expertise in small-molecule chromatographic purification and method development, preferably in a pharmaceutical, biotechnology, CRO, or drug discovery environment.
Demonstrated expertise in preparative SFC, including method development, optimization, and troubleshooting; preparative LC experience is strongly preferred.
Strong understanding of chromatographic separation science and demonstrated ability to independently solve complex purification problems.
Strong instrument troubleshooting skills, including experience diagnosing chromatography, fluidics, hardware, software, and workflow issues.
Strong understanding of medicinal chemistry and small-molecule drug discovery, with the ability to translate project needs into effective purification and analytical strategies.
Excellent scientific problem-solving, communication, and collaboration skills.
PREFERRED QUALIFICATIONS
Experience with high-throughput LC/MS analysis and compound QC, including purity and identity assessment, is strongly preferred.
Experience with automation, high-throughput workflows, and informatics/data-management systems is highly desirable.
Experience with Agilent, Shimadzu, or comparable analytical and purification platforms is a plus.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are seeking an experienced and highly motivated Research Scientist, Purification & Analytical Sciences to develop and advance small-molecule purification and high-throughput analytical capabilities within our drug discovery team. This scientist will provide scientific and technical expertise in preparative SFC and LC purification, as well as high-throughput compound QC, supporting medicinal chemistry and high-throughput experimentation (HTE) platform.\n\nA key focus of this role will be SFC-based purification, including method development, optimization, and application to diverse and challenging chemical matter. The ideal candidate will combine strong fundamentals in chromatographic separation science with hands-on expertise in analytical QC, instrument troubleshooting, automation, and high-throughput workflows.\n\nThis scientist will work closely with HTE, medicinal chemistry and other discovery teams to rapidly deliver purified, well-characterized compounds and high-quality analytical data, supporting an AI-driven design–make–test–learn drug discovery cycle. This position will be based out of our San Diego Headquarters.\n\n\n\nKEY RESPONSIBILITIES\n\n - Develop and execute small-molecule purification strategies using preparative SFC and LC, with particular emphasis on SFC method development and optimization.\n\n - Independently solve challenging separations through optimization of stationary/mobile phases, selectivity, gradients, sample loading, scale-up, and fraction collection.\n\n - Develop and support high-throughput compound QC workflows using LC/MS and related analytical techniques to assess compound identity, purity, and sample quality.\n\n - Collaborate with medicinal chemistry and HTE teams to establish fit-for-purpose purification and QC strategies and rapidly deliver high-quality compounds.\n\n - Serve as a technical resource for SFC/LC purification, analytical QC, and instrument troubleshooting, including root-cause analysis of chromatography, fluidics, hardware, and software issues.\n\n - Provide hands-on support for SFC, LC, and LC/MS platforms, including maintenance, system optimization, and vendor coordination.\n\n - Develop and improve automated and high-throughput purification and QC workflows, integrating sample handling, purification, fraction processing, analytical characterization, and data management.\n\n - Evaluate and implement new chromatography, analytical, automation, and informatics technologies to expand throughput, capacity, and operational efficiency.\n\n\n\nQUALIFICATIONS\n\n - Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 0-5 years of relevant experience; or a MS with 7+ years / BS with 9+ years of relevant experience.\n\n - Strong hands-on expertise in small-molecule chromatographic purification and method development, preferably in a pharmaceutical, biotechnology, CRO, or drug discovery environment.\n\n - Demonstrated expertise in preparative SFC, including method development, optimization, and troubleshooting; preparative LC experience is strongly preferred.\n\n - Strong understanding of chromatographic separation science and demonstrated ability to independently solve complex purification problems.\n\n - Strong instrument troubleshooting skills, including experience diagnosing chromatography, fluidics, hardware, software, and workflow issues.\n\n - Strong understanding of medicinal chemistry and small-molecule drug discovery, with the ability to translate project needs into effective purification and analytical strategies.\n\n - Excellent scientific problem-solving, communication, and collaboration skills.\n\nPREFERRED QUALIFICATIONS\n\n - Experience with high-throughput LC/MS analysis and compound QC, including purity and identity assessment, is strongly preferred.\n\n - Experience with automation, high-throughput workflows, and informatics/data-management systems is highly desirable.\n\n - Experience with Agilent, Shimadzu, or comparable analytical and purification platforms is a plus.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$113.6K – $156K • Multiple Ranges","scrapeableCompensationSalarySummary":"$113.6K - $156K","compensationTiers":[{"id":"dee31f94-01ab-4380-ab45-96cc7469fab8","tierSummary":"$113.6K – $142K","title":"Research Scientist I","additionalInformation":null,"components":[{"id":"67d52874-31cd-480b-b4d4-1bcc277ef627","summary":"$113.6K – $142K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":113600,"maxValue":142000}]},{"id":"c50a7b4e-8291-4973-a3dc-277eacc1345d","tierSummary":"$124.8K – $156K","title":"Research Scientist II","additionalInformation":null,"components":[{"id":"dbab347b-5857-4ce1-b7d5-b1561b488635","summary":"$124.8K – $156K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":124800,"maxValue":156000}]}],"summaryComponents":[{"minValue":113600,"maxValue":156000,"currencyCode":"USD","interval":"1 YEAR","compensationType":"Salary"}]}},{"id":"fe3cabb2-f946-4279-aa9a-ff953e88330a","title":"Associate Director, Drug Safety","department":"Clinical","team":"Clinical Development","employmentType":"FullTime","location":"Remote - US","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[{"location":"San Diego HQ","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}}}],"publishedAt":"2026-09-16T17:49:09.893+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/fe3cabb2-f946-4279-aa9a-ff953e88330a","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/fe3cabb2-f946-4279-aa9a-ff953e88330a/application","descriptionHtml":"JOB SUMMARY
We are hiring an Associate Director, Drug Safety to join our Safety team at Iambic Therapeutics. Reporting to the Head of Safety, the Associate Director will oversee outsourced pharmacovigilance activities and contribute to regulatory and safety deliverables. The Associate Director will work collaboratively with Quality, Clinical operations, and Clinical development to set up and execute safety processes. A successful candidate will have flexibility in our dynamic and growing organization. The Associate Director will have responsibilities across all phases of development for our oral small-molecule oncology therapies.
The position may be based in our San Diego headquarters or remote.
KEY RESPONSIBILITIES
Case processing and vendor oversight
Provide day-to-day oversight of SAE processing activities performed internally and externally.
Coordinate reconciliation of safety information across clinical databases and business partners.
Monitor vendor performance through compliance trends and review of operational deliverables. Tracking of actions items, issues, corrective actions.
Support implementation, maintenance, and enhancement of safety databases as applicable.
Safety Science Support
Contribute to aggregate safety reports, safety sections of clinical, safety and regulatory documents as requested.
Coordinate safety data deliverables for aggregate reports, regulatory submissions, and health authority requests.
Review individual and aggregate safety data and identify emerging trends.
PV Quality, Compliance & Inspection Readiness
Co-author and maintain controlled documents, Safety Management Plans, Safety Data Exchange Agreements, and other documents needed to ensure inspection readiness.
Support CAPAs, change controls, audits, and regulatory inspections.
QUALIFICATIONS
Bachelor's degree in nursing or pharmacy; advanced degree such as PharmD, MSN, MPH, or equivalent preferred.
At least 10 years of combined experience in pharmacovigilance, drug safety, clinical science, or a related environment with a Bachelor’s degree and 6-8 years with an advanced degree.
Related experience across both safety science/surveillance and pharmacovigilance operations preferred.
Strong understanding of MedDRA and WHODrug dictionaries.
Proficiency in the use of Safety Databases.
Excellent interpersonal skills and professionalism.
Written and verbal proficiency with ability to communicate clinical topics succinctly and clearly.
Ability to train, mentor junior Drug Safety staff, contractors, consultants, and vendor personnel.
Knowledge of applicable global pharmacovigilance regulations and guidance, including FDA, EMA, ICH, GCP, and GVP requirements.
Oncology phase I to III experience preferred.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are hiring an Associate Director, Drug Safety to join our Safety team at Iambic Therapeutics. Reporting to the Head of Safety, the Associate Director will oversee outsourced pharmacovigilance activities and contribute to regulatory and safety deliverables. The Associate Director will work collaboratively with Quality, Clinical operations, and Clinical development to set up and execute safety processes. A successful candidate will have flexibility in our dynamic and growing organization. The Associate Director will have responsibilities across all phases of development for our oral small-molecule oncology therapies.\n\nThe position may be based in our San Diego headquarters or remote.\n\n\n\nKEY RESPONSIBILITIES\n\nCase processing and vendor oversight\n\n - Provide day-to-day oversight of SAE processing activities performed internally and externally.\n\n - Coordinate reconciliation of safety information across clinical databases and business partners.\n\n - Monitor vendor performance through compliance trends and review of operational deliverables. Tracking of actions items, issues, corrective actions.\n\n - Support implementation, maintenance, and enhancement of safety databases as applicable.\n\nSafety Science Support\n\n - Contribute to aggregate safety reports, safety sections of clinical, safety and regulatory documents as requested.\n\n - Coordinate safety data deliverables for aggregate reports, regulatory submissions, and health authority requests.\n\n - Review individual and aggregate safety data and identify emerging trends.\n\nPV Quality, Compliance & Inspection Readiness\n\n - Co-author and maintain controlled documents, Safety Management Plans, Safety Data Exchange Agreements, and other documents needed to ensure inspection readiness.\n\n - Support CAPAs, change controls, audits, and regulatory inspections.\n\n\n\nQUALIFICATIONS\n\n - Bachelor's degree in nursing or pharmacy; advanced degree such as PharmD, MSN, MPH, or equivalent preferred.\n\n - At least 10 years of combined experience in pharmacovigilance, drug safety, clinical science, or a related environment with a Bachelor’s degree and 6-8 years with an advanced degree.\n\n - Related experience across both safety science/surveillance and pharmacovigilance operations preferred.\n\n - Strong understanding of MedDRA and WHODrug dictionaries.\n\n - Proficiency in the use of Safety Databases.\n\n - Excellent interpersonal skills and professionalism.\n\n - Written and verbal proficiency with ability to communicate clinical topics succinctly and clearly.\n\n - Ability to train, mentor junior Drug Safety staff, contractors, consultants, and vendor personnel.\n\n - Knowledge of applicable global pharmacovigilance regulations and guidance, including FDA, EMA, ICH, GCP, and GVP requirements.\n\n - Oncology phase I to III experience preferred.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$164K – $205K","scrapeableCompensationSalarySummary":"$164K - $205K","compensationTiers":[{"id":"83748739-df1f-4d85-8116-00fc01e37476","tierSummary":"$164K – $205K","title":null,"additionalInformation":null,"components":[{"id":"243fe3a1-faeb-438f-87c7-20c6e44b09b0","summary":"$164K – $205K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":164000,"maxValue":205000}]}],"summaryComponents":[{"compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":164000,"maxValue":205000}]}},{"id":"f9141ac3-236e-4e29-bcc4-310d1116197a","title":"Director, Compensation, Benefits and HR Systems","department":"G&A","team":"Human Resources","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-09-10T21:39:04.135+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/f9141ac3-236e-4e29-bcc4-310d1116197a","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/f9141ac3-236e-4e29-bcc4-310d1116197a/application","descriptionHtml":"JOB SUMMARY
We are hiring a Director of Compensation, Benefits and HR Systems to join our growing Human Resources team at Iambic Therapeutic's. Reporting to the Head of HR, this role will lead the design, implementation and ongoing management of Iambic’s compensation, benefits and HR technology platforms. They will ensure our programs are competitive, scalable, compliant, and aligned with Iambic’s talent strategy and business objectives, supporting a rapidly growing biotech company. This role is based at our San Diego Headquarters.
KEY RESPONSIBILITIES
Lead the company’s compensation strategy and programs, including salary structures, job leveling, annual compensation reviews, bonus programs, equity guidelines, promotions, and market benchmarking.
Manage executive, employee and international compensation benchmarking
Oversee employee benefits programs, including health insurance, retirement, leave, wellness, and other benefit offerings; evaluate competitiveness, cost, and employee experience.
Lead annual benefits renewal and open enrollment processes and manage relationships with brokers, consultants, and benefit vendors.
Own HRIS strategy and administration, including PEO exit, ensuring systems, workflows, integrations, reporting, and data are accurate, efficient, and scalable.
Establish and maintain policies, controls, documentation, and governance across compensation, benefits, and HR systems.
Identify opportunities to automate and streamline HR processes and improve the employee and manager experience.
Stay current on market trends, regulatory requirements, and emerging practices in compensation, benefits, and HR technology.
QUALIFICATIONS
Bachelor’s degree in human resources, business administration, finance or related field, Certified Compensation Professional (CCP) preferred.
12+ years of progressive HR experience with significant expertise in compensation, benefits, and/or HRIS, including experience leading total rewards programs.
Strong knowledge of compensation benchmarking, salary structures, incentive compensation, equity programs, and job architecture. International experience a plus
Experience managing U.S. benefits programs and working with brokers, consultants, and vendors.
Demonstrated HRIS expertise, including system implementation, optimization, reporting, and data governance.
Strong analytical skills with the ability to translate complex compensation and workforce data into actionable recommendations.
Experience partnering with senior executives, Finance, Legal, and HR leadership.
Strong project management skills and ability to manage multiple priorities in a fast-paced environment.
Experience with a successful transition off a PEO, standing up in-house payroll, benefits administration, and HR Systems preferred.
Experience in a high-growth, biotechnology, technology, or public-company environment preferred.
ABOUT IAMBIC THERAPEUTICS
Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.
MISSION & CORE VALUES
Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.
PAY AND BENEFITS
We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.
","descriptionPlain":"JOB SUMMARY\n\nWe are hiring a Director of Compensation, Benefits and HR Systems to join our growing Human Resources team at Iambic Therapeutic's. Reporting to the Head of HR, this role will lead the design, implementation and ongoing management of Iambic’s compensation, benefits and HR technology platforms. They will ensure our programs are competitive, scalable, compliant, and aligned with Iambic’s talent strategy and business objectives, supporting a rapidly growing biotech company. This role is based at our San Diego Headquarters.\n\n\n\nKEY RESPONSIBILITIES\n\n - Lead the company’s compensation strategy and programs, including salary structures, job leveling, annual compensation reviews, bonus programs, equity guidelines, promotions, and market benchmarking.\n\n - Manage executive, employee and international compensation benchmarking\n\n - Oversee employee benefits programs, including health insurance, retirement, leave, wellness, and other benefit offerings; evaluate competitiveness, cost, and employee experience.\n\n - Lead annual benefits renewal and open enrollment processes and manage relationships with brokers, consultants, and benefit vendors.\n\n - Own HRIS strategy and administration, including PEO exit, ensuring systems, workflows, integrations, reporting, and data are accurate, efficient, and scalable.\n\n - Establish and maintain policies, controls, documentation, and governance across compensation, benefits, and HR systems.\n\n - Identify opportunities to automate and streamline HR processes and improve the employee and manager experience.\n\n - Stay current on market trends, regulatory requirements, and emerging practices in compensation, benefits, and HR technology.\n\n\n\nQUALIFICATIONS\n\n - Bachelor’s degree in human resources, business administration, finance or related field, Certified Compensation Professional (CCP) preferred.\n\n - 12+ years of progressive HR experience with significant expertise in compensation, benefits, and/or HRIS, including experience leading total rewards programs.\n\n - Strong knowledge of compensation benchmarking, salary structures, incentive compensation, equity programs, and job architecture. International experience a plus\n\n - Experience managing U.S. benefits programs and working with brokers, consultants, and vendors.\n\n - Demonstrated HRIS expertise, including system implementation, optimization, reporting, and data governance.\n\n - Strong analytical skills with the ability to translate complex compensation and workforce data into actionable recommendations.\n\n - Experience partnering with senior executives, Finance, Legal, and HR leadership.\n\n - Strong project management skills and ability to manage multiple priorities in a fast-paced environment.\n\n - Experience with a successful transition off a PEO, standing up in-house payroll, benefits administration, and HR Systems preferred.\n\n - Experience in a high-growth, biotechnology, technology, or public-company environment preferred.\n\n\n\nABOUT IAMBIC THERAPEUTICS\n\nIambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai.\n\nMISSION & CORE VALUES\n\nOur mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.\n\nPAY AND BENEFITS\n\nWe offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.","compensation":{"compensationTierSummary":"$180K – $225K","scrapeableCompensationSalarySummary":"$180K - $225K","compensationTiers":[{"id":"e182f107-40ec-4755-98aa-f20455271d66","tierSummary":"$180K – $225K","title":null,"additionalInformation":null,"components":[{"id":"0c21a4a8-ba37-4528-b4a9-2165cd2acee6","summary":"$180K – $225K","compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":180000,"maxValue":225000}]}],"summaryComponents":[{"compensationType":"Salary","interval":"1 YEAR","currencyCode":"USD","minValue":180000,"maxValue":225000}]}},{"id":"fa8d8422-5e0b-4f37-8900-4f385912c315","title":"Associate Director, Procurement","department":"G&A","team":"Finance","employmentType":"FullTime","location":"San Diego HQ","shouldDisplayCompensationOnJobPostings":true,"secondaryLocations":[],"publishedAt":"2026-09-14T20:52:39.465+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"California","addressCountry":"United States","addressLocality":"San Diego"}},"jobUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/fa8d8422-5e0b-4f37-8900-4f385912c315","applyUrl":"https://jobs.ashbyhq.com/iambic-therapeutics/fa8d8422-5e0b-4f37-8900-4f385912c315/application","descriptionHtml":"JOB SUMMARY
We are hiring an Associate Director of Procurement to help build out the Supply Chain and Procurement function at Iambic, a company redefining drug discovery and development by applying industry-leading technology. Reporting to the SVP of Finance, this role will be responsible for leading and scaling the company’s procurement function. The ideal candidate will have a solid background in supply chain and procurement within the biotech or pharmaceutical industry. This role will work closely with the Finance Team as well as across multiple departments to improve the effectiveness and efficiency of the Company’s procurement operations. This position will be based out of our San Diego Headquarters.
RESPONSIBILITIES
Define and execute a company-wide procurement strategy aligned with scientific platform needs and corporate objectives
Build, lead, and mentor a small but high-performing procurement team as the organization scales
Establish procurement as a strategic function, influencing decision-making across the organization
Develop long-term sourcing strategies for critical categories including lab automation and scientific instrumentation, CRO/CDMO and building-block suppliers, reagents and consumables, and procurement/data systems
Establish and manage strategic partnerships with key suppliers, CROs, and service providers
Lead complex negotiations, including master service agreements (MSAs), multi-year contracts, and enterprise-level deals
Develop preferred vendor programs and optimize supplier base for quality, cost, and scalability
Monitor supplier performance through KPIs and drive continuous improvement
Act as a key advisor to leadership on external market dynamics, supplier innovation, and make-vs-buy decisions
Lead the transition and implementation of a new procurement/ERP platform (e.g., Coupa), including data migration, process redesign, and change management across the organization
QUALIFICATIONS
Bachelor’s degree in Supply Chain Management, Business Administration, Life Sciences, or related field; MBA or advanced degree strongly preferred
8+ years of progressive procurement/supply chain experience, including leadership roles
Significant experience in biotech, pharma, or life sciences, ideally within a platform-based or R&D-driven organization
Proven track record of building and scaling procurement functions in high-growth environments
Deep expertise in strategic sourcing, category management, and supplier relationship management
Demonstrated success negotiating MSAs, statements of work, and multi-year service agreements with meaningful commercial impact
Experience with ERP and procurement systems (e.g., NetSuite, Coupa) and data-driven decision-making
Experience leading an ERP or procurement platform implementation or migration (e.g., Coupa) strongly preferred
Experience managing or mentoring existing procurement staff through periods of organizational change