{"jobs":[{"id":"3f53a8d2-16fd-4e28-b5e9-fb398128b2d0","title":"National Account Director - West Region","department":"Commercial","team":"Market Access","employmentType":"FullTime","location":"United States","secondaryLocations":[],"publishedAt":"2026-08-11T20:05:06.390+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressCountry":"United States"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/3f53a8d2-16fd-4e28-b5e9-fb398128b2d0","applyUrl":"https://jobs.ashbyhq.com/xenon/3f53a8d2-16fd-4e28-b5e9-fb398128b2d0/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

The National Account Director - West Region, will play a critical leadership role in shaping and executing our U.S. market access strategy with national and large regional commercial payers in preparation for our first launch of Azetukalner in epilepsy. This is a critical, field-based role responsible for building relationships with targeted customers, communicating our value proposition and securing favorable access to minimize hurdles for the patients we serve. We are seeking individuals that are strategic thinkers who thrive in a fast-paced, startup environment, and can contribute across the organization for success.

This position reports to the Senior Director, Payer Accounts, and will be fully remote. This person will be responsible for the West region. The level of the position will be commensurate with the candidate’s education and industry experience.

RESPONSIBILITIES:

Account Expertise & Knowledge

Securing Coverage & Access

Collaboration and Communication

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\n\n\nAbout the Role:\n\nThe National Account Director - West Region, will play a critical leadership role in shaping and executing our U.S. market access strategy with national and large regional commercial payers in preparation for our first launch of Azetukalner in epilepsy. This is a critical, field-based role responsible for building relationships with targeted customers, communicating our value proposition and securing favorable access to minimize hurdles for the patients we serve. We are seeking individuals that are strategic thinkers who thrive in a fast-paced, startup environment, and can contribute across the organization for success.\n\n\n\nThis position reports to the Senior Director, Payer Accounts, and will be fully remote. This person will be responsible for the West region. The level of the position will be commensurate with the candidate’s education and industry experience.\n\n\n\nRESPONSIBILITIES:\n\n - Ensure Xenon’s products are quickly reviewed post approval to ensure rapid formulary adoption enabling patient access that is equal to branded products in relative categories Xenon competes in:\n\n\n\nAccount Expertise & Knowledge\n\n - Establish and maintain multiple touch points at strategic payer accounts, including senior executives, to communicate the Xenon payer value story\n\n - Navigate payer organizations to build long-term relationships with key decision makers and potential influencers paving the way for the pipeline of innovative products from Xenon\n\n - Have complete understanding of the complex payer organizations and different wholly owned subsidiaries who may have services and programs that impact the Epilepsy class. Monitor to assess opportunities for partnerships long term\n\n - Prioritize top accounts using data and personal intelligence\n\n\n\nSecuring Coverage & Access\n\n - Secure access and coverage rapidly for all Xenon products that is at parity with key competitors in respective classes\n\n - Develop strategic business plans by account\n\n - Secure appropriate coverage and formulary positioning in alignment with Commercial goals working collaboratively with Medical Affairs and Value and Access to ensure the value proposition and HEOR data is appropriately communicated to target audiences\n\n - Evaluate contracting opportunities that are consistent with Xenon’s goals. Lead the contract process from initiation to negotiation/completion. Manage ongoing contracts with quarterly business reviews and evaluate ROI\n\n\n\nCollaboration and Communication\n\n - Review data (sales trends, competitive landscape by local market) to identify pull-through opportunities. Work with regional sales directors and sales representatives to address access challenges and maximize success by executing aligned pull-through plans.\n\n - Assist in field training on access and reimbursement\n\n - Deliver payer insights back to market access, medical affairs, and patient services as appropriate.\n\n - Represent Xenon at Key Industry Conferences (e.g., AMCP, Asembia, PCMA)\n\n - Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans\n\n - Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies\n\n - Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n - Some international travel may be required\n\n - Other duties as assigned\n \n \n\nQUALIFICATIONS:\n\n - Minimum of a bachelor's degree required; advanced degree a plus\n\n - Minimum of 10-12 years of market access experience, in biotech pharmaceuticals with at least 5 years calling on national accounts\n\n - In-depth knowledge of payer/PBM economics: understanding key issues and how these shift given changing US healthcare landscape\n\n - Clear understanding of analytics: ability to apply analytical insight to drive account performance and ability to “ask the right questions” of analytical resources\n \n \n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"2b4b633f-bd94-4ebb-a250-5fdf78025943","title":"Senior Director, US Patient Marketing","department":"Commercial","team":"Marketing","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-03-25T13:50:54.005+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/2b4b633f-bd94-4ebb-a250-5fdf78025943","applyUrl":"https://jobs.ashbyhq.com/xenon/2b4b633f-bd94-4ebb-a250-5fdf78025943/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking an experienced Senior Director, US Patient Marketing to lead the development and execution of a comprehensive, patient‑centered marketing strategy in support of Xenon’s first commercial launch and future growth.

This role will be a senior member of the US Marketing organization and will be accountable for shaping the U.S. patient and caregiver brand strategy, ensuring a seamless, compliant, and impactful patient experience from disease awareness through long‑term treatment engagement.

The Senior Director will build and lead a high‑performing Patient Marketing team and partner closely with Patient Services, Advocacy, Medical Affairs, Market Access, Legal, Regulatory, and Commercial leadership to ensure alignment, execution excellence, and meaningful impact for patients and caregivers.

This position reports to the Vice President, Marketing and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

Patient & Caregiver Strategy

Launch Planning & Execution

Integrated Patient Engagement Ecosystem

Advocacy & Patient Voice

Cross‑Functional Leadership

Agency, Budget & Vendor Management

Team Leadership & Capability Building

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking an experienced Senior Director, US Patient Marketing to lead the development and execution of a comprehensive, patient‑centered marketing strategy in support of Xenon’s first commercial launch and future growth.\n\nThis role will be a senior member of the US Marketing organization and will be accountable for shaping the U.S. patient and caregiver brand strategy, ensuring a seamless, compliant, and impactful patient experience from disease awareness through long‑term treatment engagement.\n\nThe Senior Director will build and lead a high‑performing Patient Marketing team and partner closely with Patient Services, Advocacy, Medical Affairs, Market Access, Legal, Regulatory, and Commercial leadership to ensure alignment, execution excellence, and meaningful impact for patients and caregivers.\n\nThis position reports to the Vice President, Marketing and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\nPatient & Caregiver Strategy\n\n - Lead the development of a comprehensive U.S. patient and caregiver marketing strategy, including unbranded disease education and branded patient engagement initiatives\n\n - Define patient and caregiver value propositions, journey frameworks, and engagement strategies across the continuum of care\n\n - Ensure a deeply patient‑centric approach that reflects real‑world needs, barriers, and lived experiences\n\nLaunch Planning & Execution\n\n - Serve as the Patient Marketing lead for U.S. launch readiness, ensuring patient programs, materials, and services are launch‑ready\n\n - Partner with cross‑functional launch teams to integrate patient marketing into overall brand and launch strategy\n\n - Develop phased launch plans that evolve from pre‑launch education through post‑launch activation and adherence support\n\nIntegrated Patient Engagement Ecosystem\n\n - Lead development of an integrated, compliant patient engagement ecosystem, including digital, non‑personal, and field‑enabled channels\n\n - Oversee creation of patient‑focused content, tools, and resources that support education, onboarding, activation, and persistence\n\n - Leverage data, analytics, and insights to optimize patient engagement and personalize experiences over time\n\nAdvocacy & Patient Voice\n\n - Partner closely with Patient Advocacy to ensure patient voices and perspectives are embedded across strategy, content, and programs\n\n - Support development and execution of patient advisory boards and community engagement initiatives\n\n - Ensure alignment with advocacy partners while maintaining compliance and transparency\n\nCross‑Functional Leadership\n\n - Collaborate with Medical Affairs, Patient Services, Market Access, Legal, Regulatory, Compliance, and Commercial Operations to deliver a cohesive patient experience\n\n - Partner with Insights & Analytics to define success metrics, monitor performance, and continuously improve patient programs\n\n - Act as the patient marketing subject‑matter expert to senior leadership and cross‑functional stakeholders\n\nAgency, Budget & Vendor Management\n\n - Select, manage, and lead external agency partners and vendors\n\n - Own patient marketing budgets, ensuring effective resource allocation and ROI\n\n - Ensure all activities adhere to regulatory, legal, and promotional review requirements\n\nTeam Leadership & Capability Building\n\n - Build, mentor, and lead a high‑performing Patient Marketing team\n\n - Foster a culture of collaboration, accountability, innovation, and patient‑first thinking\n\n - Develop patient marketing capabilities that can scale with portfolio and organizational growth\n\n - Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans\n\n - Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies\n\n - Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n - Other duties as assigned\n\nQUALIFICATIONS:\n\n - Minimum undergraduate degree, advanced degree preferred. 12+ years of relevant experience or combination of degrees and experience.\n\n - US large category launch and epilepsy/neurology experience highly preferred\n\n - Proven experience leading patient marketing strategy\n\n - Demonstrated success building and leading high‑impact teams in a matrixed environment; and collaborating and influencing cross-functionally\n\n - Deep understanding of regulatory and compliance requirements related to patient marketing\n\n - Strong strategic thinking, communication, and executive presence; outstanding project and budget management skills and track record for managing multiple vendors,\n\n - Ability to travel up to ~25%\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"97652649-abce-487f-a7f3-93ad207c9c37","title":"Vice President, Sales","department":"Commercial","team":"Sales","employmentType":"FullTime","location":"United States","secondaryLocations":[],"publishedAt":"2026-08-14T13:25:18.895+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressCountry":"United States"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/97652649-abce-487f-a7f3-93ad207c9c37","applyUrl":"https://jobs.ashbyhq.com/xenon/97652649-abce-487f-a7f3-93ad207c9c37/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Vice President, Sales to join our team. The Vice President, Sales will lead the design, build, and execution of Xenon’s U.S. commercial sales organization as the company evolves from a clinical stage biopharmaceutical company into a fully integrated commercial enterprise. This individual will play a critical role in shaping national sales strategy, building a high performing field organization, and driving commercial execution across specialty neurology and CNS markets.

As a core member of the commercial leadership team, the Vice President, Sales will define the field structure, hire and develop sales leadership and frontline talent, and establish the systems, processes, and performance expectations needed to scale effectively. This individual will partner closely with Marketing, Market Access, Medical Affairs, Commercial Operations, Legal, and Compliance to ensure a coordinated, compliant, and high impact go to market strategy.

Success in this role will require strong specialty sales leadership, experience building and scaling teams in growth stage environments, and the ability to translate strategy into focused field execution in a competitive and evolving CNS landscape.

This position reports to the Senior Vice President, Sales & Marketing and will be fully remote.

RESPONSIBILITIES:

· Develop and execute the U.S. sales strategy in alignment with corporate and commercial objectives

· Partner with executive leadership to shape commercial vision and growth strategy

· Lead sales launch readiness planning, including field deployment strategy, targeting philosophy, training input, incentive plan partnership, and execution readiness

· Define the field structure, talent profile, and leadership expectations for the sales organization

· Build, hire, lead, and develop a high performing national sales organization, including Regional Directors and field representatives

· Establish clear performance metrics, sales goals, and accountability frameworks across the organization

· Establish the culture, leadership standards, and talent bar for the sales organization to support long term performance and scalability

· Partner with Commercial Operations to implement dashboards, CRM tools, reporting, and other infrastructure to enhance field effectiveness and visibility

· Drive execution excellence through coaching, training, performance management, and strong field leadership

· Collaborate closely with Marketing, Market Access, Medical Affairs, and other cross functional partners to ensure a coordinated go to market approach

· Develop strong relationships with priority customers, thought leaders, and other key stakeholders across the treatment landscape

· Partner with Market Access and related functions to support pull through strategies across specialty pharmacies, health systems, and integrated delivery networks

· Align with Regulatory, Legal, and Compliance to ensure all sales activities are conducted in a compliant and patient focused manner

· Use data, analytics, and field insights to inform targeting, resource allocation, and ongoing sales optimization

· Monitor market dynamics, customer insights, and competitive activity to refine strategy and improve execution

· Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans

· Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies

· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any

· Some international travel may be required

· Other duties as assigned

QUALIFICATIONS:

· Bachelor’s degree required

· 15+ years of pharmaceutical/biotech sales experience, including 5+ years in senior leadership roles

· Proven track record of successful product launches, ideally in specialty or rare disease markets

· Experience in neurology, epilepsy, or CNS therapeutic areas strongly preferred

· Proven ability to hire, assess, and develop high performing sales leaders and field teams in a growth stage environment

· Experience leading second line sales leaders and scaling national field organizations

· Experience leading sales planning and field execution for a first launch or early commercial stage biopharma company strongly preferred

· Deep understanding of the U.S. healthcare ecosystem, including payer dynamics and specialty distribution

· Strong experience with KOL engagement and specialty customer strategy in complex therapeutic markets

· Demonstrated ability to build sales infrastructure, performance frameworks, and operating discipline in emerging or evolving commercial organizations

· Strong executive presence, communication, and cross functional leadership skills, with the ability to influence strategy and execution across departments

· Demonstrated success operating effectively in fast paced, growth stage environments where agility, judgment, and hands on leadership are essential

· Travel approximately 35%

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Vice President, Sales to join our team. The Vice President, Sales will lead the design, build, and execution of Xenon’s U.S. commercial sales organization as the company evolves from a clinical stage biopharmaceutical company into a fully integrated commercial enterprise. This individual will play a critical role in shaping national sales strategy, building a high performing field organization, and driving commercial execution across specialty neurology and CNS markets.\n\nAs a core member of the commercial leadership team, the Vice President, Sales will define the field structure, hire and develop sales leadership and frontline talent, and establish the systems, processes, and performance expectations needed to scale effectively. This individual will partner closely with Marketing, Market Access, Medical Affairs, Commercial Operations, Legal, and Compliance to ensure a coordinated, compliant, and high impact go to market strategy.\n\nSuccess in this role will require strong specialty sales leadership, experience building and scaling teams in growth stage environments, and the ability to translate strategy into focused field execution in a competitive and evolving CNS landscape.\n\nThis position reports to the Senior Vice President, Sales & Marketing and will be fully remote.\n\nRESPONSIBILITIES:\n\n· Develop and execute the U.S. sales strategy in alignment with corporate and commercial objectives\n\n· Partner with executive leadership to shape commercial vision and growth strategy\n\n· Lead sales launch readiness planning, including field deployment strategy, targeting philosophy, training input, incentive plan partnership, and execution readiness\n\n· Define the field structure, talent profile, and leadership expectations for the sales organization\n\n· Build, hire, lead, and develop a high performing national sales organization, including Regional Directors and field representatives\n\n· Establish clear performance metrics, sales goals, and accountability frameworks across the organization\n\n· Establish the culture, leadership standards, and talent bar for the sales organization to support long term performance and scalability\n\n· Partner with Commercial Operations to implement dashboards, CRM tools, reporting, and other infrastructure to enhance field effectiveness and visibility\n\n· Drive execution excellence through coaching, training, performance management, and strong field leadership\n\n· Collaborate closely with Marketing, Market Access, Medical Affairs, and other cross functional partners to ensure a coordinated go to market approach\n\n· Develop strong relationships with priority customers, thought leaders, and other key stakeholders across the treatment landscape\n\n· Partner with Market Access and related functions to support pull through strategies across specialty pharmacies, health systems, and integrated delivery networks\n\n· Align with Regulatory, Legal, and Compliance to ensure all sales activities are conducted in a compliant and patient focused manner\n\n· Use data, analytics, and field insights to inform targeting, resource allocation, and ongoing sales optimization\n\n· Monitor market dynamics, customer insights, and competitive activity to refine strategy and improve execution\n\n· Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans\n\n· Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies\n\n· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n· Some international travel may be required\n\n· Other duties as assigned\n\nQUALIFICATIONS:\n\n· Bachelor’s degree required\n\n· 15+ years of pharmaceutical/biotech sales experience, including 5+ years in senior leadership roles\n\n· Proven track record of successful product launches, ideally in specialty or rare disease markets\n\n· Experience in neurology, epilepsy, or CNS therapeutic areas strongly preferred\n\n· Proven ability to hire, assess, and develop high performing sales leaders and field teams in a growth stage environment\n\n· Experience leading second line sales leaders and scaling national field organizations\n\n· Experience leading sales planning and field execution for a first launch or early commercial stage biopharma company strongly preferred\n\n· Deep understanding of the U.S. healthcare ecosystem, including payer dynamics and specialty distribution\n\n· Strong experience with KOL engagement and specialty customer strategy in complex therapeutic markets\n\n· Demonstrated ability to build sales infrastructure, performance frameworks, and operating discipline in emerging or evolving commercial organizations\n\n· Strong executive presence, communication, and cross functional leadership skills, with the ability to influence strategy and execution across departments\n\n· Demonstrated success operating effectively in fast paced, growth stage environments where agility, judgment, and hands on leadership are essential\n\n· Travel approximately 35%\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"2e74f392-3974-488b-a726-406f15e48f6a","title":"Senior Manager, Regulatory Affairs, Operations","department":"Clinical Development","team":"Regulatory","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-04-16T18:17:05.120+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/2e74f392-3974-488b-a726-406f15e48f6a","applyUrl":"https://jobs.ashbyhq.com/xenon/2e74f392-3974-488b-a726-406f15e48f6a/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

The Senior Manager, Regulatory Affairs Operations is instrumental in supporting global regulatory submissions across Xenon’s development portfolio. This role is responsible for submission operations, publishing strategy, and lifecycle management, partnering closely with Regulatory Program Leads and cross-functional teams to ensure timely, compliant global filings. The position operates in a fast‑paced environment and requires strong operational judgment, clear written and verbal communication, and effective vendor oversight.

The ideal candidate should demonstrate deep expertise in RIM systems, and a solid understanding of FDA and EMA regulatory requirements. Additionally, they should possess experience managing the lifecycle of regulatory submissions, including INDs, international clinical trial applications (CTAs), and marketing applications in eCTD format.

This position reports to the Director, Regulatory Affairs, Operations, and is based out of Xenon USA’s Needham, MA, USA office. We will consider other jurisdictions for exceptional candidates. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nThe Senior Manager, Regulatory Affairs Operations is instrumental in supporting global regulatory submissions across Xenon’s development portfolio. This role is responsible for submission operations, publishing strategy, and lifecycle management, partnering closely with Regulatory Program Leads and cross-functional teams to ensure timely, compliant global filings. The position operates in a fast‑paced environment and requires strong operational judgment, clear written and verbal communication, and effective vendor oversight.\n\nThe ideal candidate should demonstrate deep expertise in RIM systems, and a solid understanding of FDA and EMA regulatory requirements. Additionally, they should possess experience managing the lifecycle of regulatory submissions, including INDs, international clinical trial applications (CTAs), and marketing applications in eCTD format.\n\nThis position reports to the Director, Regulatory Affairs, Operations, and is based out of Xenon USA’s Needham, MA, USA office. We will consider other jurisdictions for exceptional candidates. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.\n\nRESPONSIBILITIES:\n\n - Regulatory Information Management (RIM) system expertise:\n \n - Submission/registration management\n \n - eCTD & publishing integration\n \n - Lifecycle management\n \n - Metadata & data governance\n \n - Workflow and process configuration\n\n - Maintain processes for regulatory submission document formatting, working with external publishing vendors, and transmittal to regulatory agencies.\n\n - Manage contractual relationships and workstreams with external publishing vendors for building submissions in the eCTD structure and filing the output via the Electronic Submissions Gateway (ESG).\n\n - Serve as the unblinded regulatory person for the sign-off (Covering Letter/FDA form 1571) and manage the submission of expedited safety reports (i.e., SUSARs) to the FDA. In addition, performing periodic review of safety submission trackers for submission compliance with regulatory timeline requirements.\n\n - Support regulatory program leads and project teams in creating timelines for activities related to the preparation and publishing of regulatory submissions.\n\n - Maintain the Xenon regulatory submission calendar and other internal trackers, provide status updates, and ensuring that stakeholders have the most recent versions for their reference.\n\n - Provide advice from an operation’s perspective across all projects on the acceptability of regulatory submission and publishing timelines in regard to coordination of internal and external resources and vendors.\n\n - Contribute to internal process improvements that impact on Regulatory department operational functions.\n\n - Communicate current and emerging publishing and routine reporting regulatory requirements to stakeholder groups within Xenon.\n\n - Advise on and direct the evaluation, selection, and implementation of technology, systems, and tools related to submission planning, publishing, assembly, and archiving.\n\n - Contributes to the development of SOPs, Work Instructions (WIs) and training materials required to support the activities. Consults with other groups to ensure consistency in processes and procedures for documents destined for regulatory submissions. Updates internal processes to ensure compliance with health authority requirements and expectations.\n\n - Develop and maintain document templates (e.g., eCTD content and structure per ICH guidelines) and internal style guides for documents to be submitted in regulatory filings.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n - Some international travel may be required\n\n - Other duties as assigned\n\nQUALIFICATIONS:\n\n - Bachelor’s degree in a scientific discipline with 8+ years of regulatory documentation and operations experience in a pharmaceutical, biotechnology or contract research organization (CRO), including experience in project coordination and document management systems and processes. A combination of degrees and experience will be considered.\n\n - A minimum of 5 years’ management level experience in a pharma or biotech environment.\n\n - Experience with pharmaceutical regulatory submissions (specifically, eCTD) and supporting regulatory filings, such as annual reports, IND/CTA or NDA/MAA.\n\n - Understanding of the drug development process, FDA/EMA regulations and ICH guidance.\n\n - Expert proficiency in MS Word, PowerPoint, Excel, and Adobe Acrobat.\n\n - Hands-on experience in the process of generating, reviewing and formatting documentation for worldwide regulatory submissions.\n\n - Familiarity with eCTD publishing software.\n\n - Understanding of best practices for regulatory filing planning; ability to create and manage an accessible and reliable system for regulatory document retrieval and archiving.\n\n - Demonstrate strong initiative and drive. Must be organized, highly collaborative, and able to problem-solve and anticipate departmental needs.\n\n - Ability to work successfully in cross-functional teams. Strong interpersonal and communication skills.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"66a87f03-02a8-427a-978a-93b0068eb238","title":"Executive Director, Total Rewards","department":"General & Administration","team":"Human Resources","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-05-14T17:14:43.413+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/66a87f03-02a8-427a-978a-93b0068eb238","applyUrl":"https://jobs.ashbyhq.com/xenon/66a87f03-02a8-427a-978a-93b0068eb238/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking an Executive Director, Total Rewards to join our team. The Executive Director, Total Rewards will be a key member of a highly collaborative HR team and will evolve, develop, and manage the execution of total compensation strategies and programs to align with near- and long-term business objectives, our culture and values, and are market competitive to enable Xenon to attract, reward, and retain top talent in the U.S. and Canada.

The Executive Director, Total Rewards will be a strategic thinker who is also highly hands-on and enjoys getting into the details to ensure our programs have well-articulated principles and design, robust end-to-end processes, and flawless execution. The Executive Director, Total Rewards will propose and lead benefits program design in the US and depending on qualifications and experience, Canada. In addition, the successful candidate will have proven leadership ability in a fast-paced, multi-jurisdiction environment and will interact with all levels of internal staff, as well as external advisors and suppliers. This is a hands-on role with plans to grow a team in accordance with business need.

The Executive Director, Total Rewards will work closely with a broad range of internal and external partners, including organization leaders, HR Business Partners (HRBPs), Finance and Legal colleagues and external compensation advisors and suppliers. In collaboration with other key functions, the position will ensure compliance with legal and regulatory requirements in the U.S. and Canada as relates to compensation.

This position reports to the Executive Vice President, Human Resources and will be based out of Vancouver, BC, Canada or Boston, MA, USA in our Needham office. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

· In accordance with Xenon’s total rewards philosophy, and in collaboration with the EVP, HR and external advisors, lead the design, implementation and governance of competitive, integrated total rewards strategies (base, bonus, equity, recognition, benefits) to attract key talent, reward high performance, and support employee retention in Canada and the US

· Lead and manage the base salary program including, but not limited to, budget and forecast (i.e. workforce planning, annual review), job design and matching, salary ranges (i.e. preparation and approval, maintenance, pay transparency, legal compliance), annual and promotion increase guidance, and metrics & analysis; provide guidance and coaching to HRBPs to enable delivery of consistent, expert counsel to organization leaders; work with HR Operations and Finance/Payroll to ensure compensation and promotion related activities are completed accurately and in a timely fashion

· Lead and manage incentive compensation for non-Sales employees; collaborate on program design with Sales Management and Commercial HRBP for Sales employees; ensure incentive compensation plans are aligned with performance expectations; work with program lead for performance management to ensure robust and well-articulated program alignment

· In collaboration with key executive leaders and the Compensation Committee, coordinate the design, evolution and management of equity programs, including stock options, full value share plans, and potentially in future, deferred compensation programs

· Support the Executive Vice President, Human Resources in managing external compensation consultants and developing materials for the Compensation Committee and Board of Directors

· Review and provide input on various compensation governance reports, including, for example, proxy Compensation and Discussion Analysis, collaborating with Finance and Legal as required

· Lead and manage non-financial employee recognition programs in collaboration with HRBPs and HR Operations

· Lead and manage US benefits, including health related and 401(k), from design proposals supported by external advisors and industry benchmarking to contracting to employee communications to governance

· Oversee compensation details to enable accurate forecasting for the Annual Operating Plan and 5-year Plan financial data

· Collaborate with HRBPs in continued evolution of Xenon’s Career Framework, particularly as it relates to compensation philosophy and programs

· Collaborate with the HR systems and data team to review and recommend systems to streamline compensation and other reward programs in accordance with Company and HR systems roadmap

· Manage participation in a variety of compensation surveys in Canada and US

· Collaborate with HRBPs and other key functions, such as Finance, to create communication strategies for total rewards programs to foster employee and candidate understanding and appreciation of Xenon’s total compensation packages.

· Develop strong relationships with leaders and internal partners, based on a high level of collaboration, transparency and agility to inform total rewards programs that align with business objectives

· Maintain an up-to-date knowledge on life sciences compensation trends and governance; drive thought leadership to address current and emerging trends and challenges

· Act as a champion for Xenon’s evolving culture and values

· Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans

· Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies

· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any

· Some international travel may be required

· Other duties as assigned

QUALIFICATIONS:

· At minimum a relevant undergraduate degree, including coursework in math, accounting, finance and/or law; MBA strongly preferred

· 15+ years of experience in progressive compensation/HR management roles in a public, multi-national company life sciences organizations experiencing rapid growth and change; experience in both pre-commercial and commercial companies strongly preferred; ideally experience preparing materials for and interacting with the Board and/or Compensation Committee

· Deep business acumen and understanding of how business strategy in biopharma affects total rewards

· Deep hands-on experience and expertise in data and systems, very strong attention to detail

· Strong analytical and conceptual capability, problem solving, and business planning skills; ability to develop and successfully execute strategies at an organizational level

· Ability to adapt and quickly pivot according to business needs

· Excellent written and oral communication skills, including related to compensation context and employee messaging, to executive and non-executive audiences

· Ability to collaborate effectively and build relationships with key stakeholders

· Impeccable integrity, dependability, and a keen sense of urgency to achieve results

· Ability to execute against multiple high priority projects through exceptional organizational, prioritization and project management skills

· Strong skills in Office software, HR and Finance systems and data

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking an Executive Director, Total Rewards to join our team. The Executive Director, Total Rewards will be a key member of a highly collaborative HR team and will evolve, develop, and manage the execution of total compensation strategies and programs to align with near- and long-term business objectives, our culture and values, and are market competitive to enable Xenon to attract, reward, and retain top talent in the U.S. and Canada.\n\nThe Executive Director, Total Rewards will be a strategic thinker who is also highly hands-on and enjoys getting into the details to ensure our programs have well-articulated principles and design, robust end-to-end processes, and flawless execution. The Executive Director, Total Rewards will propose and lead benefits program design in the US and depending on qualifications and experience, Canada. In addition, the successful candidate will have proven leadership ability in a fast-paced, multi-jurisdiction environment and will interact with all levels of internal staff, as well as external advisors and suppliers. This is a hands-on role with plans to grow a team in accordance with business need.\n\nThe Executive Director, Total Rewards will work closely with a broad range of internal and external partners, including organization leaders, HR Business Partners (HRBPs), Finance and Legal colleagues and external compensation advisors and suppliers. In collaboration with other key functions, the position will ensure compliance with legal and regulatory requirements in the U.S. and Canada as relates to compensation.\n\nThis position reports to the Executive Vice President, Human Resources and will be based out of Vancouver, BC, Canada or Boston, MA, USA in our Needham office. Hybrid positions require a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\n· In accordance with Xenon’s total rewards philosophy, and in collaboration with the EVP, HR and external advisors, lead the design, implementation and governance of competitive, integrated total rewards strategies (base, bonus, equity, recognition, benefits) to attract key talent, reward high performance, and support employee retention in Canada and the US\n\n· Lead and manage the base salary program including, but not limited to, budget and forecast (i.e. workforce planning, annual review), job design and matching, salary ranges (i.e. preparation and approval, maintenance, pay transparency, legal compliance), annual and promotion increase guidance, and metrics & analysis; provide guidance and coaching to HRBPs to enable delivery of consistent, expert counsel to organization leaders; work with HR Operations and Finance/Payroll to ensure compensation and promotion related activities are completed accurately and in a timely fashion\n\n· Lead and manage incentive compensation for non-Sales employees; collaborate on program design with Sales Management and Commercial HRBP for Sales employees; ensure incentive compensation plans are aligned with performance expectations; work with program lead for performance management to ensure robust and well-articulated program alignment\n\n· In collaboration with key executive leaders and the Compensation Committee, coordinate the design, evolution and management of equity programs, including stock options, full value share plans, and potentially in future, deferred compensation programs\n\n· Support the Executive Vice President, Human Resources in managing external compensation consultants and developing materials for the Compensation Committee and Board of Directors\n\n· Review and provide input on various compensation governance reports, including, for example, proxy Compensation and Discussion Analysis, collaborating with Finance and Legal as required\n\n· Lead and manage non-financial employee recognition programs in collaboration with HRBPs and HR Operations\n\n· Lead and manage US benefits, including health related and 401(k), from design proposals supported by external advisors and industry benchmarking to contracting to employee communications to governance\n\n· Oversee compensation details to enable accurate forecasting for the Annual Operating Plan and 5-year Plan financial data\n\n· Collaborate with HRBPs in continued evolution of Xenon’s Career Framework, particularly as it relates to compensation philosophy and programs\n\n· Collaborate with the HR systems and data team to review and recommend systems to streamline compensation and other reward programs in accordance with Company and HR systems roadmap\n\n· Manage participation in a variety of compensation surveys in Canada and US\n\n· Collaborate with HRBPs and other key functions, such as Finance, to create communication strategies for total rewards programs to foster employee and candidate understanding and appreciation of Xenon’s total compensation packages.\n\n· Develop strong relationships with leaders and internal partners, based on a high level of collaboration, transparency and agility to inform total rewards programs that align with business objectives\n\n· Maintain an up-to-date knowledge on life sciences compensation trends and governance; drive thought leadership to address current and emerging trends and challenges\n\n· Act as a champion for Xenon’s evolving culture and values\n\n· Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans\n\n· Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies\n\n· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n· Some international travel may be required\n\n· Other duties as assigned\n\nQUALIFICATIONS:\n\n· At minimum a relevant undergraduate degree, including coursework in math, accounting, finance and/or law; MBA strongly preferred\n\n· 15+ years of experience in progressive compensation/HR management roles in a public, multi-national company life sciences organizations experiencing rapid growth and change; experience in both pre-commercial and commercial companies strongly preferred; ideally experience preparing materials for and interacting with the Board and/or Compensation Committee\n\n· Deep business acumen and understanding of how business strategy in biopharma affects total rewards\n\n· Deep hands-on experience and expertise in data and systems, very strong attention to detail\n\n· Strong analytical and conceptual capability, problem solving, and business planning skills; ability to develop and successfully execute strategies at an organizational level\n\n· Ability to adapt and quickly pivot according to business needs\n\n· Excellent written and oral communication skills, including related to compensation context and employee messaging, to executive and non-executive audiences\n\n· Ability to collaborate effectively and build relationships with key stakeholders\n\n· Impeccable integrity, dependability, and a keen sense of urgency to achieve results\n\n· Ability to execute against multiple high priority projects through exceptional organizational, prioritization and project management skills\n\n· Strong skills in Office software, HR and Finance systems and data\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"68cc89da-4ae2-4293-86f9-f681f63ba1ce","title":"Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial)","department":"R&D Operations","team":"CMC Drug Product","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-08-13T18:18:35.573+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/68cc89da-4ae2-4293-86f9-f681f63ba1ce","applyUrl":"https://jobs.ashbyhq.com/xenon/68cc89da-4ae2-4293-86f9-f681f63ba1ce/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial) to join our team. The Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial) manages and oversees the late phase process development, validation and commercial manufacturing of cGMP drug products for deployment in late-stage clinical trials and commercial distribution. The Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial) will be a key member of a highly collaborative internal CMC team, primarily managing drug product process validation, launch and commercial manufacturing through CDMOs and CROs.

This position reports to the Executive Director, CMC, Drug Product and will be based out of our Boston, MA, USA in our Needham office or in our Burnaby, BC, Canada office. We will consider other jurisdictions for exceptional candidates. This role is a hybrid position; hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week. The level of the position will be commensurate with the candidate’s education and industry experience.

RESPONSIBILITIES:

· Lead teams in late-stage process development and scale up, process validation (PPQ) and commercial manufacturing of small molecule drug products.

· Oversee late phase development and manufacturing processes, ensuring compliance with quality and regulatory standards.

· Manage development activities related to late-stage process development and scale up, FMEA analysis, process validation (PPQ) and preparation for commercial launch of small molecules drug products at partner CDMOs and CMO.

· Manage on going commercial manufacturing and primary packaging of approved small molecule drug products by working with supply chain, quality and regulatory groups. Serve as CMC SME of commercial drug product supply.

· Manage the selection of late-stage and commercial CDMOs while considering capabilities, capacities, redundancy and quality.

· Provide input for drug product stability programs and help select appropriate packaging for clinical development and commercial use.

· Evaluate, recommend, and manage qualified CDMOs for manufacturing drug products for late-stage clinical trials, scale-up, registration, validation and commercial use. Collaborate with Quality Assurance to manage audits and inspections of CDMOs and on manufacturing investigations.

· Author and review core CMC documents/modules and other submissions and responses to FDA and other Competent Authorities, ensuring strategic oversight and consistency for regulatory interactions, including IND/NDA/MAA/IMPD filings and periodic updates.

· Stay informed on pharmaceutical development and manufacturing industry science, regulatory guidelines and competitive trends to provide informed recommendations.

· Develop and propose objectives in alignment with overall company strategies and plans.

· Collaborate with development and commercial partnerships, including ex-US collaborations, to ensure global alignment and integration of strategies.

· Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies.

· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

· Some domestic and international travel will be required.

· Other duties as assigned.

QUALIFICATIONS:

· PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, Pharmaceutics, or a related discipline with at least 10 years of relevant management experience in a pharma or biotech environment. Candidates with an MSc and relevant experience may also be considered.

· Extensive experience in managing late-stage drug product manufacturing and commercialization activities (registration, process scale up, validation and launch), including oversight of external Contract Manufacturing Organizations (CMOs).

· Experience in developing formulations of small molecule solid oral and parenteral dosage forms is a plus.

· Strong background in drug product manufacturing sciences with experience with multiple solid oral manufacturing approaches such as capsules, tablets, spray drying, granulation, blending, bottling and blistering.

· Demonstrated success in transitioning development assets to commercial products and ongoing support of commercial manufacturing.

· Experience contributing to and developing CMC sections in US and ex-US regulatory filings.

· In-depth knowledge of cGMP regulations, guidance, principles, and best practices related to drug product development and manufacture.

· Proficiency in Failure Modes Effect Analysis (FMEA) and establishment of Critical Process Parameters (CPPs).

· Experience with CDMO selection, management, contracting, and issue resolution.

· Excellent oral and written communication, leadership, and interpersonal skills, with the ability to build credibility and trust both inside and outside the company.

· Proven ability to build and develop high-performing teams, with strong delegation and conflict resolution skills.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial) to join our team. The Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial) manages and oversees the late phase process development, validation and commercial manufacturing of cGMP drug products for deployment in late-stage clinical trials and commercial distribution. The Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial) will be a key member of a highly collaborative internal CMC team, primarily managing drug product process validation, launch and commercial manufacturing through CDMOs and CROs.\n\nThis position reports to the Executive Director, CMC, Drug Product and will be based out of our Boston, MA, USA in our Needham office or in our Burnaby, BC, Canada office. We will consider other jurisdictions for exceptional candidates. This role is a hybrid position; hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week. The level of the position will be commensurate with the candidate’s education and industry experience.\n\nRESPONSIBILITIES:\n\n· Lead teams in late-stage process development and scale up, process validation (PPQ) and commercial manufacturing of small molecule drug products.\n\n· Oversee late phase development and manufacturing processes, ensuring compliance with quality and regulatory standards.\n\n· Manage development activities related to late-stage process development and scale up, FMEA analysis, process validation (PPQ) and preparation for commercial launch of small molecules drug products at partner CDMOs and CMO.\n\n· Manage on going commercial manufacturing and primary packaging of approved small molecule drug products by working with supply chain, quality and regulatory groups. Serve as CMC SME of commercial drug product supply.\n\n· Manage the selection of late-stage and commercial CDMOs while considering capabilities, capacities, redundancy and quality.\n\n· Provide input for drug product stability programs and help select appropriate packaging for clinical development and commercial use.\n\n· Evaluate, recommend, and manage qualified CDMOs for manufacturing drug products for late-stage clinical trials, scale-up, registration, validation and commercial use. Collaborate with Quality Assurance to manage audits and inspections of CDMOs and on manufacturing investigations.\n\n· Author and review core CMC documents/modules and other submissions and responses to FDA and other Competent Authorities, ensuring strategic oversight and consistency for regulatory interactions, including IND/NDA/MAA/IMPD filings and periodic updates.\n\n· Stay informed on pharmaceutical development and manufacturing industry science, regulatory guidelines and competitive trends to provide informed recommendations.\n\n· Develop and propose objectives in alignment with overall company strategies and plans.\n\n· Collaborate with development and commercial partnerships, including ex-US collaborations, to ensure global alignment and integration of strategies.\n\n· Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies.\n\n· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n· Some domestic and international travel will be required.\n\n· Other duties as assigned.\n\nQUALIFICATIONS:\n\n· PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, Pharmaceutics, or a related discipline with at least 10 years of relevant management experience in a pharma or biotech environment. Candidates with an MSc and relevant experience may also be considered.\n\n· Extensive experience in managing late-stage drug product manufacturing and commercialization activities (registration, process scale up, validation and launch), including oversight of external Contract Manufacturing Organizations (CMOs).\n\n· Experience in developing formulations of small molecule solid oral and parenteral dosage forms is a plus.\n\n· Strong background in drug product manufacturing sciences with experience with multiple solid oral manufacturing approaches such as capsules, tablets, spray drying, granulation, blending, bottling and blistering.\n\n· Demonstrated success in transitioning development assets to commercial products and ongoing support of commercial manufacturing.\n\n· Experience contributing to and developing CMC sections in US and ex-US regulatory filings.\n\n· In-depth knowledge of cGMP regulations, guidance, principles, and best practices related to drug product development and manufacture.\n\n· Proficiency in Failure Modes Effect Analysis (FMEA) and establishment of Critical Process Parameters (CPPs).\n\n· Experience with CDMO selection, management, contracting, and issue resolution.\n\n· Excellent oral and written communication, leadership, and interpersonal skills, with the ability to build credibility and trust both inside and outside the company.\n\n· Proven ability to build and develop high-performing teams, with strong delegation and conflict resolution skills.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"0d0c2f1f-cea2-43be-b3b8-12b0a6420b3c","title":"Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial)","department":"R&D Operations","team":"CMC Drug Product","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-13T18:17:05.843+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/0d0c2f1f-cea2-43be-b3b8-12b0a6420b3c","applyUrl":"https://jobs.ashbyhq.com/xenon/0d0c2f1f-cea2-43be-b3b8-12b0a6420b3c/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial) to join our team. The Director/Senior Director, CMC, Drug Product manages and oversees the late phase process development, validation and commercial manufacturing of cGMP drug products for deployment in late-stage clinical trials and commercial distribution. The Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial) will be a key member of a highly collaborative internal CMC team, primarily managing drug product process validation, launch and commercial manufacturing through CDMOs and CROs.

This position reports to the Executive Director, CMC, Drug Product and will be based out of our Boston, MA, USA in our Needham office or in our Burnaby, BC, Canada office. We will consider other jurisdictions for exceptional candidates. This role is a hybrid position; hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week. The level of the position will be commensurate with the candidate’s education and industry experience.

RESPONSIBILITIES:

· Lead teams in late-stage process development and scale up, process validation (PPQ) and commercial manufacturing of small molecule drug products.

· Oversee late phase development and manufacturing processes, ensuring compliance with quality and regulatory standards.

· Manage development activities related to late-stage process development and scale up, FMEA analysis, process validation (PPQ) and preparation for commercial launch of small molecules drug products at partner CDMOs and CMO.

· Manage on going commercial manufacturing and primary packaging of approved small molecule drug products by working with supply chain, quality and regulatory groups. Serve as CMC SME of commercial drug product supply.

· Manage the selection of late-stage and commercial CDMOs while considering capabilities, capacities, redundancy and quality.

· Provide input for drug product stability programs and help select appropriate packaging for clinical development and commercial use.

· Evaluate, recommend, and manage qualified CDMOs for manufacturing drug products for late-stage clinical trials, scale-up, registration, validation and commercial use. Collaborate with Quality Assurance to manage audits and inspections of CDMOs and on manufacturing investigations.

· Author and review core CMC documents/modules and other submissions and responses to FDA and other Competent Authorities, ensuring strategic oversight and consistency for regulatory interactions, including IND/NDA/MAA/IMPD filings and periodic updates.

· Stay informed on pharmaceutical development and manufacturing industry science, regulatory guidelines and competitive trends to provide informed recommendations.

· Develop and propose objectives in alignment with overall company strategies and plans.

· Collaborate with development and commercial partnerships, including ex-US collaborations, to ensure global alignment and integration of strategies.

· Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies.

· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

· Some domestic and international travel will be required.

· Other duties as assigned.

QUALIFICATIONS:

· PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, Pharmaceutics, or a related discipline with at least 10 years of relevant management experience in a pharma or biotech environment. Candidates with an MSc and relevant experience may also be considered.

· Extensive experience in managing late-stage drug product manufacturing and commercialization activities (registration, process scale up, validation and launch), including oversight of external Contract Manufacturing Organizations (CMOs).

· Experience in developing formulations of small molecule solid oral and parenteral dosage forms is a plus.

· Strong background in drug product manufacturing sciences with experience with multiple solid oral manufacturing approaches such as capsules, tablets, spray drying, granulation, blending, bottling and blistering.

· Demonstrated success in transitioning development assets to commercial products and ongoing support of commercial manufacturing.

· Experience contributing to and developing CMC sections in US and ex-US regulatory filings.

· In-depth knowledge of cGMP regulations, guidance, principles, and best practices related to drug product development and manufacture.

· Proficiency in Failure Modes Effect Analysis (FMEA) and establishment of Critical Process Parameters (CPPs).

· Experience with CDMO selection, management, contracting, and issue resolution.

· Excellent oral and written communication, leadership, and interpersonal skills, with the ability to build credibility and trust both inside and outside the company.

· Proven ability to build and develop high-performing teams, with strong delegation and conflict resolution skills.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial) to join our team. The Director/Senior Director, CMC, Drug Product manages and oversees the late phase process development, validation and commercial manufacturing of cGMP drug products for deployment in late-stage clinical trials and commercial distribution. The Director/Senior Director, CMC, Drug Product Manufacturing (Late Stage/Commercial) will be a key member of a highly collaborative internal CMC team, primarily managing drug product process validation, launch and commercial manufacturing through CDMOs and CROs.\n\nThis position reports to the Executive Director, CMC, Drug Product and will be based out of our Boston, MA, USA in our Needham office or in our Burnaby, BC, Canada office. We will consider other jurisdictions for exceptional candidates. This role is a hybrid position; hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week. The level of the position will be commensurate with the candidate’s education and industry experience.\n\nRESPONSIBILITIES:\n\n· Lead teams in late-stage process development and scale up, process validation (PPQ) and commercial manufacturing of small molecule drug products.\n\n· Oversee late phase development and manufacturing processes, ensuring compliance with quality and regulatory standards.\n\n· Manage development activities related to late-stage process development and scale up, FMEA analysis, process validation (PPQ) and preparation for commercial launch of small molecules drug products at partner CDMOs and CMO.\n\n· Manage on going commercial manufacturing and primary packaging of approved small molecule drug products by working with supply chain, quality and regulatory groups. Serve as CMC SME of commercial drug product supply.\n\n· Manage the selection of late-stage and commercial CDMOs while considering capabilities, capacities, redundancy and quality.\n\n· Provide input for drug product stability programs and help select appropriate packaging for clinical development and commercial use.\n\n· Evaluate, recommend, and manage qualified CDMOs for manufacturing drug products for late-stage clinical trials, scale-up, registration, validation and commercial use. Collaborate with Quality Assurance to manage audits and inspections of CDMOs and on manufacturing investigations.\n\n· Author and review core CMC documents/modules and other submissions and responses to FDA and other Competent Authorities, ensuring strategic oversight and consistency for regulatory interactions, including IND/NDA/MAA/IMPD filings and periodic updates.\n\n· Stay informed on pharmaceutical development and manufacturing industry science, regulatory guidelines and competitive trends to provide informed recommendations.\n\n· Develop and propose objectives in alignment with overall company strategies and plans.\n\n· Collaborate with development and commercial partnerships, including ex-US collaborations, to ensure global alignment and integration of strategies.\n\n· Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies.\n\n· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n· Some domestic and international travel will be required.\n\n· Other duties as assigned.\n\nQUALIFICATIONS:\n\n· PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, Pharmaceutics, or a related discipline with at least 10 years of relevant management experience in a pharma or biotech environment. Candidates with an MSc and relevant experience may also be considered.\n\n· Extensive experience in managing late-stage drug product manufacturing and commercialization activities (registration, process scale up, validation and launch), including oversight of external Contract Manufacturing Organizations (CMOs).\n\n· Experience in developing formulations of small molecule solid oral and parenteral dosage forms is a plus.\n\n· Strong background in drug product manufacturing sciences with experience with multiple solid oral manufacturing approaches such as capsules, tablets, spray drying, granulation, blending, bottling and blistering.\n\n· Demonstrated success in transitioning development assets to commercial products and ongoing support of commercial manufacturing.\n\n· Experience contributing to and developing CMC sections in US and ex-US regulatory filings.\n\n· In-depth knowledge of cGMP regulations, guidance, principles, and best practices related to drug product development and manufacture.\n\n· Proficiency in Failure Modes Effect Analysis (FMEA) and establishment of Critical Process Parameters (CPPs).\n\n· Experience with CDMO selection, management, contracting, and issue resolution.\n\n· Excellent oral and written communication, leadership, and interpersonal skills, with the ability to build credibility and trust both inside and outside the company.\n\n· Proven ability to build and develop high-performing teams, with strong delegation and conflict resolution skills.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"8ad91472-aba0-4b71-a351-d98ab22273a3","title":"Senior Manager/Associate Director, Quality Control","department":"R&D Operations","team":"CMC Quality Control","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-14T17:12:08.239+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/8ad91472-aba0-4b71-a351-d98ab22273a3","applyUrl":"https://jobs.ashbyhq.com/xenon/8ad91472-aba0-4b71-a351-d98ab22273a3/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking an experienced Senior Manager/Associate Director, Quality Control to lead Quality Control activities supporting clinical and commercial drug substance (DS) and drug product (DP) programs in accordance with ICH and cGMP requirements. The ideal candidate will have a strong background in small molecules, with experience spanning early to late clinical phases through registration, PPQ, and commercial stages. This role requires expertise in managing analytical testing, specifications, stability program, reference standards, investigations, and quality control oversight across DS and DP manufacturing and testing campaigns. The ideal candidate will be collaborative, science and data driven, and thrive working in a fast-paced environment.

This position reports to the Director, Quality Control and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking an experienced Senior Manager/Associate Director, Quality Control to lead Quality Control activities supporting clinical and commercial drug substance (DS) and drug product (DP) programs in accordance with ICH and cGMP requirements. The ideal candidate will have a strong background in small molecules, with experience spanning early to late clinical phases through registration, PPQ, and commercial stages. This role requires expertise in managing analytical testing, specifications, stability program, reference standards, investigations, and quality control oversight across DS and DP manufacturing and testing campaigns. The ideal candidate will be collaborative, science and data driven, and thrive working in a fast-paced environment.\n\nThis position reports to the Director, Quality Control and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.\n\nRESPONSIBILITIES:\n\n - Review, manage all analytical/non-analytical results for product release, and stability, including OOS and OOT observations. Organize and file internal and external quality control data, protocols, and reports.\n\n - Lead the assigned program’s stability activities, including trending, statistical evaluation, and scientific interpretation of stability data to assess product performance throughout its lifecycle, support shelf-life extensions and expiry dating justifications, and proactively identify and evaluate emerging stability risks and trends.\n\n - Manage the reference standard program for the assigned clinical/commercial program at dedicated external labs, including qualification and distribution of reference standards to all manufacturing & testing facilities.\n\n - Manage master specifications for starting materials, reference standards, API, and drug products for assigned clinical/commercial program(s).\n\n - Manage stability studies for reference standards, API, and drug products for assigned programs. Compile stability protocols and monitor all stability data, including shelf-life trending and extensions.\n\n - Lead investigations and draft reports for out-of-specification (OOS) and out-of-trend (OOT) results during release and stability testing in close collaboration with internal teams and external testing labs.\n\n - Manage the review and approval workflow for feasibility/comparability studies, validation protocols, reports, and test methods with internal experts and external partners.\n\n - Lead quality control checks on the CMC sections of regulatory submissions (e.g., Investigational New Drugs (INDs), Clinical Trial Applications (CTAs), and New Drug Applications (NDAs).\n\n - In collaboration with QA, manage internal release documents for drug substances, drug products, and reference standards, including Certificate of Analysis and Certificate of Testing in collaboration with quality assurance.\n\n - Effectively collaborate with colleagues in Drug Product and API groups, such that deliverables are optimal for use in clinical trial material.\n\n - Ensure effective working relationships with external laboratories and CMOs, participate in remote audits, and perform on-site audits as required.\n\n - Provide technical knowledge of quality control to support the transfer of new drug candidates from research/discovery groups to the CMC drug development team.\n\n - Oversee the movement of samples between external testing partners and CMOs for tech transfers, release, and stability testing of assigned program(s).\n\n - Engage in and ensure compliance with appropriate quality functions, including deviations, change controls, and CAPAs.\n\n - May recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n - Some international travel may be required.\n\n - Other duties as assigned.\n\nQUALIFICATIONS:\n\n - An undergraduate degree in life sciences, with 5+ years (Senior Manager level) or 8+ years (Associate Director level) of relevant management experience in the pharmaceutical industry (small molecules and/or biologics).\n\n - Previous experience working with external testing laboratories; independently and influences in a fast-paced environment, while exhibiting a strong quality mindset.\n\n - Comfortable working across locations and time zones.\n\n - Experience auditing external laboratories, FDA/EMA inspections, and inspection readiness is preferred.\n\n - Strong experience with quality control testing, stability program management in accordance with ICH guidelines, master specifications, method validations, investigations (OOS/OOT), batch release processes, and quality management systems are required.\n\n - Prior experience with IND, NDA and/or CTA CMC submissions is preferred; knowledge of cGMP and the US, Canadian, and EU regulatory environments.\n\n - Collaboration and inclusion between external testing labs and cross-functional CMC teams are essential.\n\n - Excellent oral and written communication skills and previous team leadership experience.\n\n - Willingness to travel up to 20% of the time domestically and internationally.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"4e053aed-9da4-48ee-9b1b-39d242e00ade","title":"Director/Senior Director, CMC, Drug Substance","department":"R&D Operations","team":"CMC Drug Substance","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-13T18:13:13.880+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/4e053aed-9da4-48ee-9b1b-39d242e00ade","applyUrl":"https://jobs.ashbyhq.com/xenon/4e053aed-9da4-48ee-9b1b-39d242e00ade/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Director/Senior Director, CMC, Drug Substance to join our team. The Director/Senior Director, CMC Drug Substance will help manage and oversee the development and manufacturing of cGMP small molecule active pharmaceutical ingredients (APIs) for late-stage clinical trials through validation. The Director/Senior Director will be a key member of a highly collaborative internal CMC team, primarily managing API development programs and manufacturing campaigns (i.e. registration, validation), and managing contract development and manufacturing organization (CDMO) selection and technical transfer processes.

This position reports to the Executive Director, CMC, Drug Substance and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.

RESPONSIBILITIES:

· Manage and oversee the development and manufacturing of small molecule APIs in accordance with applicable quality and regulatory standards.

· Evaluate, recommend, and manage qualified CDMOs for the manufacture of API for clinical trials, as well as for commercial use.

· Serving as the subject matter expert, participate in audits and inspections of API CDMOs in conjunction with Quality Assurance.

· Collaborating closely with the internal process chemistry team, manage API process technology transfer to the Company’s CDMOs, including process validation and the establishment and refinement of suitable specifications for APIs.

· Work closely with Supply Chain and CMC Drug Product colleagues to translate demand forecasts (both clinical and commercial) into API manufacturing plans.

· Author (in conjunction with Technical Writing) and/or act as a key reviewer of core CMC documents/modules and other forms of submissions and responses to FDA and other Competent Authorities providing strategic oversight and consistency for regulatory interactions, including, but not limited to, IND/NDA/MAA/IMPD filings and periodic updates thereto.

· Plan and manage API-related budget proposals and approved project budgets in accordance with the Company’s strategic and operating plans and Finance policies.

· Recruit, lead, direct, develop, coach and evaluate direct reports in accordance with the Company’s Human Resource policies and practices.

· Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans.

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

· Some international travel may be required.

· Other duties as assigned.

QUALIFICATIONS:

· PhD in Chemistry, Chemical Engineering or other relevant discipline with a minimum of 10 years of directly-related experience in a pharma or biotech environment. Candidates with a MSc and significant relevant experience may be considered as well.

· Demonstrated track record in successfully managing development-stage and/or commercial-stage API manufacturing activities conducted at CDMOs.

· Experience authoring/co-authoring key CMC sections in U.S. NDA and European MAA filings for small molecule APIs.

· Extensive knowledge of cGMP-related regulations, guidance documents, principles and best practices pertinent to APIs.

· Experience with CDMO selection, vendor management, contracting, issue resolution and management.

· Excellent written and oral communication skills, including the ability to communicate with scientific and non-scientific personnel and experience in applying risk-based decision-making tools.

· Excellent oral and written communication and interpersonal skills as well as the ability to build credibility and trust inside and outside the Company.

· Excellent attention to detail and commitment to providing accurate, high-quality work.

· Good organizational skills and the ability to manage multiple competing priorities.

· Strong interpersonal and team skills to work both independently and collaboratively as part of a multidisciplinary team.

· Be science- and data-driven while at the same time, creative and flexible in strategic thinking and problem solving.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Director/Senior Director, CMC, Drug Substance to join our team. The Director/Senior Director, CMC Drug Substance will help manage and oversee the development and manufacturing of cGMP small molecule active pharmaceutical ingredients (APIs) for late-stage clinical trials through validation. The Director/Senior Director will be a key member of a highly collaborative internal CMC team, primarily managing API development programs and manufacturing campaigns (i.e. registration, validation), and managing contract development and manufacturing organization (CDMO) selection and technical transfer processes.\n\nThis position reports to the Executive Director, CMC, Drug Substance and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.\n\nRESPONSIBILITIES:\n\n· Manage and oversee the development and manufacturing of small molecule APIs in accordance with applicable quality and regulatory standards.\n\n· Evaluate, recommend, and manage qualified CDMOs for the manufacture of API for clinical trials, as well as for commercial use.\n\n· Serving as the subject matter expert, participate in audits and inspections of API CDMOs in conjunction with Quality Assurance.\n\n· Collaborating closely with the internal process chemistry team, manage API process technology transfer to the Company’s CDMOs, including process validation and the establishment and refinement of suitable specifications for APIs.\n\n· Work closely with Supply Chain and CMC Drug Product colleagues to translate demand forecasts (both clinical and commercial) into API manufacturing plans.\n\n· Author (in conjunction with Technical Writing) and/or act as a key reviewer of core CMC documents/modules and other forms of submissions and responses to FDA and other Competent Authorities providing strategic oversight and consistency for regulatory interactions, including, but not limited to, IND/NDA/MAA/IMPD filings and periodic updates thereto.\n\n· Plan and manage API-related budget proposals and approved project budgets in accordance with the Company’s strategic and operating plans and Finance policies.\n\n· Recruit, lead, direct, develop, coach and evaluate direct reports in accordance with the Company’s Human Resource policies and practices.\n\n· Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans.\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n· Some international travel may be required.\n\n· Other duties as assigned.\n\nQUALIFICATIONS:\n\n· PhD in Chemistry, Chemical Engineering or other relevant discipline with a minimum of 10 years of directly-related experience in a pharma or biotech environment. Candidates with a MSc and significant relevant experience may be considered as well.\n\n· Demonstrated track record in successfully managing development-stage and/or commercial-stage API manufacturing activities conducted at CDMOs.\n\n· Experience authoring/co-authoring key CMC sections in U.S. NDA and European MAA filings for small molecule APIs.\n\n· Extensive knowledge of cGMP-related regulations, guidance documents, principles and best practices pertinent to APIs.\n\n· Experience with CDMO selection, vendor management, contracting, issue resolution and management.\n\n· Excellent written and oral communication skills, including the ability to communicate with scientific and non-scientific personnel and experience in applying risk-based decision-making tools.\n\n· Excellent oral and written communication and interpersonal skills as well as the ability to build credibility and trust inside and outside the Company.\n\n· Excellent attention to detail and commitment to providing accurate, high-quality work.\n\n· Good organizational skills and the ability to manage multiple competing priorities.\n\n· Strong interpersonal and team skills to work both independently and collaboratively as part of a multidisciplinary team.\n\n· Be science- and data-driven while at the same time, creative and flexible in strategic thinking and problem solving.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"1e8ad10c-bb67-4a45-a4d8-e71698f84af2","title":"Executive Director, Total Rewards","department":"General & Administration","team":"Human Resources","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-05-14T17:15:15.695+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/1e8ad10c-bb67-4a45-a4d8-e71698f84af2","applyUrl":"https://jobs.ashbyhq.com/xenon/1e8ad10c-bb67-4a45-a4d8-e71698f84af2/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking an Executive Director, Total Rewards to join our team. The Executive Director, Total Rewards will be a key member of a highly collaborative HR team and will evolve, develop, and manage the execution of total compensation strategies and programs to align with near- and long-term business objectives, our culture and values, and are market competitive to enable Xenon to attract, reward, and retain top talent in the U.S. and Canada.

The Executive Director, Total Rewards will be a strategic thinker who is also highly hands-on and enjoys getting into the details to ensure our programs have well-articulated principles and design, robust end-to-end processes, and flawless execution. The Executive Director, Total Rewards will propose and lead benefits program design in the US and depending on qualifications and experience, Canada. In addition, the successful candidate will have proven leadership ability in a fast-paced, multi-jurisdiction environment and will interact with all levels of internal staff, as well as external advisors and suppliers. This is a hands-on role with plans to grow a team in accordance with business need.

The Executive Director, Total Rewards will work closely with a broad range of internal and external partners, including organization leaders, HR Business Partners (HRBPs), Finance and Legal colleagues and external compensation advisors and suppliers. In collaboration with other key functions, the position will ensure compliance with legal and regulatory requirements in the U.S. and Canada as relates to compensation.

This position reports to the Executive Vice President, Human Resources and will be based out of Vancouver, BC, Canada or Boston, MA, USA in our Needham office. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

· In accordance with Xenon’s total rewards philosophy, and in collaboration with the EVP, HR and external advisors, lead the design, implementation and governance of competitive, integrated total rewards strategies (base, bonus, equity, recognition, benefits) to attract key talent, reward high performance, and support employee retention in Canada and the US

· Lead and manage the base salary program including, but not limited to, budget and forecast (i.e. workforce planning, annual review), job design and matching, salary ranges (i.e. preparation and approval, maintenance, pay transparency, legal compliance), annual and promotion increase guidance, and metrics & analysis; provide guidance and coaching to HRBPs to enable delivery of consistent, expert counsel to organization leaders; work with HR Operations and Finance/Payroll to ensure compensation and promotion related activities are completed accurately and in a timely fashion

· Lead and manage incentive compensation for non-Sales employees; collaborate on program design with Sales Management and Commercial HRBP for Sales employees; ensure incentive compensation plans are aligned with performance expectations; work with program lead for performance management to ensure robust and well-articulated program alignment

· In collaboration with key executive leaders and the Compensation Committee, coordinate the design, evolution and management of equity programs, including stock options, full value share plans, and potentially in future, deferred compensation programs

· Support the Executive Vice President, Human Resources in managing external compensation consultants and developing materials for the Compensation Committee and Board of Directors

· Review and provide input on various compensation governance reports, including, for example, proxy Compensation and Discussion Analysis, collaborating with Finance and Legal as required

· Lead and manage non-financial employee recognition programs in collaboration with HRBPs and HR Operations

· Lead and manage US benefits, including health related and 401(k), from design proposals supported by external advisors and industry benchmarking to contracting to employee communications to governance

· Oversee compensation details to enable accurate forecasting for the Annual Operating Plan and 5-year Plan financial data

· Collaborate with HRBPs in continued evolution of Xenon’s Career Framework, particularly as it relates to compensation philosophy and programs

· Collaborate with the HR systems and data team to review and recommend systems to streamline compensation and other reward programs in accordance with Company and HR systems roadmap

· Manage participation in a variety of compensation surveys in Canada and US

· Collaborate with HRBPs and other key functions, such as Finance, to create communication strategies for total rewards programs to foster employee and candidate understanding and appreciation of Xenon’s total compensation packages.

· Develop strong relationships with leaders and internal partners, based on a high level of collaboration, transparency and agility to inform total rewards programs that align with business objectives

· Maintain an up-to-date knowledge on life sciences compensation trends and governance; drive thought leadership to address current and emerging trends and challenges

· Act as a champion for Xenon’s evolving culture and values

· Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans

· Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies

· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any

· Some international travel may be required

· Other duties as assigned

QUALIFICATIONS:

· At minimum a relevant undergraduate degree, including coursework in math, accounting, finance and/or law; MBA strongly preferred

· 15+ years of experience in progressive compensation/HR management roles in a public, multi-national company life sciences organizations experiencing rapid growth and change; experience in both pre-commercial and commercial companies strongly preferred; ideally experience preparing materials for and interacting with the Board and/or Compensation Committee

· Deep business acumen and understanding of how business strategy in biopharma affects total rewards

· Deep hands-on experience and expertise in data and systems, very strong attention to detail

· Strong analytical and conceptual capability, problem solving, and business planning skills; ability to develop and successfully execute strategies at an organizational level

· Ability to adapt and quickly pivot according to business needs

· Excellent written and oral communication skills, including related to compensation context and employee messaging, to executive and non-executive audiences

· Ability to collaborate effectively and build relationships with key stakeholders

· Impeccable integrity, dependability, and a keen sense of urgency to achieve results

· Ability to execute against multiple high priority projects through exceptional organizational, prioritization and project management skills

· Strong skills in Office software, HR and Finance systems and data

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking an Executive Director, Total Rewards to join our team. The Executive Director, Total Rewards will be a key member of a highly collaborative HR team and will evolve, develop, and manage the execution of total compensation strategies and programs to align with near- and long-term business objectives, our culture and values, and are market competitive to enable Xenon to attract, reward, and retain top talent in the U.S. and Canada.\n\nThe Executive Director, Total Rewards will be a strategic thinker who is also highly hands-on and enjoys getting into the details to ensure our programs have well-articulated principles and design, robust end-to-end processes, and flawless execution. The Executive Director, Total Rewards will propose and lead benefits program design in the US and depending on qualifications and experience, Canada. In addition, the successful candidate will have proven leadership ability in a fast-paced, multi-jurisdiction environment and will interact with all levels of internal staff, as well as external advisors and suppliers. This is a hands-on role with plans to grow a team in accordance with business need.\n\nThe Executive Director, Total Rewards will work closely with a broad range of internal and external partners, including organization leaders, HR Business Partners (HRBPs), Finance and Legal colleagues and external compensation advisors and suppliers. In collaboration with other key functions, the position will ensure compliance with legal and regulatory requirements in the U.S. and Canada as relates to compensation.\n\nThis position reports to the Executive Vice President, Human Resources and will be based out of Vancouver, BC, Canada or Boston, MA, USA in our Needham office. Hybrid positions require a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\n· In accordance with Xenon’s total rewards philosophy, and in collaboration with the EVP, HR and external advisors, lead the design, implementation and governance of competitive, integrated total rewards strategies (base, bonus, equity, recognition, benefits) to attract key talent, reward high performance, and support employee retention in Canada and the US\n\n· Lead and manage the base salary program including, but not limited to, budget and forecast (i.e. workforce planning, annual review), job design and matching, salary ranges (i.e. preparation and approval, maintenance, pay transparency, legal compliance), annual and promotion increase guidance, and metrics & analysis; provide guidance and coaching to HRBPs to enable delivery of consistent, expert counsel to organization leaders; work with HR Operations and Finance/Payroll to ensure compensation and promotion related activities are completed accurately and in a timely fashion\n\n· Lead and manage incentive compensation for non-Sales employees; collaborate on program design with Sales Management and Commercial HRBP for Sales employees; ensure incentive compensation plans are aligned with performance expectations; work with program lead for performance management to ensure robust and well-articulated program alignment\n\n· In collaboration with key executive leaders and the Compensation Committee, coordinate the design, evolution and management of equity programs, including stock options, full value share plans, and potentially in future, deferred compensation programs\n\n· Support the Executive Vice President, Human Resources in managing external compensation consultants and developing materials for the Compensation Committee and Board of Directors\n\n· Review and provide input on various compensation governance reports, including, for example, proxy Compensation and Discussion Analysis, collaborating with Finance and Legal as required\n\n· Lead and manage non-financial employee recognition programs in collaboration with HRBPs and HR Operations\n\n· Lead and manage US benefits, including health related and 401(k), from design proposals supported by external advisors and industry benchmarking to contracting to employee communications to governance\n\n· Oversee compensation details to enable accurate forecasting for the Annual Operating Plan and 5-year Plan financial data\n\n· Collaborate with HRBPs in continued evolution of Xenon’s Career Framework, particularly as it relates to compensation philosophy and programs\n\n· Collaborate with the HR systems and data team to review and recommend systems to streamline compensation and other reward programs in accordance with Company and HR systems roadmap\n\n· Manage participation in a variety of compensation surveys in Canada and US\n\n· Collaborate with HRBPs and other key functions, such as Finance, to create communication strategies for total rewards programs to foster employee and candidate understanding and appreciation of Xenon’s total compensation packages.\n\n· Develop strong relationships with leaders and internal partners, based on a high level of collaboration, transparency and agility to inform total rewards programs that align with business objectives\n\n· Maintain an up-to-date knowledge on life sciences compensation trends and governance; drive thought leadership to address current and emerging trends and challenges\n\n· Act as a champion for Xenon’s evolving culture and values\n\n· Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans\n\n· Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies\n\n· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n· Some international travel may be required\n\n· Other duties as assigned\n\nQUALIFICATIONS:\n\n· At minimum a relevant undergraduate degree, including coursework in math, accounting, finance and/or law; MBA strongly preferred\n\n· 15+ years of experience in progressive compensation/HR management roles in a public, multi-national company life sciences organizations experiencing rapid growth and change; experience in both pre-commercial and commercial companies strongly preferred; ideally experience preparing materials for and interacting with the Board and/or Compensation Committee\n\n· Deep business acumen and understanding of how business strategy in biopharma affects total rewards\n\n· Deep hands-on experience and expertise in data and systems, very strong attention to detail\n\n· Strong analytical and conceptual capability, problem solving, and business planning skills; ability to develop and successfully execute strategies at an organizational level\n\n· Ability to adapt and quickly pivot according to business needs\n\n· Excellent written and oral communication skills, including related to compensation context and employee messaging, to executive and non-executive audiences\n\n· Ability to collaborate effectively and build relationships with key stakeholders\n\n· Impeccable integrity, dependability, and a keen sense of urgency to achieve results\n\n· Ability to execute against multiple high priority projects through exceptional organizational, prioritization and project management skills\n\n· Strong skills in Office software, HR and Finance systems and data\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"173400f9-4eb6-4f3b-ac54-b0d41c724943","title":"Senior Manager, Data Management","department":"Clinical Development","team":"Clinical Data Management","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-06-03T17:37:11.524+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/173400f9-4eb6-4f3b-ac54-b0d41c724943","applyUrl":"https://jobs.ashbyhq.com/xenon/173400f9-4eb6-4f3b-ac54-b0d41c724943/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Manager/Senior Manager, Data Management to join our team. The Manager/Senior Manager will lead and manage data management activities for assigned products, product candidates and/or clinical trials in all phases of clinical development (Phases 1-4). The Manager/Senior Manager will be a key member of a highly collaborative Clinical Development team. The Manager/Senior Manager will thrive in a fast paced, multi-location environment and interact with internal cross-functional colleagues, as well as external stakeholders, including, but not limited to CROs.

This position reports to the Executive Director, Data Management and will be based out of Boston, MA, USA in our Needham office. Boston based positions require a minimum of two onsite days per week. We may consider other jurisdictions for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Manager/Senior Manager, Data Management to join our team. The Manager/Senior Manager will lead and manage data management activities for assigned products, product candidates and/or clinical trials in all phases of clinical development (Phases 1-4). The Manager/Senior Manager will be a key member of a highly collaborative Clinical Development team. The Manager/Senior Manager will thrive in a fast paced, multi-location environment and interact with internal cross-functional colleagues, as well as external stakeholders, including, but not limited to CROs.\n\nThis position reports to the Executive Director, Data Management and will be based out of Boston, MA, USA in our Needham office. Boston based positions require a minimum of two onsite days per week. We may consider other jurisdictions for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience.\n\nRESPONSIBILITIES:\n\n - In collaboration with Clinical Sciences, Biostatistics, Clinical Operations, and other key Development functions, responsible for the design of clinical trial databases, which includes, but not limited to, CRF Development, Database Validation, and Data Review tools in accordance with ICH/GCP guidelines and current regulatory requirements.\n\n - Oversee external data management vendors in respect to key performance indicators, metrics, program level deliverables, timelines, and budgets; may participate in vendor selection activities.\n\n - Optimize data management and collection activities by reviewing protocols for cross-trial consistency and identifying standard case report form modules.\n\n - May support the creation of SDTM datasets, which may include oversight of external vendors.\n\n - Maintain current knowledge of relevant issues related to data management, Health Authority regulations, and competitive trends to provide input and recommendations.\n\n - May propose, draft, and maintain relevant Standard Operating Procedures and other policies and procedures relevant to the department; may participate in systems selection and implementation activities.\n\n - International travel may be required.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics.\n\n - Other duties as assigned.\n\nQUALIFICATIONS:\n\n - Bachelor’s degree in a scientific, medical, computer science or related field; Master’s degree preferred.\n\n - A minimum of 5 years’ management level experience in a pharma or biotech environment. Job level commensurate with years of experience.\n\n - Strong experience in data management-related activities, with thorough understanding of the clinical trial process and regulatory requirements, including CDISC.\n\n - Strong experience in design and validating EDC databases and performing data review; familiar with safety laboratory data management and dictionary coding for adverse events and medications.\n\n - Experience in CNS, pediatric rare disease area and e-diary database design and implementation are preferred.\n\n - Experience in CRO management.\n\n - Ability to be hands-on with database cleaning, generate patient level listings as needed.\n\n - Excellent leadership and interpersonal skills, ability to build credibility and trust inside and outside the Company.\n\n - Proven ability to collaborate in high performing teams, excellent conflict resolution skills.\n\n - Be science and data driven while at the same time, be creative and flexible in strategic thinking and problem solving.\n\n - Ability to travel up to 10%, both domestically and internationally.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"42b0faf3-4757-40ba-baa8-c1a6908a440c","title":"Senior Manager, Data Management","department":"Clinical Development","team":"Clinical Data Management","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-06-02T20:20:08.211+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/42b0faf3-4757-40ba-baa8-c1a6908a440c","applyUrl":"https://jobs.ashbyhq.com/xenon/42b0faf3-4757-40ba-baa8-c1a6908a440c/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Manager/Senior Manager, Data Management to join our team. The Manager/Senior Manager will lead and manage data management activities for assigned products, product candidates and/or clinical trials in all phases of clinical development (Phases 1-4). The Manager/Senior Manager will be a key member of a highly collaborative Clinical Development team. The Manager/Senior Manager will thrive in a fast paced, multi-location environment and interact with internal cross-functional colleagues, as well as external stakeholders, including, but not limited to CROs.

This position reports to the Director, Data Management and is based out of Xenon’s Vancouver, BC office. Vancouver based positions require a minimum of two onsite days per week. We will consider other jurisdictions for exceptional candidates. The level of the position may be commensurate with the candidate’s education and industry experience.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Manager/Senior Manager, Data Management to join our team. The Manager/Senior Manager will lead and manage data management activities for assigned products, product candidates and/or clinical trials in all phases of clinical development (Phases 1-4). The Manager/Senior Manager will be a key member of a highly collaborative Clinical Development team. The Manager/Senior Manager will thrive in a fast paced, multi-location environment and interact with internal cross-functional colleagues, as well as external stakeholders, including, but not limited to CROs.\n\nThis position reports to the Director, Data Management and is based out of Xenon’s Vancouver, BC office. Vancouver based positions require a minimum of two onsite days per week. We will consider other jurisdictions for exceptional candidates. The level of the position may be commensurate with the candidate’s education and industry experience.\n\nRESPONSIBILITIES:\n\n - In collaboration with Clinical Sciences, Biostatistics, Clinical Operations, and other key Development functions, responsible for the design of clinical trial databases, which includes, but not limited to, CRF Development, Database Validation, and Data Review tools in accordance with ICH/GCP guidelines and current regulatory requirements.\n\n - Oversee external data management vendors in respect to key performance indicators, metrics, program level deliverables, timelines, and budgets; may participate in vendor selection activities.\n\n - Optimize data management and collection activities by reviewing protocols for cross-trial consistency and identifying standard case report form modules.\n\n - May support the creation of SDTM datasets, which may include oversight of external vendors.\n\n - Maintain current knowledge of relevant issues related to data management, Health Authority regulations, and competitive trends to provide input and recommendations.\n\n - May propose, draft, and maintain relevant Standard Operating Procedures and other policies and procedures relevant to the department; may participate in systems selection and implementation activities.\n\n - International travel may be required.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics.\n\n - Other duties as assigned.\n\nQUALIFICATIONS:\n\n - Bachelor’s degree in a scientific, medical, computer science or related field; Master’s degree preferred.\n\n - A minimum of 5 years’ management level experience in a pharma or biotech environment. Job level commensurate with years of experience.\n\n - Strong experience in data management-related activities, with thorough understanding of the clinical trial process and regulatory requirements, including CDISC.\n\n - Strong experience in design and validating EDC databases and performing data review; familiar with safety laboratory data management and dictionary coding for adverse events and medications.\n\n - Experience in CNS, pediatric rare disease area and e-diary database design and implementation are preferred.\n\n - Experience in CRO management.\n\n - Ability to be hands-on with database cleaning, generate patient level listings as needed.\n\n - Excellent leadership and interpersonal skills, ability to build credibility and trust inside and outside the Company.\n\n - Proven ability to collaborate in high performing teams, excellent conflict resolution skills.\n\n - Be science and data driven while at the same time, be creative and flexible in strategic thinking and problem solving.\n\n - Ability to travel up to 10%, both domestically and internationally.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"f2557918-90c3-48f8-8cc5-e5d7216cb61e","title":"Director/Senior Director, Pharmacovigilance and Drug Safety (Safety Scientist)","department":"Clinical Development","team":"Pharmacovigilance","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-06-11T17:46:13.599+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/f2557918-90c3-48f8-8cc5-e5d7216cb61e","applyUrl":"https://jobs.ashbyhq.com/xenon/f2557918-90c3-48f8-8cc5-e5d7216cb61e/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Director/Senior Director, Pharmacovigilance and Drug Safety (Safety Scientist) to join our Pharmacovigilance and Safety team. The successful candidate is responsible for safety surveillance and development of aggregate safety reports in compliance with global drug safety regulations and departmental procedures. As such, the role is part of a team that performs high quality and timely scientific analysis of safety data, applies critical thinking skills and synthesizes data findings into clear, concise, and evidence-based statements. The successful candidate will be collaborating with safety physicians and risk management team to perform safety surveillance activities through proactive signal detection, ongoing benefit-risk analyses, and safety monitoring/reporting activities for all Xenon’s clinical assets and future marketed products. The successful candidate will author safety documents, reviews safety sections of other documents, for Xenon products throughout the product lifecycle from First-in-Human (FIH) to post-marketing, performs QC, and, when necessary, assists in responding to information requests from Health Authorities for Xenon products, participate in cross-functional Safety Risk Management Team (SRMT) meetings and collaborate with colleagues in Clinical Development, Trial Operations, Clinical Pharmacology, Biostatistics & Programming, Regulatory, Medical Affairs, non-clinical safety lead, QA and Legal departments.

This position reports to the Executive Director, Pharmacovigilance and Drug Safety, and will be based out of Boston, MA, USA in our Needham office. We may consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. For Boston-based candidates, this is a Hybrid position requiring a minimum of two onsite days per week.

RESPONSIBILITIES:

•\tLead the proactive signal detection activities, support the ongoing benefit-risk analyses, and safety monitoring/reporting activities for Xenon products across all stages of development.

•\tLead and manage Aggregate Safety Reports (e.g., IND/NDA Annual Reports, PADER, DSUR, PSUR, PBRER, ad-hoc regulatory responses, etc.) for Xenon products throughout product lifecycle from FIH to post-marketing in compliance with global safety regulations and guidelines and provide training within DSPV and cross-functionally.

•\tAuthor Aggregate Safety Reports while working in collaboration with the cross functional teams (i.e. Non-clinical, Clinical Development, Trial Operations, Regulatory, Biostatistics, and Clinical Data Management) to compile safety information.

•\tSupport and review safety-related documents for Xenon products throughout product lifecycle from FIH to post-marketing such as Safety Assessment Reports, product labeling, risk management/risk mitigation-related documents, and responses to ad-hoc information requests by Health Authorities and internal stakeholders.

•\tReview safety concerns escalated from internal and external stakeholders, including competent regulatory authorities, and support safety team to develop safety related responses.

•\tMaintain continuous monitoring/updating of safety profiles for assigned investigational and marketed products. Collaborates with physicians and risk management team in ongoing risk/benefit assessment.

•\tPerforms careful review of all serious events of interests and expedited individual case safety reports ensuring that the knowledge gained from these individual reports contribute to a higher degree of interpretation, consistency, and quality of the analysis at the aggregate level. Reviews and provides input to Analysis of Similar Events (AoSE), as needed.

•\tReview and communicate trending, signaling, and other safety-related issues originating from any source for the purposes of detecting and reviewing safety signals (e.g., change in frequency, nature, or severity of a safety-related issue) in a timely manner.

•\tParticipates and contributes to cross-functional SRMT meetings for signal management, risk management detection, and benefit-risk assessment for Xenon products.

•\tReview potential issues and safety signals and contribute to the SRMT and Safety Governance process through the preparation and presentation of safety data; prepare and assess safety data for ongoing periodic / aggregate safety data review.

•\tAuthor the safety signal assessment reports in collaboration with Safety Physicians.

•\tSupport the risk management team in the development of risk management strategies and activities.

•\tReview SMP and provide input to safety related sections of clinical study documents including Study Protocols, Informed Consent Forms (ICF), Clinical Study Reports (CSR), SAPs, DSMB charters, and other relevant documents.

•\tWrite and maintain relevant SOPs and procedures in compliance with global regulations and guidelines.

•\tSupport inspections by participating in audit preparedness activities and providing requested information.

•\tAct in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

•\tOther duties as assigned.

QUALIFICATIONS:

•\tHealth Care Professional degree required (e.g., RN/BSN/MSN, NP, PharmD) and 9+ years (Dir)/12+ (Senior Dir) of pharmaceutical industry experience in drug safety & pharmacovigilance as a Safety Scientist for products in the clinical trial and post-marketing environments.

•\tDirector will have a minimum of bachelor’s degree with a minimum of 10+ years management experience in a pharma or biotech environment; Master’s degree preferred.

•\tSenior Director will have a minimum of Master’s degree with a minimum of 8+ years management experience in a pharma or biotech environment.

•\tAbility to lead cross-functional team through all activities in the full clinical study life cycle.

•\tA good understanding of all phases of the drug development process between DSPV, Clinical, Regulatory Affairs, and other functional areas. Demonstrated ability to successfully work across a variety of teams and manage multiple conflicting priorities.

•\tExperience leading and authoring safety signal assessment report, DSUR, PADER, PBRER, and contributing to safety and risk management sections of other regulatory safety reports (RMP, RSIs).

•\tSkilled in signal detection process and managing safety information from clinical development and post-marketing sources.

•\tExperienced with FDA/EMA regulations and ICH guidance governing pharmacovigilance and risk management.

•\tKnowledge of drug development process, pharmacovigilance databases and MedDRA coding.

•\tUnderstanding of clinical disease state and implications of treatment.

•\tAt ease with data handling and visualization, statistics, and technical writing skills.

•\tExperience with use of safety databases, preferably Argus Safety Database and signal detection tools.

•\tStrategic critical thinking skills with focus on data integrity and high-quality outputs.

•\tExcellent verbal and written communication skills with ability to communicate effectively by writing clearly and concisely, and strong presentation skills.

•\tTime management skills with ability to prioritize to meet required deadlines.

•\tAbility to multitask and prioritize under tight deadlines while providing attention to detail and high-quality work in a dynamic environment.

•\tAbility to be flexible, adapt to change, work independently, as well as experience working in a highly collaborative matrix environment.

•\tAbility to work both independently and as part of a multidisciplinary team that is results-oriented.

•\tStrong interpersonal skills and ability to foster strong collaborative relationships with internal and external team members.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role: \n\nWe are seeking a Director/Senior Director, Pharmacovigilance and Drug Safety (Safety Scientist) to join our Pharmacovigilance and Safety team. The successful candidate is responsible for safety surveillance and development of aggregate safety reports in compliance with global drug safety regulations and departmental procedures. As such, the role is part of a team that performs high quality and timely scientific analysis of safety data, applies critical thinking skills and synthesizes data findings into clear, concise, and evidence-based statements. The successful candidate will be collaborating with safety physicians and risk management team to perform safety surveillance activities through proactive signal detection, ongoing benefit-risk analyses, and safety monitoring/reporting activities for all Xenon’s clinical assets and future marketed products. The successful candidate will author safety documents, reviews safety sections of other documents, for Xenon products throughout the product lifecycle from First-in-Human (FIH) to post-marketing, performs QC, and, when necessary, assists in responding to information requests from Health Authorities for Xenon products, participate in cross-functional Safety Risk Management Team (SRMT) meetings and collaborate with colleagues in Clinical Development, Trial Operations, Clinical Pharmacology, Biostatistics & Programming, Regulatory, Medical Affairs, non-clinical safety lead, QA and Legal departments. \n\nThis position reports to the Executive Director, Pharmacovigilance and Drug Safety, and will be based out of Boston, MA, USA in our Needham office. We may consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. For Boston-based candidates, this is a Hybrid position requiring a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\n• Lead the proactive signal detection activities, support the ongoing benefit-risk analyses, and safety monitoring/reporting activities for Xenon products across all stages of development. \n\n• Lead and manage Aggregate Safety Reports (e.g., IND/NDA Annual Reports, PADER, DSUR, PSUR, PBRER, ad-hoc regulatory responses, etc.) for Xenon products throughout product lifecycle from FIH to post-marketing in compliance with global safety regulations and guidelines and provide training within DSPV and cross-functionally. \n\n• Author Aggregate Safety Reports while working in collaboration with the cross functional teams (i.e. Non-clinical, Clinical Development, Trial Operations, Regulatory, Biostatistics, and Clinical Data Management) to compile safety information.\n\n• Support and review safety-related documents for Xenon products throughout product lifecycle from FIH to post-marketing such as Safety Assessment Reports, product labeling, risk management/risk mitigation-related documents, and responses to ad-hoc information requests by Health Authorities and internal stakeholders. \n\n• Review safety concerns escalated from internal and external stakeholders, including competent regulatory authorities, and support safety team to develop safety related responses. \n\n• Maintain continuous monitoring/updating of safety profiles for assigned investigational and marketed products. Collaborates with physicians and risk management team in ongoing risk/benefit assessment.\n\n• Performs careful review of all serious events of interests and expedited individual case safety reports ensuring that the knowledge gained from these individual reports contribute to a higher degree of interpretation, consistency, and quality of the analysis at the aggregate level. Reviews and provides input to Analysis of Similar Events (AoSE), as needed.\n\n• Review and communicate trending, signaling, and other safety-related issues originating from any source for the purposes of detecting and reviewing safety signals (e.g., change in frequency, nature, or severity of a safety-related issue) in a timely manner.\n\n• Participates and contributes to cross-functional SRMT meetings for signal management, risk management detection, and benefit-risk assessment for Xenon products.\n\n• Review potential issues and safety signals and contribute to the SRMT and Safety Governance process through the preparation and presentation of safety data; prepare and assess safety data for ongoing periodic / aggregate safety data review.\n\n• Author the safety signal assessment reports in collaboration with Safety Physicians. \n\n• Support the risk management team in the development of risk management strategies and activities. \n\n• Review SMP and provide input to safety related sections of clinical study documents including Study Protocols, Informed Consent Forms (ICF), Clinical Study Reports (CSR), SAPs, DSMB charters, and other relevant documents.\n\n• Write and maintain relevant SOPs and procedures in compliance with global regulations and guidelines.\n\n• Support inspections by participating in audit preparedness activities and providing requested information.\n\n• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n• Other duties as assigned.\n\nQUALIFICATIONS:\n\n• Health Care Professional degree required (e.g., RN/BSN/MSN, NP, PharmD) and 9+ years (Dir)/12+ (Senior Dir) of pharmaceutical industry experience in drug safety & pharmacovigilance as a Safety Scientist for products in the clinical trial and post-marketing environments.\n\n• Director will have a minimum of bachelor’s degree with a minimum of 10+ years management experience in a pharma or biotech environment; Master’s degree preferred.\n\n• Senior Director will have a minimum of Master’s degree with a minimum of 8+ years management experience in a pharma or biotech environment.\n\n• Ability to lead cross-functional team through all activities in the full clinical study life cycle.\n\n• A good understanding of all phases of the drug development process between DSPV, Clinical, Regulatory Affairs, and other functional areas. Demonstrated ability to successfully work across a variety of teams and manage multiple conflicting priorities. \n\n• Experience leading and authoring safety signal assessment report, DSUR, PADER, PBRER, and contributing to safety and risk management sections of other regulatory safety reports (RMP, RSIs).\n\n• Skilled in signal detection process and managing safety information from clinical development and post-marketing sources.\n\n• Experienced with FDA/EMA regulations and ICH guidance governing pharmacovigilance and risk management.\n\n• Knowledge of drug development process, pharmacovigilance databases and MedDRA coding.\n\n• Understanding of clinical disease state and implications of treatment.\n\n• At ease with data handling and visualization, statistics, and technical writing skills. \n\n• Experience with use of safety databases, preferably Argus Safety Database and signal detection tools.\n\n• Strategic critical thinking skills with focus on data integrity and high-quality outputs.\n\n• Excellent verbal and written communication skills with ability to communicate effectively by writing clearly and concisely, and strong presentation skills.\n\n• Time management skills with ability to prioritize to meet required deadlines.\n\n• Ability to multitask and prioritize under tight deadlines while providing attention to detail and high-quality work in a dynamic environment.\n\n• Ability to be flexible, adapt to change, work independently, as well as experience working in a highly collaborative matrix environment.\n\n• Ability to work both independently and as part of a multidisciplinary team that is results-oriented. \n\n• Strong interpersonal skills and ability to foster strong collaborative relationships with internal and external team members. \n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"a624a435-b080-4e5c-b8a7-71d4a8bd8cdb","title":"Clinical Scientist 2 or 3, Clinical Development","department":"Clinical Development","team":"Clinical Development","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-07-21T20:41:53.276+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/a624a435-b080-4e5c-b8a7-71d4a8bd8cdb","applyUrl":"https://jobs.ashbyhq.com/xenon/a624a435-b080-4e5c-b8a7-71d4a8bd8cdb/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Clinical Scientist 2 or 3, Clinical Development, to join our Clinical Development team. This role is intended for an experienced clinical scientist who can independently contribute to the design, execution, analysis, interpretation, and communication of clinical development activities across assigned programs. The clinical scientist will provide scientific leadership at the study level, contribute meaningfully to program strategy, and serve as a key partner to cross-functional teams to ensure that clinical development plans, study designs, and data packages are scientifically rigorous, operationally feasible, and aligned with evolving regulatory expectations.

This position reports to the Senior Medical Director, Clinical Development, and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. This is a Hybrid position requiring a minimum of two onsite days per week.

RESPONSIBILITIES:

Your duties and responsibilities in this position will include those listed below:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Clinical Scientist 2 or 3, Clinical Development, to join our Clinical Development team. This role is intended for an experienced clinical scientist who can independently contribute to the design, execution, analysis, interpretation, and communication of clinical development activities across assigned programs. The clinical scientist will provide scientific leadership at the study level, contribute meaningfully to program strategy, and serve as a key partner to cross-functional teams to ensure that clinical development plans, study designs, and data packages are scientifically rigorous, operationally feasible, and aligned with evolving regulatory expectations.\n\nThis position reports to the Senior Medical Director, Clinical Development, and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. This is a Hybrid position requiring a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\nYour duties and responsibilities in this position will include those listed below:\n\n - Provide scientific leadership and independent contribution to study design, protocol development, endpoint strategy, and clinical development planning for assigned programs.\n\n - Support the development, implementation, conduct, oversight, and reporting of clinical trials, ensuring scientific quality and alignment with program objectives.\n\n - Perform comprehensive literature reviews and maintain current knowledge of disease areas, competitive landscape, emerging science, and regulatory developments relevant to assigned products and indications.\n\n - Participate in the review, monitoring, summarization, and interpretation of safety, efficacy, pharmacokinetic, patient-reported outcome, and other clinical data to support development decisions and recommendations.\n\n - Collaborate cross-functionally with Clinical Operations, Biometrics/Biostatistics, Data Management, Pharmacovigilance, Medical Writing, Regulatory, Translational Development, Medical Affairs, and other partners to support high-quality study execution and documentation.\n\n - Draft, review, and contribute to clinical and regulatory documents, including study protocols, synopses, investigator brochures, clinical study reports, health authority submission content, briefing materials, abstracts, posters, and manuscripts.\n\n - Support or lead scientific interactions with CROs, investigators, site personnel, and external collaborators to ensure consistency, scientific integrity, and effective study execution.\n\n - Contribute to investigator identification, site feasibility, study start-up, and scientific training activities for study teams, CROs, investigators, and site personnel.\n\n - Develop and maintain productive relationships with external scientific experts, key opinion leaders, and the broader medical community in alignment with development goals.\n\n - Provide critical evaluation of development strategies, identify scientific and operational risks, and help develop contingency and mitigation plans.\n\n - Contribute to advisory boards, expert meetings, and other scientific interactions that support program development and evidence generation.\n\n - Support the development of departmental processes, templates, standard operating procedures, and best practices as needed.\n\n - Development of standard operating procedures (SOPs) and guidelines linked with departmental activities.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n - Other duties as assigned.\n\nQUALIFICATIONS:\n\n - MSc or PhD degree in Life Sciences, Biomedical Sciences, Pharmacology or other professional doctorate in pharmaceutical sciences or a related scientific discipline.\n\n - A Scientist 3 will have at least 5-8 years of post-doctoral experience and/or relevant industry experience, preferably in neurosciences.\n\n - A Scientist 2 will have at least 2-5 years of post-doctoral experience and/or relevant industry experience, preferably in neurosciences.\n\n - Experience in clinical research and clinical development with a strong understanding of study design, study conduct, clinical data review, and interpretation.\n\n - Experience drafting, reviewing, or supporting clinical and regulatory documentation and working effectively in cross-functional teams.\n\n - Working knowledge of GCP, ICH guidelines, and regulatory expectations, including familiarity with FDA and EMA environments.\n\n - Strong written, verbal, interpersonal, and presentation skills, with the ability to communicate effectively to scientific and operational audiences.\n\n - Strong organizational skills, attention to detail, and the ability to work independently while contributing effectively in a team environment.\n\n - Experience in neuroscience, CNS, psychiatry, neurology, or related therapeutic areas is preferred.\n\n - Demonstrated ability to analyze complex scientific information, generate sound recommendations, and solve problems in a dynamic development environment.\n\n - Experience working with investigators, CROs, vendors, and external scientific experts is preferred.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"4477d3b8-ae2f-4377-85d1-0efa5dbe3f1f","title":"Clinical Scientist 2 or 3, Clinical Development","department":"Clinical Development","team":"Clinical Development","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-07-21T20:41:57.723+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/4477d3b8-ae2f-4377-85d1-0efa5dbe3f1f","applyUrl":"https://jobs.ashbyhq.com/xenon/4477d3b8-ae2f-4377-85d1-0efa5dbe3f1f/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Clinical Scientist 2 or 3, Clinical Development, to join our Clinical Development team. This role is intended for an experienced clinical scientist who can independently contribute to the design, execution, analysis, interpretation, and communication of clinical development activities across assigned programs. The clinical scientist will provide scientific leadership at the study level, contribute meaningfully to program strategy, and serve as a key partner to cross-functional teams to ensure that clinical development plans, study designs, and data packages are scientifically rigorous, operationally feasible, and aligned with evolving regulatory expectations.

This position reports to the Senior Medical Director, Clinical Development, and will be based out of our Vancouver, BC office. We may consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. This is a Hybrid position requiring a minimum of two onsite days per week.

RESPONSIBILITIES:

Your duties and responsibilities in this position will include those listed below:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Clinical Scientist 2 or 3, Clinical Development, to join our Clinical Development team. This role is intended for an experienced clinical scientist who can independently contribute to the design, execution, analysis, interpretation, and communication of clinical development activities across assigned programs. The clinical scientist will provide scientific leadership at the study level, contribute meaningfully to program strategy, and serve as a key partner to cross-functional teams to ensure that clinical development plans, study designs, and data packages are scientifically rigorous, operationally feasible, and aligned with evolving regulatory expectations.\n\nThis position reports to the Senior Medical Director, Clinical Development, and will be based out of our Vancouver, BC office. We may consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. This is a Hybrid position requiring a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\nYour duties and responsibilities in this position will include those listed below:\n\n - Provide scientific leadership and independent contribution to study design, protocol development, endpoint strategy, and clinical development planning for assigned programs.\n\n - Support the development, implementation, conduct, oversight, and reporting of clinical trials, ensuring scientific quality and alignment with program objectives.\n\n - Perform comprehensive literature reviews and maintain current knowledge of disease areas, competitive landscape, emerging science, and regulatory developments relevant to assigned products and indications.\n\n - Participate in the review, monitoring, summarization, and interpretation of safety, efficacy, pharmacokinetic, patient-reported outcome, and other clinical data to support development decisions and recommendations.\n\n - Collaborate cross-functionally with Clinical Operations, Biometrics/Biostatistics, Data Management, Pharmacovigilance, Medical Writing, Regulatory, Translational Development, Medical Affairs, and other partners to support high-quality study execution and documentation.\n\n - Draft, review, and contribute to clinical and regulatory documents, including study protocols, synopses, investigator brochures, clinical study reports, health authority submission content, briefing materials, abstracts, posters, and manuscripts.\n\n - Support or lead scientific interactions with CROs, investigators, site personnel, and external collaborators to ensure consistency, scientific integrity, and effective study execution.\n\n - Contribute to investigator identification, site feasibility, study start-up, and scientific training activities for study teams, CROs, investigators, and site personnel.\n\n - Develop and maintain productive relationships with external scientific experts, key opinion leaders, and the broader medical community in alignment with development goals.\n\n - Provide critical evaluation of development strategies, identify scientific and operational risks, and help develop contingency and mitigation plans.\n\n - Contribute to advisory boards, expert meetings, and other scientific interactions that support program development and evidence generation.\n\n - Support the development of departmental processes, templates, standard operating procedures, and best practices as needed.\n\n - Development of standard operating procedures (SOPs) and guidelines linked with departmental activities.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n - Other duties as assigned.\n\nQUALIFICATIONS:\n\n - MSc or PhD degree in Life Sciences, Biomedical Sciences, Pharmacology or other professional doctorate in pharmaceutical sciences or a related scientific discipline.\n\n - A Scientist 3 will have at least 5-8 years of post-doctoral experience and/or relevant industry experience, preferably in neurosciences.\n\n - A Scientist 2 will have at least 2-5 years of post-doctoral experience and/or relevant industry experience, preferably in neurosciences.\n\n - Experience in clinical research and clinical development with a strong understanding of study design, study conduct, clinical data review, and interpretation.\n\n - Experience drafting, reviewing, or supporting clinical and regulatory documentation and working effectively in cross-functional teams.\n\n - Working knowledge of GCP, ICH guidelines, and regulatory expectations, including familiarity with FDA and EMA environments.\n\n - Strong written, verbal, interpersonal, and presentation skills, with the ability to communicate effectively to scientific and operational audiences.\n\n - Strong organizational skills, attention to detail, and the ability to work independently while contributing effectively in a team environment.\n\n - Experience in neuroscience, CNS, psychiatry, neurology, or related therapeutic areas is preferred.\n\n - Demonstrated ability to analyze complex scientific information, generate sound recommendations, and solve problems in a dynamic development environment.\n\n - Experience working with investigators, CROs, vendors, and external scientific experts is preferred.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"e4c56563-5bff-4052-9294-f8dd541a2e1e","title":"Manager, Internal Communications","department":"General & Administration","team":"Corporate Affairs","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-06-26T14:29:16.357+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/e4c56563-5bff-4052-9294-f8dd541a2e1e","applyUrl":"https://jobs.ashbyhq.com/xenon/e4c56563-5bff-4052-9294-f8dd541a2e1e/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Manager, Internal Communications to join our team. This role supports and executes communication strategies to foster the internal mission and vision at Xenon by ensuring a consistent internal communications program that focuses on science and a culture that is built upon our shared Xenon CARES values to improve and enhance the lives of patients and employees. This individual will work with the Corporate Affairs team, and with direction from the Corporate Communication lead, to develop, support and execute tactical implementation for day-to-day internal communications and related programming, including corporate events. This is a high visibility role requiring relationship development and management across the organization, representing the corporate affairs and executive teams in internal, cultural events with the intent of fostering community & connection among our global employee base.

This position reports to the Associate Director, Corporate Communications & Events and will be located in Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office, with some weeks needing more depending on events taking place. There may also be occasional in-person time outside of core business hours executing and/or attending company or sponsored events. Infrequent travel, including international travel, on an ad hoc basis may be required.

RESPONSIBILITIES:

•\tContribute to development of annual and long-term internal communications strategies, objectives and initiatives.

•\tManage internal communications and corporate engagement initiatives that align with departmental goals and company culture using multi-channel communications and event planning.

•\tCollaborate with key stakeholders to develop internal content for the corporate intranet, companywide emails, town halls and department leader meetings, annual leadership summit, and other internal meetings and events.

•\tAct as a Vancouver-based event lead by executing large- and small-scale corporate events within planned budgets and managing project costs, logistics, vendors, and deadlines, partnering with Boston office event captain to align on objectives, deliverables, and timelines.

•\tManage logistics and execution of executive and senior leadership team offsites, partnering with the CEO and key stakeholders to drive alignment on event expectations and delivery.

•\tContribute to forward-looking communications plans and systems for remote employees as well as future commercial and medical field teams.

•\tSource and manage branded items, oversee vendor relationships and project logistics, and ensure consistent application of Xenon’s visual identity across all internal and external materials.

•\tManage contract and invoice tracking and submissions for the Corporate Affairs department.

•\tProactively identify and propose solutions for challenges and/or process improvements within areas of responsibility.

•\tSupport initiatives driven by external communications, patient advocacy, and other corporate affairs functions, as needed.

QUALIFICATIONS:

•\tMinimum Bachelor’s degree required.

•\tCreative thinker with 5+ years experience in communications, marketing, and/or public relations roles, with biopharmaceutical or life sciences experience preferred.

•\tStrong communications skills, including written, verbal, presentation, interpersonal skills, with the ability to support translation and simplification of complex information.

•\tStrong writing skills with experience in content development, generation, and amplification.

•\tExperience with employee engagement.

•\tExperience leading the planning and execution of large-scale events.

•\tHighly organized, with attention to detail, adherence to deadlines, and ability to work independently under pressure with multiple, shifting priorities.

•\tAbility to solve problems and comfortable operating in an agile environment; possess solid experience successfully navigating a growing organization.

•\tAbility to build and retain knowledge of a company, business strategies & objectives to be able to develop support innovative concepts that will work in the organization.

•\tCan effectively interact with all functions, teams, senior leadership, independent contributors, contractors, agency partners and vendors in gaining consensus, developing strategies, or executing a program.

•\tCan build effective, trusted relationships, influence others with confidence, and has the ability to interact with all levels and functions within the organization.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Manager, Internal Communications to join our team. This role supports and executes communication strategies to foster the internal mission and vision at Xenon by ensuring a consistent internal communications program that focuses on science and a culture that is built upon our shared Xenon CARES values to improve and enhance the lives of patients and employees. This individual will work with the Corporate Affairs team, and with direction from the Corporate Communication lead, to develop, support and execute tactical implementation for day-to-day internal communications and related programming, including corporate events. This is a high visibility role requiring relationship development and management across the organization, representing the corporate affairs and executive teams in internal, cultural events with the intent of fostering community & connection among our global employee base.\n\nThis position reports to the Associate Director, Corporate Communications & Events and will be located in Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office, with some weeks needing more depending on events taking place. There may also be occasional in-person time outside of core business hours executing and/or attending company or sponsored events. Infrequent travel, including international travel, on an ad hoc basis may be required.\n\nRESPONSIBILITIES:\n\n• Contribute to development of annual and long-term internal communications strategies, objectives and initiatives.\n\n• Manage internal communications and corporate engagement initiatives that align with departmental goals and company culture using multi-channel communications and event planning.\n\n• Collaborate with key stakeholders to develop internal content for the corporate intranet, companywide emails, town halls and department leader meetings, annual leadership summit, and other internal meetings and events.\n\n• Act as a Vancouver-based event lead by executing large- and small-scale corporate events within planned budgets and managing project costs, logistics, vendors, and deadlines, partnering with Boston office event captain to align on objectives, deliverables, and timelines. \n\n• Manage logistics and execution of executive and senior leadership team offsites, partnering with the CEO and key stakeholders to drive alignment on event expectations and delivery.\n\n• Contribute to forward-looking communications plans and systems for remote employees as well as future commercial and medical field teams.\n\n• Source and manage branded items, oversee vendor relationships and project logistics, and ensure consistent application of Xenon’s visual identity across all internal and external materials.\n\n• Manage contract and invoice tracking and submissions for the Corporate Affairs department.\n\n• Proactively identify and propose solutions for challenges and/or process improvements within areas of responsibility.\n\n• Support initiatives driven by external communications, patient advocacy, and other corporate affairs functions, as needed.\n\nQUALIFICATIONS:\n\n• Minimum Bachelor’s degree required.\n\n• Creative thinker with 5+ years experience in communications, marketing, and/or public relations roles, with biopharmaceutical or life sciences experience preferred.\n\n• Strong communications skills, including written, verbal, presentation, interpersonal skills, with the ability to support translation and simplification of complex information.\n\n• Strong writing skills with experience in content development, generation, and amplification.\n\n• Experience with employee engagement.\n\n• Experience leading the planning and execution of large-scale events.\n\n• Highly organized, with attention to detail, adherence to deadlines, and ability to work independently under pressure with multiple, shifting priorities.\n\n• Ability to solve problems and comfortable operating in an agile environment; possess solid experience successfully navigating a growing organization.\n\n• Ability to build and retain knowledge of a company, business strategies & objectives to be able to develop support innovative concepts that will work in the organization.\n\n• Can effectively interact with all functions, teams, senior leadership, independent contributors, contractors, agency partners and vendors in gaining consensus, developing strategies, or executing a program.\n\n• Can build effective, trusted relationships, influence others with confidence, and has the ability to interact with all levels and functions within the organization. \n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"d82ebb07-e630-42ab-b8a5-cf6bfd35a7f0","title":"Director, Commercial Learning & Field Enablement","department":"Commercial","team":"Sales","employmentType":"FullTime","location":"United States","secondaryLocations":[],"publishedAt":"2026-06-26T14:55:30.285+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressCountry":"United States"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/d82ebb07-e630-42ab-b8a5-cf6bfd35a7f0","applyUrl":"https://jobs.ashbyhq.com/xenon/d82ebb07-e630-42ab-b8a5-cf6bfd35a7f0/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

The Director, Commercial Learning & Field Enablement is responsible for defining and delivering a comprehensive commercial learning strategy that builds field capability, supports launch readiness, and enables sustained commercial performance across Xenon’s U.S. organization.

This role owns the design, development, and delivery of all commercial training programs, ensuring field teams are equipped with the knowledge, skills, and behaviors required to execute effectively. The Director will build and scale a best-in-class learning ecosystem, integrating functional training, leadership development, and enterprise training to support both immediate launch needs and long-term capability building.

Acting as a strategic partner across Sales, Marketing, Market Access, Medical, Commercial Operations, and Human Resources, this role translates commercial strategy into structured, role-specific learning programs that enable field readiness and performance.

This position reports to the Senior Director, Field Strategy & Enablement and is a key member of the extended commercial leadership team. This position will be remote.

RESPONSIBILITIES:

Commercial Learning Strategy & Execution

Commercial Leadership Development

Training Design & Delivery

Commercial Meetings & Learning Integration

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\n\n\nThe Director, Commercial Learning & Field Enablement is responsible for defining and delivering a comprehensive commercial learning strategy that builds field capability, supports launch readiness, and enables sustained commercial performance across Xenon’s U.S. organization. \n\nThis role owns the design, development, and delivery of all commercial training programs, ensuring field teams are equipped with the knowledge, skills, and behaviors required to execute effectively. The Director will build and scale a best-in-class learning ecosystem, integrating functional training, leadership development, and enterprise training to support both immediate launch needs and long-term capability building. \n\nActing as a strategic partner across Sales, Marketing, Market Access, Medical, Commercial Operations, and Human Resources, this role translates commercial strategy into structured, role-specific learning programs that enable field readiness and performance. \n\nThis position reports to the Senior Director, Field Strategy & Enablement and is a key member of the extended commercial leadership team. This position will be remote.\n\n\n\nRESPONSIBILITIES:\n\nCommercial Learning Strategy & Execution \n\n - Define and execute a holistic commercial learning strategy aligned to business priorities and go-to-market objectives \n\n - Design and implement comprehensive training programs across: \n \n - Product, disease state, and market access education \n \n - Selling skills and account-based engagement models \n \n - Systems and tools training \n\n - Build structured learning journeys spanning onboarding, advanced development, and ongoing capability enhancement \n\n - Translate strategic priorities into role-specific, applied learning experiences \n\n - Launch Training & Readiness \n\n - Own training readiness for launch, including curriculum design, certification, and delivery \n\n - Partner with Sales and Marketing to align training to brand strategy, messaging, and milestones \n\n - Ensure field teams are fully prepared with the knowledge and skills required to execute from day one \n\nCommercial Leadership Development \n\n - Design and implement leadership development programs for Regional Sales Managers and emerging leaders \n\n - Equip front-line leaders with frameworks, tools, and approaches to effectively coach and develop their teams \n\n - Partner with HR to align with enterprise leadership development initiatives \n\nTraining Design & Delivery \n\n - Develop high-quality, engaging learning experiences including workshops, virtual sessions, simulations, and e-learning \n\n - Ensure training reflects real-world field scenarios and customer engagement complexity \n\n - Oversee internal subject matter experts and external vendors to ensure consistency and quality \n\n - Capability Assessment & Continuous Improvement \n\n - Assess field capability using structured assessments, training metrics, and input from field leadership and execution teams \n\n - Measure training effectiveness through knowledge outcomes, skill development, and readiness indicators \n\n - Continuously evolve programs based on business needs, performance trends, and field feedback \n\nCommercial Meetings & Learning Integration \n\n - Lead the learning strategy and training components of national and regional meetings \n\n - Align training delivery with the commercial operating cadence to reinforce key priorities \n\n - Additional Responsibilities\n\n - Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans \n\n - Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies \n\n - Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n - Some international travel may be required\n\n - Other duties as assigned\n\nQUALIFICATIONS:\n\n - Bachelor’s degree required; advanced degree preferred \n\n - 10+ years of biopharma commercial experience across sales, training, learning & development, or commercial operations \n\n - Proven experience designing and delivering commercial training programs aligned to launch and performance outcomes \n\n - Deep understanding of adult learning principles and commercial field models \n\n - Experience developing leadership programs for front-line leaders \n\n - Strong facilitation, communication, and stakeholder management skills \n\n - Ability to translate business strategy into measurable capability programs \n\n - Experience with learning systems and platforms preferred \n\n - Willingness to travel up to 40%-50%\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"f7c5f939-f37c-4cbe-b12a-73d5f8e91bb2","title":"Associate Director, Medical Training (Pipeline)","department":"Clinical Development","team":"Medical Affairs","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-06-25T19:48:19.026+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/f7c5f939-f37c-4cbe-b12a-73d5f8e91bb2","applyUrl":"https://jobs.ashbyhq.com/xenon/f7c5f939-f37c-4cbe-b12a-73d5f8e91bb2/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking an Associate Director, Medical Training (Pipeline) to lead the strategy, development, and execution of pipeline training across our therapeutic areas (including epilepsy, major depressive disorder, and bipolar depression) and broader neuroscience portfolio. This role will build scalable, audience-tailored training programs and modules to ensure internal teams are confident, consistent, and compliant in how we communicate science, evidence, and unmet need.

To be successful in this role, you will bring strong scientific acumen and a passion for adult learning, translating complex clinical and mechanistic concepts into clear, practical learning experiences. You will partner closely with Medical Directors and cross-functional stakeholders to develop and maintain FAQs, core talking points, objection-handling resources, and other enablement tools, and you will lead onboarding and ongoing medical training for new hires.

Reporting directly to the Executive Director, Medical Affairs, you will work within a multidisciplinary team, interfacing with Clinical Development, Scientific Communications, Commercial, Legal, Regulatory, and Compliance to ensure training content is accurate, aligned, and delivered with high quality.

This position is based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. If in the Boston area, we require a minimum of 2 days per week in the office.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking an Associate Director, Medical Training (Pipeline) to lead the strategy, development, and execution of pipeline training across our therapeutic areas (including epilepsy, major depressive disorder, and bipolar depression) and broader neuroscience portfolio. This role will build scalable, audience-tailored training programs and modules to ensure internal teams are confident, consistent, and compliant in how we communicate science, evidence, and unmet need.\n\nTo be successful in this role, you will bring strong scientific acumen and a passion for adult learning, translating complex clinical and mechanistic concepts into clear, practical learning experiences. You will partner closely with Medical Directors and cross-functional stakeholders to develop and maintain FAQs, core talking points, objection-handling resources, and other enablement tools, and you will lead onboarding and ongoing medical training for new hires.\n\nReporting directly to the Executive Director, Medical Affairs, you will work within a multidisciplinary team, interfacing with Clinical Development, Scientific Communications, Commercial, Legal, Regulatory, and Compliance to ensure training content is accurate, aligned, and delivered with high quality.\n\nThis position is based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. If in the Boston area, we require a minimum of 2 days per week in the office.\n\nRESPONSIBILITIES:\n\n - Pipeline Training Strategy: Own the end-to-end training strategy for pipeline and disease-state education (e.g., epilepsy, MDD, bipolar depression), ensuring content and curricula align to program milestones, evidence generation, and evolving scientific communications.\n\n - Training Module Development: Design and develop engaging training modules for different audiences and use-cases (field medical, sales, congress teams, cross-functional partners), incorporating adult learning principles, knowledge checks, and practical application exercises.\n\n - Onboarding & Role-Based Curricula: Lead medical/scientific onboarding for new hires who require medical training, creating role-based learning paths and ensuring readiness for compliant external engagement.\n\n - Speaker & Presentation Training: Develop and deliver speaker training (internal and external as appropriate) and presentation readiness programs, including story flow, data accuracy, appropriate use of visuals, and Q&A preparation.\n\n - FAQs, Talking Points & Objection Handling: Work with Medical Directors and Scientific Communications to develop, review, and maintain compliant FAQs, talking points, and objection-handling resources aligned to the latest medical communications platform and publication plan.\n\n - Congress & Publication Readiness: Train field and congress teams on new medical communications materials and publications (e.g., congress data disclosures, manuscripts, slide libraries), ensuring consistent interpretation and appropriate scientific exchange.\n\n - Cross-Functional Partnership: Collaborate closely with Medical Affairs, Scientific Communications, Clinical Development, Regulatory, Legal, Compliance, and Commercial partners to ensure training content is accurate, aligned, and delivered on time.\n\n - Training Delivery & Measurement: Facilitate live and virtual training sessions, manage training calendars, and assess effectiveness through feedback, knowledge checks, and continuous improvement of content and delivery methods. Lead development of certification module tests and partnering with field medical on full certification of MSLs.\n\n - Quality & Compliance: Ensure all training materials and delivery are compliant with applicable regulatory requirements and corporate standards, following required review/approval processes and maintaining version control.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n - Some international travel may be required\n\nQUALIFICATIONS:\n\n - Advanced degree in a scientific/clinical discipline (PharmD, PhD, MD, MSc, or equivalent) with 5+ years of relevant management biopharmaceutical or agency experience in Medical Affairs, Medical Education, Scientific Communications, or related functions.\n\n - Experience developing and delivering training for multiple audiences (e.g., field medical, congress teams, cross-functional stakeholders), with demonstrated ability to translate complex data into clear, practical learning.\n\n - Strong instructional design and facilitation skills (live and virtual), including building curricula, developing modules, and using feedback/metrics to continuously improve training effectiveness.\n\n - Excellent interpersonal and stakeholder management skills; ability to build credibility and partner effectively with Medical Directors, Scientific Communications, Commercial Training, and Compliance.\n\n - Demonstrated project management skills with the ability to prioritize, deliver on timelines, and manage multiple training workstreams in a fast-paced environment.\n\n - Strong written and verbal communication skills with high attention to scientific accuracy and a compliance-first mindset in content development and delivery.\n\n - Ability to travel up to 10%, as needed.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"e499c14b-23fd-4b8d-a214-255b89c5b1d2","title":"Director, Corporate Communications","department":"General & Administration","team":"Corporate Affairs","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-13T20:42:32.862+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/e499c14b-23fd-4b8d-a214-255b89c5b1d2","applyUrl":"https://jobs.ashbyhq.com/xenon/e499c14b-23fd-4b8d-a214-255b89c5b1d2/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

We are seeking a Director, Corporate Communications to join our team. The Director will be responsible for developing and executing communications strategies to promote and protect the Company's reputation, with a specific focus on Corporate, Investor, Executive and R&D communications. This leader will provide strategic execution of tactical implementation associated with corporate newsflow, including business updates, clinical trial milestones, data readouts and future product launches. This role will coordinate across internal stakeholders to deliver corporate messaging and programming to build the Xenon brand and reputation. The Director will also work to ensure external and internal communications are closely aligned to ensure teams are upholding our culture and shared values: Xenon CARES about patients, employees and those who put their trust in us.

Under the leadership of the Senior Vice President of Corporate Affairs, this role will also work with the CEO, CFO, CMO, CCO and other senior leaders to execute the Corporate and Investor Relations strategy, and effectively develop messaging and communications for our scientific, clinical, and financial progress to various stakeholder groups including investors, media and investigators. This role will work closely with the Corporate Affairs team, Executive Leadership Team, as well as the discovery, clinical development, finance, legal and commercial departments to maintain an in-depth understanding of the company’s operations, financial performance, and strategies.

This is a high-impact role ideal for a communications professional with corporate and investor communications experience who thrives in a dynamic, fast-paced biotech environment and can bridge science, strategy, and finance. The ideal candidate has significant depth of expertise in understanding of business strategies and executive priorities and is a critical thinker with strong problem-solving skills. The ideal candidate is also a strong communicator who collaborates effectively with key functions to communicate the corporate story. Reporting to the Executive Director of Corporate Communications, this position will be part of the Corporate Affairs team and located in our Boston location, in Needham, MA, USA.

RESPONSIBILITIES:

Corporate, investor, executive and R&D communications

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\n\n\nWe are seeking a Director, Corporate Communications to join our team. The Director will be responsible for developing and executing communications strategies to promote and protect the Company's reputation, with a specific focus on Corporate, Investor, Executive and R&D communications. This leader will provide strategic execution of tactical implementation associated with corporate newsflow, including business updates, clinical trial milestones, data readouts and future product launches. This role will coordinate across internal stakeholders to deliver corporate messaging and programming to build the Xenon brand and reputation. The Director will also work to ensure external and internal communications are closely aligned to ensure teams are upholding our culture and shared values: Xenon CARES about patients, employees and those who put their trust in us.\n\n\n\nUnder the leadership of the Senior Vice President of Corporate Affairs, this role will also work with the CEO, CFO, CMO, CCO and other senior leaders to execute the Corporate and Investor Relations strategy, and effectively develop messaging and communications for our scientific, clinical, and financial progress to various stakeholder groups including investors, media and investigators. This role will work closely with the Corporate Affairs team, Executive Leadership Team, as well as the discovery, clinical development, finance, legal and commercial departments to maintain an in-depth understanding of the company’s operations, financial performance, and strategies.\n\n\n\nThis is a high-impact role ideal for a communications professional with corporate and investor communications experience who thrives in a dynamic, fast-paced biotech environment and can bridge science, strategy, and finance. The ideal candidate has significant depth of expertise in understanding of business strategies and executive priorities and is a critical thinker with strong problem-solving skills. The ideal candidate is also a strong communicator who collaborates effectively with key functions to communicate the corporate story. Reporting to the Executive Director of Corporate Communications, this position will be part of the Corporate Affairs team and located in our Boston location, in Needham, MA, USA.\n\n\n\nRESPONSIBILITIES:\n\nCorporate, investor, executive and R&D communications\n\n - Increase awareness and visibility of Xenon’s emerging leadership in epilepsy and neuropsychiatry, growing pain portfolio, and emergence as a leading biopharma company soon to be a fully integration commercial organization\n\n - Lead development of corporate messaging and materials, including press releases, Q&As, corporate presentations, executive talking points, social media content, etc., in collaboration with Corporate Affairs, Brand Communications, the CFO, CEO, Medical Affairs, Clinical Development, Commercial, Legal, Regulatory, and other parts of the organization.\n\n - Build strategies around and execute programming for corporate stakeholders including investors, media, investigators, partners and policymakers/influencers.\n\n - Collaborate with the CFO, CEO, Corporate Affairs and Executive Leadership team to craft clear, consistent messaging around company strategy, pipeline, and milestones.\n\n - Lead development of briefing materials for management in preparation for investor meetings.\n\n - Lead the discussions and development of IR/Industry conference presentations, panels/Q&As, PRs, through collaboration with subject matter experts and leaders across the organization, as well as materials reviews.\n\n - Drive and support preparation of earnings calls, press releases, and SEC filings (10-K, 10-Q, 8-K) in coordination with Finance and Legal.\n\n - Maintain Xenon’s Investor Relations website, including ongoing maintenance and content updates as needed in collaboration with the website vendor.\n\n - Work with Competitive Intelligence and other leaders across the company to monitor competitors’ performance -- along with industry, regulatory, and other relevant trends -- to inform differentiated corporate messaging.\n\n - Increase executive visibility and thought leadership via conference participation, thought leadership, panels and industry awards for the Executive Leadership Team and develop supporting external executive communications strategies and materials.\n\n - Work closely with the discovery and clinical teams on the emerging R&D portfolio and work, including developing external communications strategies and plans related to key milestones, how we will communicate to investors and other external stakeholders.\n\n - Support internal and external investigator communications by working closely with the R&D teams.\n\n - Partner with Corporate Affairs and Legal teams to ensure all external communications are accurate and consistent with corporate messaging including presentation decks, news releases, and all other content.\n\n - Manage the review process of external corporate materials.\n\n - Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n - Travel will be required up to 15% both domestically and internationally.\n\n - Other duties as required.\n\n\n\nQUALIFICATIONS:\n\n - Bachelor’s degree or equivalent, ideally with a specialization in Finance, Business, Life Sciences, or Communications; master’s or advanced degree preferred.\n\n - Biotech or pharma industry experience is required; 10+ years of investor relations experience, ideally in the healthcare sector.\n\n - Strong communications expertise, including written, verbal, presentation, interpersonal skills, with the ability to translate and simplify complex scientific information and clinical data for research analysts and investors.\n\n - Proven track record of developing corporate and investor communication messaging and materials.\n\n - Experience developing executive level communications and engaging directly with senior management.\n\n - Superior interpersonal and external and internal customer relationship management skills.\n\n - Comprehensive understanding of the biotech industry, drug development and commercialization.\n\n - Issues management experience with a track record of successfully planning for and publicly addressing high profile business topics with key external stakeholders.\n\n - Highly organized, with attention to detail, adherence to deadlines, and ability to work under pressure with multiple, shifting priorities.\n\n - Comfortable operating in an agile environment but also possess solid experience successfully navigating the complexities of a growing organization.\n\n - Ability to build and retain in-depth knowledge of a company, business strategies & objectives to be able to develop innovative concepts that will work in the organization, and then effectively communicate and promote new ideas to ensure organizational buy-in.\n\n - Can consistently work with abstract ideas or situations across functional areas of the business, then through assessment of variables and assumptions, can identify strategies and solutions.\n\n - Can build effective, trusted relationships and influence without authority - has the confidence and ability to interact with executive level management and various functions (regardless of level of responsibility) and can navigate extremely critical matters.\n\n - Can effectively interact with all functions, teams, independent contributors, contractors, agency partners and vendors in gaining consensus, developing strategies, or executing a program.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"882cb7a9-3a73-4e50-99d5-68db4042498c","title":"National Account Director - East Region","department":"Commercial","team":"Market Access","employmentType":"FullTime","location":"United States","secondaryLocations":[],"publishedAt":"2026-08-13T18:07:00.638+00:00","isListed":true,"isRemote":true,"workplaceType":"Remote","address":{"postalAddress":{"addressCountry":"United States"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/882cb7a9-3a73-4e50-99d5-68db4042498c","applyUrl":"https://jobs.ashbyhq.com/xenon/882cb7a9-3a73-4e50-99d5-68db4042498c/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

The National Account Director - East Region, will play a critical leadership role in shaping and executing our U.S. market access strategy with national and large regional commercial payers in preparation for our first launch of Azetukalner in epilepsy. This is a critical, field-based role responsible for building relationships with targeted customers, communicating our value proposition and securing favorable access to minimize hurdles for the patients we serve. We are seeking individuals that are strategic thinkers who thrive in a fast-paced, startup environment, and can contribute across the organization for success.

This position reports to the Senior Director, Payer Accounts and will be fully remote. This person will be responsible for the East region. The level of the position will be commensurate with the candidate’s education and industry experience.

RESPONSIBILITIES:

•\tEnsure Xenon’s products are quickly reviewed post approval to ensure rapid formulary adoption enabling patient access that is equal to branded products in relative categories Xenon competes in:

Account Expertise & Knowledge

•\tEstablish and maintain multiple touch points at strategic payer accounts, including senior executives, to communicate the Xenon payer value story

•\tNavigate payer organizations to build long-term relationships with key decision makers and potential influencers paving the way for the pipeline of innovative products from Xenon

•\tHave complete understanding of the complex payer organizations and different wholly owned subsidiaries who may have services and programs that impact the Epilepsy class. Monitor to assess opportunities for partnerships long term

•\tPrioritize top accounts using data and personal intelligence

Securing Coverage & Access

•\tSecure access and coverage rapidly for all Xenon products that is at parity with key competitors in respective classes

•\tDevelop strategic business plans by account

•\tSecure appropriate coverage and formulary positioning in alignment with Commercial goals working collaboratively with Medical Affairs and Value and Access to ensure the value proposition and HEOR data is appropriately communicated to target audiences

•\tEvaluate contracting opportunities that are consistent with Xenon’s goals. Lead the contract process from initiation to negotiation/completion. Manage ongoing contracts with quarterly business reviews and evaluate ROI

Collaboration and Communication

•\tReview data (sales trends, competitive landscape by local market) to identify pull-through opportunities. Work with regional sales directors and sales representatives to address access challenges and maximize success by executing aligned pull-through plans.

•\tAssist in field training on access and reimbursement

•\tDeliver payer insights back to market access, medical affairs, and patient services as appropriate.

•\tRepresent Xenon at Key Industry Conferences (e.g., AMCP, Asembia, PCMA)

•\tDevelop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans

•\tPlan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies

•\tRecruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices

•\tAct in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any

•\tSome international travel may be required

•\tOther duties as assigned

QUALIFICATIONS:

•\tMinimum of a bachelor's degree required; advanced degree a plus

•\tMinimum of 10-12 years of market access experience, in biotech pharmaceuticals with at least 5 years calling on national accounts

•\tIn-depth knowledge of payer/PBM economics: understanding key issues and how these shift given changing US healthcare landscape

•\tClear understanding of analytics: ability to apply analytical insight to drive account performance and ability to “ask the right questions” of analytical resources

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nThe National Account Director - East Region, will play a critical leadership role in shaping and executing our U.S. market access strategy with national and large regional commercial payers in preparation for our first launch of Azetukalner in epilepsy. This is a critical, field-based role responsible for building relationships with targeted customers, communicating our value proposition and securing favorable access to minimize hurdles for the patients we serve. We are seeking individuals that are strategic thinkers who thrive in a fast-paced, startup environment, and can contribute across the organization for success.\n\nThis position reports to the Senior Director, Payer Accounts and will be fully remote. This person will be responsible for the East region. The level of the position will be commensurate with the candidate’s education and industry experience.\n\nRESPONSIBILITIES:\n\n• Ensure Xenon’s products are quickly reviewed post approval to ensure rapid formulary adoption enabling patient access that is equal to branded products in relative categories Xenon competes in:\n\nAccount Expertise & Knowledge\n\n• Establish and maintain multiple touch points at strategic payer accounts, including senior executives, to communicate the Xenon payer value story\n\n• Navigate payer organizations to build long-term relationships with key decision makers and potential influencers paving the way for the pipeline of innovative products from Xenon\n\n• Have complete understanding of the complex payer organizations and different wholly owned subsidiaries who may have services and programs that impact the Epilepsy class. Monitor to assess opportunities for partnerships long term\n\n• Prioritize top accounts using data and personal intelligence\n\nSecuring Coverage & Access\n\n• Secure access and coverage rapidly for all Xenon products that is at parity with key competitors in respective classes\n\n• Develop strategic business plans by account \n\n• Secure appropriate coverage and formulary positioning in alignment with Commercial goals working collaboratively with Medical Affairs and Value and Access to ensure the value proposition and HEOR data is appropriately communicated to target audiences\n\n• Evaluate contracting opportunities that are consistent with Xenon’s goals. Lead the contract process from initiation to negotiation/completion. Manage ongoing contracts with quarterly business reviews and evaluate ROI\n\nCollaboration and Communication\n\n• Review data (sales trends, competitive landscape by local market) to identify pull-through opportunities. Work with regional sales directors and sales representatives to address access challenges and maximize success by executing aligned pull-through plans.\n\n• Assist in field training on access and reimbursement\n\n• Deliver payer insights back to market access, medical affairs, and patient services as appropriate.\n\n• Represent Xenon at Key Industry Conferences (e.g., AMCP, Asembia, PCMA)\n\n• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans\n\n• Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies\n\n• Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices\n\n• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n• Some international travel may be required\n\n• Other duties as assigned\n\nQUALIFICATIONS:\n\n• Minimum of a bachelor's degree required; advanced degree a plus \n\n• Minimum of 10-12 years of market access experience, in biotech pharmaceuticals with at least 5 years calling on national accounts \n\n• In-depth knowledge of payer/PBM economics: understanding key issues and how these shift given changing US healthcare landscape \n\n• Clear understanding of analytics: ability to apply analytical insight to drive account performance and ability to “ask the right questions” of analytical resources\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"dd1d07b9-9f5e-43d8-8231-fd9fcee15514","title":"Director, HCP Marketing","department":"Commercial","team":"Marketing","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-13T18:06:18.205+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/dd1d07b9-9f5e-43d8-8231-fd9fcee15514","applyUrl":"https://jobs.ashbyhq.com/xenon/dd1d07b9-9f5e-43d8-8231-fd9fcee15514/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

The Director, HCP Marketing, will lead the development and execution of HCP education strategy to support brand objectives and drive appropriate product adoption across the US market. This role sits within US HCP Marketing and is responsible for delivering high-impact, compliant educational initiatives that improve disease understanding, clinical practice, and confidence in product use.

This individual will serve as a strategic partner during launch and pre-launch, ensuring education programs are insight-driven, differentiated, and tightly aligned with brand strategy and customer experience priorities.

This role is critical to shaping how healthcare providers understand, adopt, and ultimately deliver innovative therapies to patients. The Director will play a pivotal role in ensuring education is not only scientifically rigorous but also strategically differentiated—driving meaningful impact for both patients and the brand.

This position reports to the Senior Director, HCP Marketing, and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

HCP Education Strategy (Brand & Launch Focus)

Program Design & Execution

Cross-Functional Integration

KOL & Stakeholder Engagement

Launch Excellence

Agency, Budget & Vendor Management

Performance & Analytics

ADDITIONAL RESPONSIBILTIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nThe Director, HCP Marketing, will lead the development and execution of HCP education strategy to support brand objectives and drive appropriate product adoption across the US market. This role sits within US HCP Marketing and is responsible for delivering high-impact, compliant educational initiatives that improve disease understanding, clinical practice, and confidence in product use.\n\nThis individual will serve as a strategic partner during launch and pre-launch, ensuring education programs are insight-driven, differentiated, and tightly aligned with brand strategy and customer experience priorities.\n\nThis role is critical to shaping how healthcare providers understand, adopt, and ultimately deliver innovative therapies to patients. The Director will play a pivotal role in ensuring education is not only scientifically rigorous but also strategically differentiated—driving meaningful impact for both patients and the brand.\n\nThis position reports to the Senior Director, HCP Marketing, and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. Hybrid positions require a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\nHCP Education Strategy (Brand & Launch Focus)\n\n - Lead the development of the US HCP education strategy aligned to brand goals, lifecycle stage (including launch-readiness), and key customer segments.\n\n - Translate brand strategy, positioning, and customer insights into actionable, differentiated education plans.\n\n - Identify priority HCP segments (specialists, community providers, advanced practice providers, etc.) and tailor education approaches accordingly.\n\n - Serve as the education lead in brand planning, ensuring strong integration across omnichannel touchpoints.\n\nProgram Design & Execution\n\n - Oversee the design and execution of HCP education programs, including:\n\n - Peer-to-peer programs and speaker bureaus\n\n - Congress strategy and educational presence\n\n - Workshops, advisory boards, and training events\n\n - Digital and on-demand learning platforms\n\n - Develop compelling, insight-driven educational content aligned to clinical data and brand narrative.\n\n - Ensure consistent and differentiated HCP experience across channels and programs.\n\nCross-Functional Integration\n\n - Act as a central integrator across Marketing, Customer Engagement, Medical Affairs, Field Sales, Market Access, and Customer Experience teams.\n\n - Partner closely with:\n\n - Brand leads on strategy and messaging\n\n - Medical Affairs on scientific accuracy and non-promotional education\n\n - Field teams to enable execution and feedback loops\n\n - Align with regulatory, legal, and compliance partners to ensure all programming meets internal and external standards.\n\nKOL & Stakeholder Engagement\n\n - Build and manage relationships with key opinion leaders (KOLs), faculty, and professional societies.\n\n - Lead faculty development, speaker training, and advisory board planning.\n\n - Ensure KOL insights are incorporated into education strategy and content development.\n\nLaunch Excellence\n\n - Support pre-launch readiness by:\n\n - Mapping educational gaps and opportunities\n\n - Building foundational disease-state education\n\n - Developing launch-phase HCP onboarding and training strategies\n\n - Ensure education programs accelerate awareness, diagnosis, and appropriate treatment in early launch phases.\n\nAgency, Budget & Vendor Management\n\n - Manage and lead external agency partners and vendors\n\n - Own professional education marketing budget, ensuring effective resource allocation\n\n - Ensure all activities adhere to regulatory, legal, and promotional review requirements\n\nPerformance & Analytics\n\n - Define KPIs and success metrics (engagement, reach, behavior change, impact on brand performance).\n\n - Leverage data and insights to continuously optimize education strategy and investment.\n\n - Manage education budget and vendor partnerships effectively\n\nADDITIONAL RESPONSIBILTIES:\n\n - Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans\n\n - Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies\n\n - Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n - Some international travel may be required\n\n - Other duties as assigned\n\nQUALIFICATIONS:\n\n - Bachelor’s degree required; advanced degree preferred\n\n - 10+ years of relevant management experience or combination of degrees and experience including 3–5+ years in HCP marketing, professional education, or medical education roles\n\n - Proven experience supporting product launches or major brand milestones\n\n - Strong cross-functional leadership in a matrixed environment\n\n - Deep expertise in HCP engagement and education strategy\n\n - Strong brand and commercial acumen (especially in launch environments)\n\n - Understanding of compliance and regulatory requirements (FDA, PhRMA, ACCME as applicable)\n\n - Exceptional communication, storytelling, and influence skills\n\n - Data-driven decision-making and performance tracking\n\n - Ability to manage multiple priorities in a fast-paced environment\n\n - Ability to travel up to 25–40% (congresses, field engagement, training programs)\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"02273d33-05dc-4346-9543-2b312d8a48be","title":"Director, Revenue Accounting","department":"General & Administration","team":"Finance","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-19T19:12:40.292+00:00","isListed":true,"isRemote":false,"workplaceType":"OnSite","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/02273d33-05dc-4346-9543-2b312d8a48be","applyUrl":"https://jobs.ashbyhq.com/xenon/02273d33-05dc-4346-9543-2b312d8a48be/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Director, Revenue Accounting to join our team. This role will be a key member of the Finance department and will play a crucial role for revenue recognition and Gross‑to‑Net (GTN) accounting under ASC 606, while collaborating with key stakeholders in the Commercial organization.

The Director will establish scalable commercial accounting infrastructure, oversee pricing and top‑line analytics, support revenue guidance, and ensure SOX‑compliant controls as Xenon transitions from an R&D‑centric to a commercial‑centric company. This role partners cross‑functionally to deliver accurate revenue reporting, robust forecasting, and clear executive‑level insights into business performance and value drivers.

This role reports to the VP, Finance and is based out of Boston, MA, USA, in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Director, Revenue Accounting to join our team. This role will be a key member of the Finance department and will play a crucial role for revenue recognition and Gross‑to‑Net (GTN) accounting under ASC 606, while collaborating with key stakeholders in the Commercial organization.\n\nThe Director will establish scalable commercial accounting infrastructure, oversee pricing and top‑line analytics, support revenue guidance, and ensure SOX‑compliant controls as Xenon transitions from an R&D‑centric to a commercial‑centric company. This role partners cross‑functionally to deliver accurate revenue reporting, robust forecasting, and clear executive‑level insights into business performance and value drivers.\n\nThis role reports to the VP, Finance and is based out of Boston, MA, USA, in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.\n\n\n\nRESPONSIBILITIES:\n\n - Design, implement, and maintain GTN reserve methodologies, including documentation of reasonable assumptions: commercial and government rebates, chargebacks, copay and patient assistance programs, distribution service fees, returns and other variable considerations\n\n - Responsible for monthly close processes for revenue and GTN, including journal entries, account reconciliations, true‑ups, and variance analysis\n\n - Manage the quarterly GTN forecasting process by ensuring alignment between Commercial revenue forecast and guidance and report against such guidance, including analysis of pricing actions, margin dynamics, and market trends\n\n - Manage government pricing reporting and state price transparency reporting with internal stakeholders and outsourced vendor(s), and ensure appropriate compliance with regulatory requirements\n\n - Work within finance systems to implement or enhance systems to address planning and reporting needs of commercial accounting and GTN processes\n\n - Establish and maintain scalable data flows with 3PLs and other parties; review data provided by external parties for completeness, accuracy, and reasonable\n\n - Build SOX‑compliant internal controls, policies, and SOPs in preparation for commercial launch and first audit cycles.\n\n - Serve as the primary commercial accounting contact for external auditors\n\n - Prepare analysis, commentary, and presentation materials for monthly and quarterly financial reviews, including executive leadership and Board of Directors meetings\n\n - Partner with Commercial team on pricing strategy and other strategic analysis as required\n\n - Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports\n\n - Other duties as assigned\n \n \n\nQUALIFICATIONS:\n\n - Professional designation (CPA or equivalent) is required, technical training with Big Four CPA firm or large regional CPA firm preferred\n\n - 10+ years of progressive finance and/or accounting experience with significant biotech or pharmaceutical commercial exposure\n\n - Demonstrated experience supporting at least one successful first commercial product launch and experience with designing commercial accounting processes under US GAAP and SOX environment\n\n - Strong expertise in Gross-to-Net accounting, revenue recognition, and government pricing\n\n - Strong knowledge of U.S. pharmaceutical distribution models, including specialty pharmacy, specialty distributor, 3PL, PBMs, GPOs, patient support programs, and 340B\n\n - Experience in ERP implementations or financial systems transformation initiatives; experience with Oracle Fusion and Adaptive Planning is a bonus\n\n - Proven experience building strong relationships with internal stakeholders and external service providers\n\n - Excellent organizational skills and the ability to manage concurrent deliverables and work effectively in a challenging, high performance, team environment\n\n - Exceptional interpersonal and communication skills (written and oral); communicates in a clear, concise and organized manner; listens and works collaboratively with others outside of Finance to obtain information\n\n - Able to think and act strategically, anticipate road-blocks and map out next steps in support of a fast-growing company\n\n - Self-motivated, with initiative and the ability to take ownership of, and drive projects from start to finish\n\n - Demonstrated high level of integrity and ethics\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"494f7ba0-bbfc-4c23-a2e7-793da6c20775","title":"Director, Field Effectiveness & Operations","department":"Commercial","team":"Commercial Operations","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-13T18:07:44.351+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/494f7ba0-bbfc-4c23-a2e7-793da6c20775","applyUrl":"https://jobs.ashbyhq.com/xenon/494f7ba0-bbfc-4c23-a2e7-793da6c20775/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Director, Field Effectiveness & Operations, to develop and operate a high-performing commercial field operations function in support of Xenon’s first anticipated product launch in epilepsy.

The ideal candidate is a hands-on builder with strong field operations, commercial operations, CRM, field analytics, incentive compensation, targeting, and launch-readiness experience. This person should be comfortable operating in a lean, fast-paced biotech environment, translating strategy into scalable execution, and using data, automation, and AI-enabled capabilities to improve launch performance, field productivity, and leadership decision-making.

This role will serve as the operational engine for field readiness, field execution, and launch performance optimization across customer-facing commercial teams. The Director will partner closely with Field Strategy, Marketing, Market Access, Medical Affairs, Commercial Analytics, IT, Finance, HR, Legal, Compliance, and external vendors to ensure that cross-functional field teams are equipped with the right infrastructure, tools, processes, insights, and operational partnership to execute effectively and compliantly. This role will also partner on development and implementation of AI strategy to accelerate and optimize launch.

This position reports to the Vice President, Commercial Operations, and will be based out of Boston, MA, USA in our Needham office. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

Field Effectiveness Strategy & Launch Readiness

•\tBuild and operationalize Xenon’s field effectiveness infrastructure to support launch readiness, launch execution, and post-launch optimization across commercial field teams

•\tPartner with Field Strategy, Marketing, Market Access, Medical, Data Strategy & Analytics, IT, Finance, HR, Legal, and Compliance to translate launch strategy into field-ready processes, tools, and operating rhythms

•\tServe as a primary Commercial Operations partner to field strategy and leadership, ensuring field execution needs are anticipated, prioritized, and translated into operational and scalable solutions.

•\tDevelop and produce field execution analytics and identify gaps in execution quality, adoption, and performance variability

Territory Alignment, Targeting & Field Deployment Operations

•\tCollaborate on strategy and lead operational execution of territory alignment, targeting refinement, field deployment support, and related vendor workstreams in partnership with Commercial Analytics, Sales leadership, Market Access, IT, and external partners

•\tOwn targeting operations and refinement processes, ensuring targeting outputs are accurate, actionable, timely, and aligned to commercial strategy. Collaborate on applicable targeting strategy using dynamic or hybrid data products

•\tTranslate field design, account segmentation, and targeting logic into field-ready CRM workflows, call plans, execution guidance, and KPIs

CRM, Field Technology & Operational Enablement

•\tServe as the business owner or key Commercial Operations partner for field-facing systems and tools, including CRM, field reporting, account planning tools, dashboards, and related technology platforms

•\tCollaborate on business requirements for CRM workflows, field reporting, dashboards, account planning tools, and other field enablement capabilities

Incentive Compensation & Performance Operations

•\tLead incentive compensation operations in partnership with Sales leadership, Finance, HR, Legal, Compliance, and Analytics

•\tDevelop and lead IC governance, plan operations, goal-setting inputs, payout operations, issue resolution, documentation, and field communications

•\tSupport leadership decision-making by providing clear operational insights on IC effectiveness, field behavior, execution quality, and launch performance signals

AI, Automation & Innovation in Field Effectiveness

•\tIdentify, develop, and implement AI-enabled and automation-based solutions that improve field productivity, launch performance, and leadership decision-making

•\tPartner with Commercial Analytics, Data Strategy, IT, Legal, Compliance, Privacy, and business stakeholders to evaluate appropriate AI use cases across field operations and commercial execution

Cross-Functional Partnership

•\tPartner closely with the Senior Director, Field Strategy & Enablement and commercial training team to ensure training materials, onboarding, and launch readiness programs incorporate relevant systems, processes, data, dashboards, CRM workflows, targeting, IC, and operational expectations

•\tManage external vendors supporting field operations, CRM, targeting, IC, dashboards, credentialing, field technology, or related workstreams

•\tTeam Leadership & Functional Build

•\tManage and develop direct reports and/or contractors over time, including potential roles focused on incentive compensation, field operations, and field effectiveness

•\tOperate effectively as both a strategic leader and hands-on builder in a lean, pre-launch / launch-stage biotech environment

ADDITONAL RESPONSIBILITES:

•\tDevelop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans

•\tPlan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies

•\tRecruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices

•\tAct in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any

•\tSome international travel may be required

•\tOther duties as assigned

QUALIFICATIONS:

Required

•\tBachelor’s degree required; advanced degree in business, life sciences, analytics, healthcare, or related field preferred

•\t10+ years of progressive experience in pharmaceutical, biotech, or life sciences commercial operations, sales operations, field effectiveness, sales force effectiveness, field analytics, or related roles

•\tDemonstrated experience supporting launch readiness or commercial launch execution, ideally in a specialty, rare disease, neurology, CNS, or complex market environment

•\tStrong knowledge of field operations capabilities, including CRM, territory alignment, targeting, field deployment, call planning, incentive compensation, field reporting, and performance management

•\tExperience partnering with Sales, Marketing, Market Access, Medical Affairs, Analytics, IT, Finance, HR, Legal, Compliance, and external vendors

•\tDemonstrated ability to translate commercial strategy into scalable operational processes, tools, dashboards, and execution plans

•\tStrong understanding of field-facing technology platforms, CRM workflows, business requirements, data quality, and reporting adoption

•\tStrong analytical orientation with the ability to interpret field performance, identify execution gaps, and communicate actionable recommendations to senior leaders

•\tPractical understanding of pharmaceutical compliance considerations related to field operations, CRM, data capture, incentive compensation, and field communications

•\tExcellent project management, cross-functional leadership, executive communication, and stakeholder management skills

•\tAbility to thrive in a fast-paced, evolving, build-mode environment with high ambiguity and competing priorities

Preferred

•\tExperience with Veeva CRM, Salesforce, Power BI, Tableau, Snowflake, IQVIA, Symphony, claims data, specialty pharmacy data, hub/patient services data, or related commercial data assets

•\tExperience designing or operationalizing incentive compensation plans, field force alignment models, call planning, field dashboards, account planning tools, or QBR processes

•\tExperience with AI, machine learning, automation, or advanced analytics use cases in commercial operations, field effectiveness, omnichannel execution, or launch performance management

•\tExperience supporting field teams across sales, access, medical, account management, or other customer-facing commercial functions

•\tExperience in epilepsy, neurology, CNS, rare disease, specialty pharmacy, or high-science specialty markets

•\tPrior experience building a function or capability from the ground up in a small or mid-sized biotech environment

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role: \n\nWe are seeking a Director, Field Effectiveness & Operations, to develop and operate a high-performing commercial field operations function in support of Xenon’s first anticipated product launch in epilepsy.\n\nThe ideal candidate is a hands-on builder with strong field operations, commercial operations, CRM, field analytics, incentive compensation, targeting, and launch-readiness experience. This person should be comfortable operating in a lean, fast-paced biotech environment, translating strategy into scalable execution, and using data, automation, and AI-enabled capabilities to improve launch performance, field productivity, and leadership decision-making.\n\nThis role will serve as the operational engine for field readiness, field execution, and launch performance optimization across customer-facing commercial teams. The Director will partner closely with Field Strategy, Marketing, Market Access, Medical Affairs, Commercial Analytics, IT, Finance, HR, Legal, Compliance, and external vendors to ensure that cross-functional field teams are equipped with the right infrastructure, tools, processes, insights, and operational partnership to execute effectively and compliantly. This role will also partner on development and implementation of AI strategy to accelerate and optimize launch. \n\nThis position reports to the Vice President, Commercial Operations, and will be based out of Boston, MA, USA in our Needham office. Hybrid positions require a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\n Field Effectiveness Strategy & Launch Readiness\n\n• Build and operationalize Xenon’s field effectiveness infrastructure to support launch readiness, launch execution, and post-launch optimization across commercial field teams\n\n• Partner with Field Strategy, Marketing, Market Access, Medical, Data Strategy & Analytics, IT, Finance, HR, Legal, and Compliance to translate launch strategy into field-ready processes, tools, and operating rhythms\n\n• Serve as a primary Commercial Operations partner to field strategy and leadership, ensuring field execution needs are anticipated, prioritized, and translated into operational and scalable solutions.\n\n• Develop and produce field execution analytics and identify gaps in execution quality, adoption, and performance variability\n\nTerritory Alignment, Targeting & Field Deployment Operations\n\n• Collaborate on strategy and lead operational execution of territory alignment, targeting refinement, field deployment support, and related vendor workstreams in partnership with Commercial Analytics, Sales leadership, Market Access, IT, and external partners\n\n• Own targeting operations and refinement processes, ensuring targeting outputs are accurate, actionable, timely, and aligned to commercial strategy. Collaborate on applicable targeting strategy using dynamic or hybrid data products \n\n• Translate field design, account segmentation, and targeting logic into field-ready CRM workflows, call plans, execution guidance, and KPIs\n\nCRM, Field Technology & Operational Enablement\n\n• Serve as the business owner or key Commercial Operations partner for field-facing systems and tools, including CRM, field reporting, account planning tools, dashboards, and related technology platforms\n\n• Collaborate on business requirements for CRM workflows, field reporting, dashboards, account planning tools, and other field enablement capabilities\n\nIncentive Compensation & Performance Operations\n\n• Lead incentive compensation operations in partnership with Sales leadership, Finance, HR, Legal, Compliance, and Analytics\n\n• Develop and lead IC governance, plan operations, goal-setting inputs, payout operations, issue resolution, documentation, and field communications\n\n• Support leadership decision-making by providing clear operational insights on IC effectiveness, field behavior, execution quality, and launch performance signals\n\nAI, Automation & Innovation in Field Effectiveness\n\n• Identify, develop, and implement AI-enabled and automation-based solutions that improve field productivity, launch performance, and leadership decision-making\n\n• Partner with Commercial Analytics, Data Strategy, IT, Legal, Compliance, Privacy, and business stakeholders to evaluate appropriate AI use cases across field operations and commercial execution\n\nCross-Functional Partnership \n\n• Partner closely with the Senior Director, Field Strategy & Enablement and commercial training team to ensure training materials, onboarding, and launch readiness programs incorporate relevant systems, processes, data, dashboards, CRM workflows, targeting, IC, and operational expectations \n\n• Manage external vendors supporting field operations, CRM, targeting, IC, dashboards, credentialing, field technology, or related workstreams\n\n• Team Leadership & Functional Build\n\n• Manage and develop direct reports and/or contractors over time, including potential roles focused on incentive compensation, field operations, and field effectiveness\n\n• Operate effectively as both a strategic leader and hands-on builder in a lean, pre-launch / launch-stage biotech environment\n\nADDITONAL RESPONSIBILITES:\n\n• Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans\n\n• Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies\n\n• Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices\n\n• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n• Some international travel may be required\n\n• Other duties as assigned\n\nQUALIFICATIONS:\n\nRequired\n\n• Bachelor’s degree required; advanced degree in business, life sciences, analytics, healthcare, or related field preferred\n\n• 10+ years of progressive experience in pharmaceutical, biotech, or life sciences commercial operations, sales operations, field effectiveness, sales force effectiveness, field analytics, or related roles\n\n• Demonstrated experience supporting launch readiness or commercial launch execution, ideally in a specialty, rare disease, neurology, CNS, or complex market environment\n\n• Strong knowledge of field operations capabilities, including CRM, territory alignment, targeting, field deployment, call planning, incentive compensation, field reporting, and performance management\n\n• Experience partnering with Sales, Marketing, Market Access, Medical Affairs, Analytics, IT, Finance, HR, Legal, Compliance, and external vendors\n\n• Demonstrated ability to translate commercial strategy into scalable operational processes, tools, dashboards, and execution plans\n\n• Strong understanding of field-facing technology platforms, CRM workflows, business requirements, data quality, and reporting adoption\n\n• Strong analytical orientation with the ability to interpret field performance, identify execution gaps, and communicate actionable recommendations to senior leaders\n\n• Practical understanding of pharmaceutical compliance considerations related to field operations, CRM, data capture, incentive compensation, and field communications\n\n• Excellent project management, cross-functional leadership, executive communication, and stakeholder management skills\n\n• Ability to thrive in a fast-paced, evolving, build-mode environment with high ambiguity and competing priorities\n\nPreferred\n\n• Experience with Veeva CRM, Salesforce, Power BI, Tableau, Snowflake, IQVIA, Symphony, claims data, specialty pharmacy data, hub/patient services data, or related commercial data assets\n\n• Experience designing or operationalizing incentive compensation plans, field force alignment models, call planning, field dashboards, account planning tools, or QBR processes\n\n• Experience with AI, machine learning, automation, or advanced analytics use cases in commercial operations, field effectiveness, omnichannel execution, or launch performance management\n\n• Experience supporting field teams across sales, access, medical, account management, or other customer-facing commercial functions\n\n• Experience in epilepsy, neurology, CNS, rare disease, specialty pharmacy, or high-science specialty markets\n\n• Prior experience building a function or capability from the ground up in a small or mid-sized biotech environment\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"d1869033-70a7-4ee7-ac60-9b51caabcb37","title":"Senior Medical Director, Clinical Development (Psychiatry)","department":"Clinical Development","team":"Clinical Development","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-06T00:08:47.698+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/d1869033-70a7-4ee7-ac60-9b51caabcb37","applyUrl":"https://jobs.ashbyhq.com/xenon/d1869033-70a7-4ee7-ac60-9b51caabcb37/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Senior Medical Director, Clinical Development to join our team. This incumbent is a key contributor to clinical development of the Company’s portfolio of products and product candidates from Discovery to Phase 3 and post-approval activities, focusing on leadership of clinical studies and programs as required, medical leadership, medical and safety monitoring (as Medical Monitor) for assigned company’s products. The Senior Medical Director, Clinical Development will have medical knowledge of psychiatry and preferably neurology, recent development advances in psychiatric therapeutics landscape, relevant drug development experience, be a collaborative, inspirational, resilient leader, have a broad strategic view of therapeutic area and be well-versed in high quality trial execution. Ability for highly collaborative approach to working with others across a range of Discovery, Clinical Development, and Commercial functions is an expectation. The Senior Medical Director, Clinical Development will interact with all levels of internal staff as well as external stakeholders, including, but not limited to Key Opinion Leaders, Advisory Boards and Committees, and Health Authorities.

This position reports to the Vice President, Clinical Development, Psychiatry and will have flexibility to be based out of Boston, MA or remote locations. Boston based candidates will require a minimum of two onsite days per week.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Senior Medical Director, Clinical Development to join our team. This incumbent is a key contributor to clinical development of the Company’s portfolio of products and product candidates from Discovery to Phase 3 and post-approval activities, focusing on leadership of clinical studies and programs as required, medical leadership, medical and safety monitoring (as Medical Monitor) for assigned company’s products. The Senior Medical Director, Clinical Development will have medical knowledge of psychiatry and preferably neurology, recent development advances in psychiatric therapeutics landscape, relevant drug development experience, be a collaborative, inspirational, resilient leader, have a broad strategic view of therapeutic area and be well-versed in high quality trial execution. Ability for highly collaborative approach to working with others across a range of Discovery, Clinical Development, and Commercial functions is an expectation. The Senior Medical Director, Clinical Development will interact with all levels of internal staff as well as external stakeholders, including, but not limited to Key Opinion Leaders, Advisory Boards and Committees, and Health Authorities.\n\nThis position reports to the Vice President, Clinical Development, Psychiatry and will have flexibility to be based out of Boston, MA or remote locations. Boston based candidates will require a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\n - Lead and manage clinical development studies in psychiatry, primarily in major depressive disorder (MDD) including design and medical oversight throughout clinical development stages in collaboration with internal colleagues.\n\n - Ability to serves as medical monitor (MM) and interact collaboratively, collegially and competently with clinical research sites and investigators globally, to represent the Company, Product and protocol in the most optimal manner.\n\n - Contribute to the preparation and on-going revisions and strategy of Clinical Development Plans for assigned products and product candidates, collaborating with other key internal functions including Translational Drug Development, Biostatistics, Clinical Operations, Regulatory, Medical Affairs and Commercial.\n\n - Provide strategic and scientific leadership for trial designs, both standard and novel for both large and rare disease indications.\n\n - Review scientific literature and develop product and indication knowledge to understand and effectively communicate information relating to products, product candidates and therapeutic areas.\n\n - Serve as therapeutic area expert to provide scientific input into the development, execution, and communication of clinical trial(s).\n\n - Maintain a high degree of awareness of the external research and regulatory environments and track emerging study data to ensure appropriateness of clinical development plans and trial endpoints.\n\n - In collaboration with internal colleagues, identify and build relationships with KOLs and other experts to gain scientific and medical input on a variety of topics related to clinical development.\n\n - Draft and/or review clinical and scientific sections of regulatory submissions, including INDs and NDAs, and discussion documents for interactions with regulatory and Health Authorities.\n\n - Draft and review documents (including Investigator Brochures, clinical study protocols, and clinical study reports and regulatory submissions), as well as scientific publications (incl posters, abstracts, and manuscripts).\n\n - Participate in the review and interpretation of clinical trial data and provide insight into the clinical relevance of trial results.\n\n - Provide analyses of development strategies and options for discovery pipeline programs, including input into Proof-of-Concept trials, biomarker approaches, new research opportunities etc.\n\n - Support in-licensing and out-licensing activities and partner relationships as needed.\n\n - Present proposals and plans to variety of audiences, including to the Company’s Executive Leadership Team.\n\n - Contribute to the development of short- and long-term goals for the department in accordance with overall Company and Development strategies.\n\n - Participate in the planning and management of budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies.\n\n - Serve as clinical expert to provide clinical/scientific knowledge into the development, execution, and communication of a global clinical trial(s).\n\n - Actively collaborate with external clinical and other vendors on medical, scientific, psychometric data quality expectations, reviews and actions to ensure high quality and high integrity data generation.\n\n - Domestic and international travel may be required in the course of regular business activities.\n\n - Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies.\n\n - Recruit, lead, direct, develop, coach, and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n - Other duties as assigned.\n\nQUALIFICATIONS:\n\n - MD or MD/PhD with strong and versatile clinical development experience, ideally in psychiatry, preferably MDD. Experience in neurology disorders is an asset.\n\n - Minimum 8 years progressive development experience in the pharmaceutical or industry required (e.g., regulatory agency, academic research etc.) Majority of relevant experience is obtained in the industry setting.\n\n - Knowledge of pharmaceutical product development, product lifecycle, and commercialization processes.\n\n - Experience with developing study concepts for clinical development and clinical trial designs with cross functional input, including biostatistics, observational research and patient reported outcomes in Phase 3 clinical trials experience, including experience with clinical trials from concept to clinical study report is required.\n\n - Knowledge of Good Clinical Practices (GCP), FDA and EMEA/CHMP regulations and guidelines, and applicable international regulatory requirements.\n\n - Growth mindset, leadership experience and leadership potential as a clinical development expert and Medical Monitor in a complex matrix environment.\n\n - Ability to effectively present ideas and document complex medical/clinical concepts in both written and oral communication.\n\n - Strong interpersonal skills and problem-solving abilities while exhibiting superior judgment and a balanced, realistic understanding of issues and resolution path.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"520bcba6-50f3-488c-80c2-3bbfa82f4554","title":"Research Associate 1, Biology (In Vivo) (14 Month Contract)","department":"Discovery","team":"In Vivo Biology","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-08-24T17:46:26.108+00:00","isListed":true,"isRemote":false,"workplaceType":"OnSite","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/520bcba6-50f3-488c-80c2-3bbfa82f4554","applyUrl":"https://jobs.ashbyhq.com/xenon/520bcba6-50f3-488c-80c2-3bbfa82f4554/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Research Associate 1, Biology (In Vivo) to join our team on a 14-month contract. The incumbent will provide technical in vivo support for our preclinical drug discovery projects. The Research Associate 1, Biology (In Vivo) will participate in conducting in vivo pharmacology experiments to characterize the pharmacokinetics, efficacy and safety of compounds. The successful candidate has experience handling and ensuring the welfare of laboratory rodents, holds high ethical standards in animal care, and is responsible and detail-oriented. We are working in an accredited research facility holding Good Animal Practices (G.A.P.) certification from the Canadian Council on Animal Care (C.C.A.C).

This position reports to the Principal Scientist, Epilepsy and will be based out of Vancouver, BC, Canada. This role is an on-site, lab-based position. On-site positions require up to five on-site days per week.

RESPONSIBILITIES:

· Uphold high standards for animal care in accordance with CCAC guidelines.

· Work collaboratively with the In Vivo team to support efficacy and safety studies.

· Administer test compounds by all standard routes, as well as conduct pharmacokinetic experiments, and perform sample collection.

· Participate in and contribute to team meetings and other department activities; may present results or other key information as needed.

· Build productive internal working relationships to resolve mutual problems by collaborating on tasks and deliverables.

· Keep up to date and detailed records of experiments and data analysis within an Electronic Lab Notebook system. Ensure experiments are counter-signed.

· Ensure the laboratory environment is safe and well-organized; follow and keep up to date with Health & Safety policies.

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

· Other duties as assigned.

QUALIFICATIONS:

· BSc degree in a Life Science field or RVT Diploma, with a minimum of 6 months of experience working with laboratory rodents.

· Dedication to high standards of animal welfare.

· Experience conducting basic in vivo procedures, including evaluating health and welfare status, animal handling and care, drug administration using various routes and tissue collection is required.

· Detail-oriented work ethic with good organizational, time management and observational skills.

· Ability to work independently and collaboratively as part of a team.

· Excellent record keeping and communication skills.

· Ability to exercise mature judgment, discretion and initiative.

· Motivation to become proficient in operating new software programs.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Research Associate 1, Biology (In Vivo) to join our team on a 14-month contract. The incumbent will provide technical in vivo support for our preclinical drug discovery projects. The Research Associate 1, Biology (In Vivo) will participate in conducting in vivo pharmacology experiments to characterize the pharmacokinetics, efficacy and safety of compounds. The successful candidate has experience handling and ensuring the welfare of laboratory rodents, holds high ethical standards in animal care, and is responsible and detail-oriented. We are working in an accredited research facility holding Good Animal Practices (G.A.P.) certification from the Canadian Council on Animal Care (C.C.A.C).\n\nThis position reports to the Principal Scientist, Epilepsy and will be based out of Vancouver, BC, Canada. This role is an on-site, lab-based position. On-site positions require up to five on-site days per week.\n\nRESPONSIBILITIES:\n\n· Uphold high standards for animal care in accordance with CCAC guidelines.\n\n· Work collaboratively with the In Vivo team to support efficacy and safety studies.\n\n· Administer test compounds by all standard routes, as well as conduct pharmacokinetic experiments, and perform sample collection.\n\n· Participate in and contribute to team meetings and other department activities; may present results or other key information as needed.\n\n· Build productive internal working relationships to resolve mutual problems by collaborating on tasks and deliverables.\n\n· Keep up to date and detailed records of experiments and data analysis within an Electronic Lab Notebook system. Ensure experiments are counter-signed.\n\n· Ensure the laboratory environment is safe and well-organized; follow and keep up to date with Health & Safety policies.\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n· Other duties as assigned.\n\nQUALIFICATIONS:\n\n· BSc degree in a Life Science field or RVT Diploma, with a minimum of 6 months of experience working with laboratory rodents.\n\n· Dedication to high standards of animal welfare.\n\n· Experience conducting basic in vivo procedures, including evaluating health and welfare status, animal handling and care, drug administration using various routes and tissue collection is required.\n\n· Detail-oriented work ethic with good organizational, time management and observational skills.\n\n· Ability to work independently and collaboratively as part of a team.\n\n· Excellent record keeping and communication skills.\n\n· Ability to exercise mature judgment, discretion and initiative.\n\n· Motivation to become proficient in operating new software programs.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"206167dc-f5d8-409b-90ba-7db32cf41a56","title":"Associate Director/Director, Commercial Data Management","department":"Commercial","team":"Commercial Operations","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-07-21T18:06:01.117+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/206167dc-f5d8-409b-90ba-7db32cf41a56","applyUrl":"https://jobs.ashbyhq.com/xenon/206167dc-f5d8-409b-90ba-7db32cf41a56/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking an Associate Director / Director, Commercial Data Management, to help build and operate a trusted, governed, analytics-ready commercial data ecosystem in support of Xenon’s first anticipated product launch in epilepsy.

This role will serve as a key commercial business owner for commercial data management, master data management, data quality, data governance operations, reporting-ready data, and commercial data partner coordination. The role will ensure Xenon’s commercial data assets are accurate, timely, standardized, well-governed, and usable for launch performance measurement, field execution, targeting, segmentation, patient journey analytics, market access reporting, omnichannel measurement, and executive decision-making. The role will also ensure Xenon’s commercial data foundation is structured, governed, and sufficiently high quality to support future AI/ML-enabled capabilities, including predictive analytics, dynamic segmentation, next-best-action, automated insight generation, and launch performance optimization. Key partnerships for this role will span the entire Xenon commercial organization, including Analytics, Sales & Field Effectiveness, Market Access, and IT, as well as core vendor partnerships to manage the Commercial Data Ecosystem.

This position reports to the Senior Director, Data Strategy, Operations, Analytics & Reporting and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

Commercial Data Management & Operating Model

Master Data Management — HCP/HCO, Payer & Commercial Identity

Data Quality Management & Data Stewardship

Reporting-Ready Data, KPI Catalog & Business Definitions

Commercial Data Warehouse & Data Aggregation Platform Partnership

Ecosystem, Vendor & SLA Management

ADDITIONAL RESPONSIBILITIES:

QUALIFICATIONS:

Required

Preferred

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\n\n\nAbout the Role:\n\nWe are seeking an Associate Director / Director, Commercial Data Management, to help build and operate a trusted, governed, analytics-ready commercial data ecosystem in support of Xenon’s first anticipated product launch in epilepsy.\n\nThis role will serve as a key commercial business owner for commercial data management, master data management, data quality, data governance operations, reporting-ready data, and commercial data partner coordination. The role will ensure Xenon’s commercial data assets are accurate, timely, standardized, well-governed, and usable for launch performance measurement, field execution, targeting, segmentation, patient journey analytics, market access reporting, omnichannel measurement, and executive decision-making. The role will also ensure Xenon’s commercial data foundation is structured, governed, and sufficiently high quality to support future AI/ML-enabled capabilities, including predictive analytics, dynamic segmentation, next-best-action, automated insight generation, and launch performance optimization. Key partnerships for this role will span the entire Xenon commercial organization, including Analytics, Sales & Field Effectiveness, Market Access, and IT, as well as core vendor partnerships to manage the Commercial Data Ecosystem.\n\nThis position reports to the Senior Director, Data Strategy, Operations, Analytics & Reporting and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.\n\n\n\nRESPONSIBILITIES:\n\nCommercial Data Management & Operating Model\n\n - Collaborate with internal and external partners on developing and operationalizing Xenon’s commercial data ecosystem across pre-launch, launch, and post-launch phases\n\n - Manage and define how commercial data will be governed, documented, validated, accessed, escalated, and used across the organization\n\n - Serve as the primary commercial business partner managing Xenon’s core data service partners (e.g. CDW, Data Aggregator, MDM, etc.) and data source partners, (e.g. Claims, Rx, SP, Payer, etc.) IT Partnership\n\n - Partner closely with IT on commercial data platform implementation, platform enhancements, system dependencies, integration patterns, security, compliance, performance, lineage, and architecture alignment\n\n - Translate cross-functional commercial priorities into clear data management requirements, data ownership models, business rules, decision rights, and operating processes\n\nMaster Data Management — HCP/HCO, Payer & Commercial Identity\n\n - Serve as a commercial business owner or key steward for commercial master data management across HCP, HCO, affiliations, addresses, hierarchy, payer, payer bridge, customer master, and related identity domains\n\n - Establish and maintain data dictionaries, critical data elements, metadata, lineage, and business definitions for priority commercial master data domains\n\nData Quality Management & Data Stewardship\n\n - Design and manage a data stewardship process to ensure data quality issues are identified, communicated, prioritized, and resolved through consistent business-facing processes\n\n - Define, monitor, and evolve data quality rules, validation checks, reconciliation processes, completeness expectations, timeliness standards, accuracy thresholds, and issue escalation pathways\n\nReporting-Ready Data, KPI Catalog & Business Definitions\n\n - Support development of a governed KPI/metrics catalog into report-ready data assets with accompanying data dictionaries\n\n - Translate KPI and dashboard requirements into upstream data definitions, business rules, transformation logic, and validation expectations, for reporting and dashboard use\n\nCommercial Data Warehouse & Data Aggregation Platform Partnership\n\n - Partner with internal and vendor teams on go-live readiness (e.g. platform implementation, UAT, analytics/dashboards, etc.) and lifecycle management of data assets (e.g. Rx, Claims, CRM, payer, omnichannel engagement data, etc.)\n\n - Define commercial requirements for ingestion, data mapping, transformation, quality control, data dissemination, archival, lineage, and reporting readiness\n\nEcosystem, Vendor & SLA Management\n\n - Coordinate cross-vendor dependencies to ensure commercial data flows are complete, accurate, timely, and aligned to launch and steady state needs\n\n - Manage or support vendor deliverables including file layouts, data dictionaries, data transfer schedules, issue logs, quality checks, test files, SLA performance, and launch-readiness milestones\n \n \n\nADDITIONAL RESPONSIBILITIES:\n\n - Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans\n\n - Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies\n\n - Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n - Some international travel may be required\n\n - Other duties as assigned\n \n \n\nQUALIFICATIONS:\n\nRequired\n\n - Minimum undergraduate degree; 8+ years of relevant management experience or combination of degrees and experience\n\n - Advanced degree in business, analytics, data management, information systems, life sciences, public health, or related field preferred\n\n - 5+ years of experience in pharmaceutical, biotech, life sciences, healthcare data operations, data management, data governance, or related roles\n\n - Experience working with most commercial data sources such as Rx, claims, CRM, HCP/HCO, payer, field activity, digital engagement, specialty pharmacy, hub/patient services, distribution, sales/inventory, formulary, or access data\n\n - Experience supporting commercial data warehouse, data aggregation, MDM, data governance, data quality, reporting, or analytics initiatives\n\n - Experience managing data vendors, data aggregators, MDM vendors, commercial data platforms, or analytics implementation partners\n\n - Strong understanding of HCP/HCO and payer master data, affiliation management, data stewardship, business definitions, data dictionaries, metadata, lineage, and data quality management\n\n - Ability to translate business needs into data requirements, business rules, vendor specifications, validation criteria, and operational processes\n\n - Experience partnering with IT, analytics, vendors, Legal, Compliance, Privacy, and business stakeholders.\n\n - Strong project management, vendor management, communication, documentation, and cross-functional leadership skills\n\n - Ability to operate in a lean, fast-paced, pre-launch or launch-stage biotech environment\n\n\n\nPreferred\n\n - Experience supporting a first commercial launch or commercial data capability build in a small or mid-sized biotech\n\n - Experience with commercial data warehouse platforms, such as Snowflake, Azure, AWS, Boomi, Informatica, Veeva, Salesforce, IQVIA, Symphony, Komodo, MMIT, Definitive Healthcare, OneTrust, Power BI, Tableau, or related platforms/vendors\n\n - Experience with tokenization/de-identification, claims/Rx data, SP/hub data, patient journey analytics, omnichannel engagement data, or field execution data\n\n - Experience developing KPI catalogs, business glossaries, data dictionaries, quality rule catalogs, issue intake processes, or governed reporting-ready datasets\n\n - Experience supporting data foundations for advanced analytics (e.g. AI/ML, next-best-action, predictive modeling, dynamic targeting, automated reporting, commercial decision-support use cases, etc.)\n\n - Experience managing data stewardship process or team\n\n\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"007e541d-654b-4dd2-b719-1691f69060c0","title":"Discovery Operations Coordinator","department":"Discovery","team":"Discovery Program Management","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-08-13T18:14:02.254+00:00","isListed":true,"isRemote":false,"workplaceType":"OnSite","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/007e541d-654b-4dd2-b719-1691f69060c0","applyUrl":"https://jobs.ashbyhq.com/xenon/007e541d-654b-4dd2-b719-1691f69060c0/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a highly organized and detail-oriented Discovery Operations Coordinator to support our Discovery Program Management team with day-to-day administrative and research activities for the Vancouver office. The ideal candidate provides integrated operational support across Discovery, combining administrative operations, scientific data management, and laboratory inventory coordination. This role ensures the accuracy, accessibility, and efficiency of data, materials, and workflows that enable drug discovery activities and serves as a connector between lab teams, project teams, and digital systems. This role is ideal for someone who thrives in a fast-paced scientific environment and enjoys working across data, lab operations, and team coordination.

This position reports to the Manager, Discovery Operations and will be based out of Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. This is an on-site position, requiring up to 5 days in the office.

RESPONSIBILITIES:

· Provide administrative support to assigned Discovery senior leaders, including calendar management, travel coordination, and expense reimbursement. May provide onsite logistical support for meetings and events, including room setup and catering arrangements.

· Coordinate the receipt, organization, and upload of scientific data and reports from external contractors into Electronic Lab Notebook (ELN) and other enterprise systems, ensuring data quality, accuracy, traceability, and accessibility.

· Manage data workflows and facilitate the timely distribution of externally generated data, reports, and deliverables to appropriate stakeholders.

· Maintain and update information and finalized documents within enterprise digital platforms, ensuring accuracy, completeness, and compliance with established standards.

· Review, process, and archive Discovery reports and documentation to ensure consistency, completeness, and adherence to organizational requirements prior to finalization and distribution.

· In collaboration with scientific teams, maintain accurate records and inventory information across physical and digital systems as required.

· Collaborate with IT, scientific, and operational teams to support data ingestion, system workflows, and process improvements.

· Provide project coordination support, including scheduling meetings, coordinating logistics, and tracking routine project activities and deliverables.

· Maintain a safe, organized, and compliant laboratory and office environment by adhering to applicable Health & Safety policies and procedures.

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

· Other duties as assigned.

QUALIFICATIONS:

· A minimum of 2 years’ experience; Bachelor's Degree or professional diploma preferred.

· Excellent verbal, oral, and written communication skills. Ability to effectively communicate with cross-functional stakeholders for administrative or systems related issues.

· Highly organized with strong attention to detail.

· Flexible and able to manage multiple competing priorities.

· Ability to interface with internal and external stakeholders.

· Proficient computer skills (PowerPoint, Excel, Word, SharePoint).

· Willing and able to learn new skills to meet the changing needs of the organization.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a highly organized and detail-oriented Discovery Operations Coordinator to support our Discovery Program Management team with day-to-day administrative and research activities for the Vancouver office. The ideal candidate provides integrated operational support across Discovery, combining administrative operations, scientific data management, and laboratory inventory coordination. This role ensures the accuracy, accessibility, and efficiency of data, materials, and workflows that enable drug discovery activities and serves as a connector between lab teams, project teams, and digital systems. This role is ideal for someone who thrives in a fast-paced scientific environment and enjoys working across data, lab operations, and team coordination.\n\nThis position reports to the Manager, Discovery Operations and will be based out of Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. This is an on-site position, requiring up to 5 days in the office.\n\nRESPONSIBILITIES:\n\n· Provide administrative support to assigned Discovery senior leaders, including calendar management, travel coordination, and expense reimbursement. May provide onsite logistical support for meetings and events, including room setup and catering arrangements.\n\n· Coordinate the receipt, organization, and upload of scientific data and reports from external contractors into Electronic Lab Notebook (ELN) and other enterprise systems, ensuring data quality, accuracy, traceability, and accessibility.\n\n· Manage data workflows and facilitate the timely distribution of externally generated data, reports, and deliverables to appropriate stakeholders.\n\n· Maintain and update information and finalized documents within enterprise digital platforms, ensuring accuracy, completeness, and compliance with established standards.\n\n· Review, process, and archive Discovery reports and documentation to ensure consistency, completeness, and adherence to organizational requirements prior to finalization and distribution.\n\n· In collaboration with scientific teams, maintain accurate records and inventory information across physical and digital systems as required.\n\n· Collaborate with IT, scientific, and operational teams to support data ingestion, system workflows, and process improvements.\n\n· Provide project coordination support, including scheduling meetings, coordinating logistics, and tracking routine project activities and deliverables.\n\n· Maintain a safe, organized, and compliant laboratory and office environment by adhering to applicable Health & Safety policies and procedures.\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n· Other duties as assigned.\n\nQUALIFICATIONS:\n\n· A minimum of 2 years’ experience; Bachelor's Degree or professional diploma preferred.\n\n· Excellent verbal, oral, and written communication skills. Ability to effectively communicate with cross-functional stakeholders for administrative or systems related issues.\n\n· Highly organized with strong attention to detail.\n\n· Flexible and able to manage multiple competing priorities.\n\n· Ability to interface with internal and external stakeholders.\n\n· Proficient computer skills (PowerPoint, Excel, Word, SharePoint).\n\n· Willing and able to learn new skills to meet the changing needs of the organization.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"3332e595-4aff-487f-80ee-0d5bfa9e86b7","title":"Senior Director, Quality Assurance, Commercial","department":"R&D Operations","team":"QA","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-07-28T16:47:20.808+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/3332e595-4aff-487f-80ee-0d5bfa9e86b7","applyUrl":"https://jobs.ashbyhq.com/xenon/3332e595-4aff-487f-80ee-0d5bfa9e86b7/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Senior Director, Quality Assurance, Commercial as an integral leader within the Quality GMP team as well as a key member of highly collaborative R&D Operations group comprised of Program Management, CMC, Regulatory Affairs, Supply Chain and Quality functions. Leveraging an extensive background in Quality and all manufacturing stages (Drug Substance, Drug Product, Finished Goods) of products for commercial distribution will ensure the Quality program requirements are met. The successful candidate will have proven leadership ability in a fast-paced and complex environment, and will interact with all levels of internal staff, as well as with external advisors and partners.

This position reports to the Executive Director, Quality Assurance, GMP and will be based out of Boston, MA, USA in our Needham office. We may consider other jurisdictions for exceptional candidates. This role is a hybrid position, requiring a minimum of 2 days per week in the office.

RESPONSIBILITIES:

· Lead and manage key activities related to commercial manufacturing, testing and disposition of product at CMOs in accordance with regulatory and internal requirements. This includes, but not limited to, batch reviews and release, tech transfers and validations, deviations, quality agreements, and supplier qualifications including auditing and monitoring.

· Effectively lead and manage a global team to ensure functional and program objectives are met

· Collaborate and partner with leaders within the CMC and Supply Chain organization to ensure key objectives for commercial programs and small molecule products; ensure cGMP compliance and realization of value-added policies and best practices.

· Recommend and implement strategic system improvements for commercial Quality requirements such as CPV, APR, KPI metrics, as required.

· Attend CMO and internal CMC team meetings; provide feedback and collaborate on complex investigations. Escalate or advise key topics, as required.

· Support the Quality Systems team and contribute to product review meetings; present Quality metrics (internal and vendor metrics). Provide timely reports and reviews of key CMC and health authority documents.

· Represent the Quality function as a trusted advisor on product development teams (PDTs), Health Authority Inspections, for suppliers and at CMO operational meetings, including “QA to QA” meetings.

· Promote a Quality and patient-first mindset and inspire Quality excellence throughout to the organization.

· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

· Some international travel may be required.

· Other duties as assigned.

QUALIFICATIONS:

· Bachelor’s degree in a life sciences discipline, with 12+ years of relevant management experience in GMP quality leadership positions; an advanced degree is preferred.

· Strong understanding of small molecule manufacturing including drug substance manufacture, drug product manufacture with direct experience in solid oral dosage and finished goods production and distribution. Must have experience with virtual manufacturing partners.

· Extensive GxP knowledge with commercial production/disposition experience.

· Strong knowledge of global GxP expectations and QP (Qualified Person) requirements.

· Ability to effectively organize, multitask, and work in a fast-paced, deadline driven work environment.

· Extensive experience establishing key quality system metrics and process indicators to proactively identify and address quality systems or product issues.

· Strong interpersonal skills, with experience in leading cross functional projects including a successful track record working with suppliers and CMOs.

· Ability to communicate in a proactive and solution-focused manner, including keeping management aware of potential issues. Ability to communicate issues with CMOs.

· Goal oriented with the ability to troubleshoot and resolve problems.

· Be a champion for continuous improvement in all aspects of total quality management.

· Ability to work independently to set priorities to meet timelines

· Previous experience leading and managing on-site and remote employees.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Senior Director, Quality Assurance, Commercial as an integral leader within the Quality GMP team as well as a key member of highly collaborative R&D Operations group comprised of Program Management, CMC, Regulatory Affairs, Supply Chain and Quality functions. Leveraging an extensive background in Quality and all manufacturing stages (Drug Substance, Drug Product, Finished Goods) of products for commercial distribution will ensure the Quality program requirements are met. The successful candidate will have proven leadership ability in a fast-paced and complex environment, and will interact with all levels of internal staff, as well as with external advisors and partners.\n\nThis position reports to the Executive Director, Quality Assurance, GMP and will be based out of Boston, MA, USA in our Needham office. We may consider other jurisdictions for exceptional candidates. This role is a hybrid position, requiring a minimum of 2 days per week in the office.\n\nRESPONSIBILITIES:\n\n· Lead and manage key activities related to commercial manufacturing, testing and disposition of product at CMOs in accordance with regulatory and internal requirements. This includes, but not limited to, batch reviews and release, tech transfers and validations, deviations, quality agreements, and supplier qualifications including auditing and monitoring.\n\n· Effectively lead and manage a global team to ensure functional and program objectives are met\n\n· Collaborate and partner with leaders within the CMC and Supply Chain organization to ensure key objectives for commercial programs and small molecule products; ensure cGMP compliance and realization of value-added policies and best practices.\n\n· Recommend and implement strategic system improvements for commercial Quality requirements such as CPV, APR, KPI metrics, as required.\n\n· Attend CMO and internal CMC team meetings; provide feedback and collaborate on complex investigations. Escalate or advise key topics, as required.\n\n· Support the Quality Systems team and contribute to product review meetings; present Quality metrics (internal and vendor metrics). Provide timely reports and reviews of key CMC and health authority documents.\n\n· Represent the Quality function as a trusted advisor on product development teams (PDTs), Health Authority Inspections, for suppliers and at CMO operational meetings, including “QA to QA” meetings.\n\n· Promote a Quality and patient-first mindset and inspire Quality excellence throughout to the organization.\n\n· Recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n· Some international travel may be required.\n\n· Other duties as assigned.\n\nQUALIFICATIONS:\n\n· Bachelor’s degree in a life sciences discipline, with 12+ years of relevant management experience in GMP quality leadership positions; an advanced degree is preferred.\n\n· Strong understanding of small molecule manufacturing including drug substance manufacture, drug product manufacture with direct experience in solid oral dosage and finished goods production and distribution. Must have experience with virtual manufacturing partners.\n\n· Extensive GxP knowledge with commercial production/disposition experience.\n\n· Strong knowledge of global GxP expectations and QP (Qualified Person) requirements.\n\n· Ability to effectively organize, multitask, and work in a fast-paced, deadline driven work environment.\n\n· Extensive experience establishing key quality system metrics and process indicators to proactively identify and address quality systems or product issues.\n\n· Strong interpersonal skills, with experience in leading cross functional projects including a successful track record working with suppliers and CMOs.\n\n· Ability to communicate in a proactive and solution-focused manner, including keeping management aware of potential issues. Ability to communicate issues with CMOs.\n\n· Goal oriented with the ability to troubleshoot and resolve problems.\n\n· Be a champion for continuous improvement in all aspects of total quality management.\n\n· Ability to work independently to set priorities to meet timelines\n\n· Previous experience leading and managing on-site and remote employees.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"40bf93e6-fdac-465a-9c48-4be1c6477283","title":"Senior Manager/Associate Director, Quality & Supply Chain Systems","department":"General & Administration","team":"Information Technology","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-06T16:09:40.790+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/40bf93e6-fdac-465a-9c48-4be1c6477283","applyUrl":"https://jobs.ashbyhq.com/xenon/40bf93e6-fdac-465a-9c48-4be1c6477283/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Senior Manager/Associate Director, Quality & Supply Chain Systems to join our team. The Senior Manager/Associate Director, Quality & Supply Chain Systems will support the implementation and management of the Quality and Supply Chain IT systems. This individual will partner with leaders across Quality and Supply Chain, and other functions as needed to drive adoption, operations, and ongoing enhancements to the IT systems.

This position reports to the Director, Development Information Systems and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\n\n\nAbout the Role:\n\nWe are seeking a Senior Manager/Associate Director, Quality & Supply Chain Systems to join our team. The Senior Manager/Associate Director, Quality & Supply Chain Systems will support the implementation and management of the Quality and Supply Chain IT systems. This individual will partner with leaders across Quality and Supply Chain, and other functions as needed to drive adoption, operations, and ongoing enhancements to the IT systems.\n\nThis position reports to the Director, Development Information Systems and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.\n\n\n\nRESPONSIBILITIES:\n\n - Partner with functional stakeholders and vendors to build new solutions supporting the Quality and Supply Chain functions, including integrations between systems and between Xenon and key service providers.\n\n - Author, review, and approve applicable SDLC deliverables, and coordinate assurance and other testing activities.\n\n - Develop, review, and approve procedures defining System Administration activities.\n\n - Collaborate with Xenon’s Architecture Review Board to ensure the system design is consistent with company standards for security, infrastructure, and data architecture.\n\n - Own the day-to-day operations and configurations of Supply Chain Systems (iStability, Oracle Fusion ERP, etc.).\n\n - Support the day-to-day operations and configuration of the Veeva Development suite (RIM, Quality, etc.).\n\n - Support the day-to-day operations and configuration of other Development IT systems (SAS, Egnyte, etc.).\n\n - Maintain hands on involvement in system administration and configuration, including workflows, metadata, security, reference data, and system settings.\n\n - Perform user administration and manage licensing across Quality and Supply Chain IT systems.\n\n - Support the design, development, and documentation of effective data flows and integrations among systems to enable efficient processes and workflows (including automation) and effective reporting and analytics.\n\n - Support user onboarding, system training, and operational adoption from a system and process perspective.\n\n - Collaborate with key stakeholders to develop and maintain roadmaps, continuous improvement initiatives, and system standardization efforts.\n\n - Manage vendor/MSP relationships related to IT systems.\n\n - Provide technical guidance and support on change control activities.\n\n - Ensure ongoing compliance with Xenon procedures including SaaS Release Management, Change Management, Problem Management, etc.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n - Other duties as assigned.\n \n \n\nQUALIFICATIONS:\n\n - Bachelor’s degree in Information Systems, Computer Science, Business Administration or related field.\n\n - Minimum of 5 years of relevant experience, preferably in the Life Sciences industry. Experience supporting pre commercial or early commercial biotech organizations preferred.\n\n - Proven experience with the Veeva suite of products, Supply Chain planning and execution systems (including ERP), and other key Development IT systems (Veeva certification a plus).\n\n - Strong understanding of the Quality and Supply Chain business processes.\n\n - Knowledge of user management administration.\n\n - Experience managing vendors/MSPs and collaborating with business stakeholders to prioritize support or enhancement requests.\n\n - Experience with system integrations (APIs, data flows, connectors).\n\n - Excellent communication and coordination skills across business and technical teams.\n\n - Ability to manage multiple priorities in a fast-paced environment.\n\n - Strong problem-solving skills and attention to detail.\n \n \n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"83117f28-4a66-40a3-9205-08e1e3c6d9a1","title":"Animal Care Technician","department":"Discovery","team":"Resource Facility","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-08-04T19:27:10.227+00:00","isListed":true,"isRemote":false,"workplaceType":"OnSite","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/83117f28-4a66-40a3-9205-08e1e3c6d9a1","applyUrl":"https://jobs.ashbyhq.com/xenon/83117f28-4a66-40a3-9205-08e1e3c6d9a1/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking an Animal Care Technician for the Resource Facility, to join our animal care team. This position will provide husbandry and facility maintenance to support preclinical research in drug discovery. The successful candidate has experience handling and ensuring the welfare of animals, holds high ethical standards in animal care, and is responsible and detail-oriented. You will be working in an accredited research facility holding Good Animal Practices (G.A.P.) certification from the Canadian Council on Animal Care (C.C.A.C).

This position reports to the Manager, Resource Facility and will be in the Vancouver, BC, Canada location. The level of the position will be commensurate with the candidate’s education and industry experience. This role is an on-site, lab-based position requiring up to five on-site days per week.

RESPONSIBILITIES:

· Perform routine husbandry duties associated with animal care for mice and rats.

· Ensure cleanliness of the entire facility, including but not limited to, cleaning and disinfecting floors, surfaces, cage systems, and equipment maintenance.

· Monitor and ensure overall health and welfare of animals in accordance with CCAC guidelines.

· Conduct daily health checks of all animals and keep detailed documents and records.

· Receive incoming animals ordered from vendors.

· Maintain animal health records within environmental facility parameters.

· Ensure data is entered into software systems and organize health records in an accurate and timely fashion.

· Remove biohazardous waste, sharps, and other biological waste as per established procedures.

· Monitor and maintain inventory supply (feed, bedding, etc.); seek to ensure procedure rooms are always stocked and functional.

· Collect tissue samples for genotyping.

· Assist and participate in technical procedures and studies in collaboration with in vivo Research Associates.

· Assist with formulation preparation.

· Use professional concepts and SOPs to solve a variety of problems.

· Routinely performs weighing animals, anesthesia administration and euthanasia.

· Work within established guidelines, policies, SOPs and safety requirements.

· Prioritize urgent and important responsibilities, such as animal care, facility maintenance, and meetings pertaining to studies that are being conducted.

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

· Other duties as assigned.

QUALIFICATIONS:

· Post-secondary education in a life sciences discipline is desired. Strong desire to learn and apply technical skills.

· Previous experience working with and caring for animals is an asset.

· Detail-oriented with good organizational, time management and observational skills.

· Ability to work independently and collaboratively as part of a team. Participate in cross-functional activities, as needed.

· Good interpersonal and clear communication skills.

· Ability to exercise mature judgment, discretion, and initiative.

· Capable of lifting to 25kg.

· Ability to work rotational weekends and statutory holidays.

· Basic computer skills include spreadsheets and word processing.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking an Animal Care Technician for the Resource Facility, to join our animal care team. This position will provide husbandry and facility maintenance to support preclinical research in drug discovery. The successful candidate has experience handling and ensuring the welfare of animals, holds high ethical standards in animal care, and is responsible and detail-oriented. You will be working in an accredited research facility holding Good Animal Practices (G.A.P.) certification from the Canadian Council on Animal Care (C.C.A.C).\n\nThis position reports to the Manager, Resource Facility and will be in the Vancouver, BC, Canada location. The level of the position will be commensurate with the candidate’s education and industry experience. This role is an on-site, lab-based position requiring up to five on-site days per week.\n\nRESPONSIBILITIES:\n\n· Perform routine husbandry duties associated with animal care for mice and rats.\n\n· Ensure cleanliness of the entire facility, including but not limited to, cleaning and disinfecting floors, surfaces, cage systems, and equipment maintenance.\n\n· Monitor and ensure overall health and welfare of animals in accordance with CCAC guidelines.\n\n· Conduct daily health checks of all animals and keep detailed documents and records.\n\n· Receive incoming animals ordered from vendors.\n\n· Maintain animal health records within environmental facility parameters.\n\n· Ensure data is entered into software systems and organize health records in an accurate and timely fashion.\n\n· Remove biohazardous waste, sharps, and other biological waste as per established procedures.\n\n· Monitor and maintain inventory supply (feed, bedding, etc.); seek to ensure procedure rooms are always stocked and functional.\n\n· Collect tissue samples for genotyping.\n\n· Assist and participate in technical procedures and studies in collaboration with in vivo Research Associates.\n\n· Assist with formulation preparation.\n\n· Use professional concepts and SOPs to solve a variety of problems.\n\n· Routinely performs weighing animals, anesthesia administration and euthanasia.\n\n· Work within established guidelines, policies, SOPs and safety requirements.\n\n· Prioritize urgent and important responsibilities, such as animal care, facility maintenance, and meetings pertaining to studies that are being conducted.\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n· Other duties as assigned.\n\nQUALIFICATIONS:\n\n· Post-secondary education in a life sciences discipline is desired. Strong desire to learn and apply technical skills.\n\n· Previous experience working with and caring for animals is an asset.\n\n· Detail-oriented with good organizational, time management and observational skills.\n\n· Ability to work independently and collaboratively as part of a team. Participate in cross-functional activities, as needed.\n\n· Good interpersonal and clear communication skills.\n\n· Ability to exercise mature judgment, discretion, and initiative.\n\n· Capable of lifting to 25kg.\n\n· Ability to work rotational weekends and statutory holidays.\n\n· Basic computer skills include spreadsheets and word processing.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"33a25ecf-b412-4b9b-bb40-87957ac03f2e","title":"Director, Medical Information","department":"Clinical Development","team":"Medical Affairs","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-13T16:30:22.375+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/33a25ecf-b412-4b9b-bb40-87957ac03f2e","applyUrl":"https://jobs.ashbyhq.com/xenon/33a25ecf-b412-4b9b-bb40-87957ac03f2e/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role

We are seeking a Director, Medical Information to support the establishment, scaling, and evolution of the Medical Information (MI) function at Xenon. This role drives functional priorities for, and execution of medical inquiry management, scientific response content development, contact center operations, and digital medical information capabilities to support Medical Affairs, Clinical Development, and Commercial launch readiness. To be successful in this role, you must be a strong operational leader with a service-oriented and collaborative mindset. You are someone driven by scientific rigor, operational excellence, and cross-functional alignment to manage a scalable, future-ready MI ecosystem that integrates data, content, and digital innovation to support healthcare professionals, patients, and internal stakeholders.

This position reports to the Executive Director, Medical Information and partners closely with Pharmacovigilance & Drug Safety, Quality, Regulatory, Commercial, Market Access, Clinical Development, Legal/Compliance, and Medical Affairs. The position plays a critical role in launch readiness and operational execution, ensuring Xenon delivers high-quality, compliant, and timely medical information for our products and pipeline.

This position will be based out of Boston, MA, USA in our Needham office. This role is a hybrid position, requiring a minimum of 2 days per week in the office. We will consider other jurisdictions for exceptional candidates.

RESPONSIBILITIES:

Strategic Leadership & MI Architecture

Medical Information Operations & Contact Center Leadership

Scientific Content & Response Excellence

Inquiry Management & Compliance Oversight

Systems, Data & Analytics Leadership, and Cross-Functional Collaboration

People Leadership & Team Development

Other Responsibilities

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role\n\nWe are seeking a Director, Medical Information to support the establishment, scaling, and evolution of the Medical Information (MI) function at Xenon. This role drives functional priorities for, and execution of medical inquiry management, scientific response content development, contact center operations, and digital medical information capabilities to support Medical Affairs, Clinical Development, and Commercial launch readiness. To be successful in this role, you must be a strong operational leader with a service-oriented and collaborative mindset. You are someone driven by scientific rigor, operational excellence, and cross-functional alignment to manage a scalable, future-ready MI ecosystem that integrates data, content, and digital innovation to support healthcare professionals, patients, and internal stakeholders.\n\nThis position reports to the Executive Director, Medical Information and partners closely with Pharmacovigilance & Drug Safety, Quality, Regulatory, Commercial, Market Access, Clinical Development, Legal/Compliance, and Medical Affairs. The position plays a critical role in launch readiness and operational execution, ensuring Xenon delivers high-quality, compliant, and timely medical information for our products and pipeline.\n\nThis position will be based out of Boston, MA, USA in our Needham office. This role is a hybrid position, requiring a minimum of 2 days per week in the office. We will consider other jurisdictions for exceptional candidates.\n\nRESPONSIBILITIES:\n\nStrategic Leadership & MI Architecture\n\n - Operationalize the end-to-end vision, strategy, and execution of the Medical Information function, including contact center operations, digital capabilities, and scientific content management, including readiness for commercialization and oversight of internal/external resources.\n\n - Build and deploy scalable operating models for MI, including SOPs, workflows, and governance in partnership with Legal, Compliance, PV/DS, Quality, Clin Dev, and Med Affairs.\n\n - Work with manager and Medical Affairs stakeholders to refine and execute process for the authoring and lifecycle management of Standard Response Letters (SRLs) and scientific content, ensuring accuracy, consistency, and alignment with clinical data, publications, and regulatory requirements.\n\n - Support MI alignment with enterprise efforts in omnichannel MI delivery and self-service portals.\n\nMedical Information Operations & Contact Center Leadership\n\n - Execute and manage MI contact center capability build including vendor selection, onboarding, training, and performance management.\n\n - Operational oversight and performance management of MI vendors (e.g., contact center, content support), including training, QA, and continuous improvement.\n\n - Work with internal company stakeholders to develop and manage a Medical Information portal to enable compliant, self-service access to approved content\n\n - Monitor and report on tactical plan execution to ensure accurate forecasting of budget / spend, resource utilization, and anticipated executional risks.\n\nScientific Content & Response Excellence\n\n - Partner with Medical Affairs, Clinical Development, and Scientific Communications to ensure alignment of scientific messaging within the MI function.\n\n - Leverage internal and external resources to support content authoring, review and approval and ensure high-quality, consistent scientific responses\n\n - Ensure content accuracy, consistency, and appropriate risk framing aligned with clinical data, publications, and regulatory milestones and maintain a high-quality content library.\n\n - Responsible for advancing MI materials through the MLR review processes, ensuring timely approvals and compliance\n\n - Deliver timely, accurate, high-quality, empathetic, and patient-centered communications\n\nInquiry Management & Compliance Oversight\n\n - Day-to-day management of contact center vendor to ensure efficient inquiry intake, triage/escalation, fulfillment, and documentation processes aligned with regulatory standards, maintaining audit and inspection readiness of MI processes and systems\n\n - Partner with PV/DS and Quality to ensure appropriate AE/PC identification, reporting and reconciliation\n\n - Drive adherence to internal policies to ensure compliant handling of medical inquiries, including complex, escalated requests\n\nSystems, Data & Analytics Leadership, and Cross-Functional Collaboration\n\n - Partner with IT, Medical Ops and Commercial Ops to maintain scalable MI infrastructure\n\n - Partner with IT, Medical Ops, and Commercial Ops to ensure MI data flows into appropriate enterprise systems and supports reporting needs\n\n - Act as the primary operational liaison for MI contact center vendor, Med Affairs functional teams and IT project teams\n\n - Execute and monitor MI KPIs and dashboards, supporting the translation of data into actionable insights\n\nPeople Leadership & Team Development\n\n - Lead and manage a high-performing, outsourced Medical Information contact center team.\n\n - Provide training/feedback and oversight of contact center vendor managers and agents while fostering a culture of accountability, collaboration, and continuous improvement.\n\nOther Responsibilities\n\n - Conduct all activities in accordance with company policies, timelines, and quality standards.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n - Perform additional duties as assigned to support Medical Affairs objectives and evolving business needs.\n\nQUALIFICATIONS:\n\n - PhD, PharmD, MD, or equivalent advanced scientific degree\n\n - 7+ years of management experience in Medical Affairs with significant (5+ years) Medical Information experience.\n\n - Demonstrated experience executing and optimizing Medical Information functions in pre-commercial or commercial environments\n\n - Expertise in scientific response content authoring, inquiry management, and MLR review processes\n\n - Experience engaging with/managing MI contact centers and external vendors\n\n - Strong knowledge of regulatory and compliance requirements for MI reporting (FDA, EMA)\n\n - History of leadership, strategic thinking, and operational execution skills in previous roles\n\n - Excellent communication and cross-functional collaboration skills\n\n - Experience working cross‑functionally within Med Affairs, PV/DS, Clin Dev, or related functions\n\n - Neuroscience experience preferred; epilepsy experience a plus\n\n - Strong scientific acumen, critical thinking skills, and attention to detail\n\n - Ability to manage multiple projects and collaborate effectively in a fast-paced, matrix environment\n\n - Willingness to travel up to 15-20% domestically and internationally as needed\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"02e7aac3-cf99-4154-b9af-470dfb31bcef","title":"Senior Project Manager/Associate Director, Discovery Project Management","department":"Discovery","team":"Discovery Program Management","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-08-11T18:18:38.944+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/02e7aac3-cf99-4154-b9af-470dfb31bcef","applyUrl":"https://jobs.ashbyhq.com/xenon/02e7aac3-cf99-4154-b9af-470dfb31bcef/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Senior Project Manager/Associate Director, Discovery Project Management to join our team. This individual will work flexibly across a number of Discovery-stage small molecule programs. This role involves close coordination with stakeholders within Discovery (e.g., Chemistry, Biology, Compound Properties, Toxicology and CMC) and outside of Discovery (e.g., Finance, Legal, QA, Development).

This position reports to the Director, Discovery Project Management and will be based out of Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

· Develop and maintain comprehensive project/program/portfolio management and tracking tools addressing program scope, components, schedule and budget.

· Manage the Company’s Discovery-stage Contract Research Organizations (CROs) under both full-time equivalent and fee-for-service arrangements.

· Perform contract-related activities (drafting, contract change control, monitoring for performance, accepting deliverables, managing invoices and tracking accruals) relating to same within the scope of the Company’s contact management systems and policies.

· Coordinate Discovery-stage external studies including compound logistics, protocol drafting and review and communication with study directors.

· Coordinate project team, project sub-team, and functional group meetings for the Company’s Discovery stage programs. Track action items and timelines. Understand and communicate critical path towards key objectives. Schedule internal and external studies, as required.

· Facilitate cross-functional alignment with key Discovery stakeholders, identify potential cross-functional issues and bottlenecks across a multi-year horizon.

· Develop, optimize and manage data workflows and progression of compounds through program flowcharts. Ensure the timely distribution of externally-generated data and reports to appropriate stakeholders.

· Support activities that raise the scientific profile of the Company internally and externally, including Discovery training, Discovery invited speaker and Discovery events.

· Support Discovery scientific disclosure approvals under the Scientific Methods Based Disclosure Approval Process.

· Manage drafting, review and approval of Discovery preclinical reports to support regulatory filings.

· Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans.

· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any

· Other duties as assigned

QUALIFICATIONS:

· MSc or PhD in the fields of chemistry or biology

· At least 5 years' experience in drug discovery in the biotech or pharmaceutical industry

· Project management experience is preferred

· Excellent communication skills, both oral and written

· Highly organized with keen attention to detail

· Strong desire to manage projects to timeline and budget

· Ability to interface with internal and external stakeholders including scientists, executives, and members of the finance and legal departments; ability to influence colleagues in a cross-functional team environment

· Extensive intermediate to advanced computer skills (Power Point, Excel, Word, MS Project, SharePoint)

· Knowledge of project management methodology and technology, including developing Gantt Charts

· Willing and able to learn new skills to meet changing needs of the organization. Flexible and able to efficiently prioritize tasks

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Senior Project Manager/Associate Director, Discovery Project Management to join our team. This individual will work flexibly across a number of Discovery-stage small molecule programs. This role involves close coordination with stakeholders within Discovery (e.g., Chemistry, Biology, Compound Properties, Toxicology and CMC) and outside of Discovery (e.g., Finance, Legal, QA, Development).\n\nThis position reports to the Director, Discovery Project Management and will be based out of Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\n· Develop and maintain comprehensive project/program/portfolio management and tracking tools addressing program scope, components, schedule and budget.\n\n· Manage the Company’s Discovery-stage Contract Research Organizations (CROs) under both full-time equivalent and fee-for-service arrangements.\n\n· Perform contract-related activities (drafting, contract change control, monitoring for performance, accepting deliverables, managing invoices and tracking accruals) relating to same within the scope of the Company’s contact management systems and policies.\n\n· Coordinate Discovery-stage external studies including compound logistics, protocol drafting and review and communication with study directors.\n\n· Coordinate project team, project sub-team, and functional group meetings for the Company’s Discovery stage programs. Track action items and timelines. Understand and communicate critical path towards key objectives. Schedule internal and external studies, as required.\n\n· Facilitate cross-functional alignment with key Discovery stakeholders, identify potential cross-functional issues and bottlenecks across a multi-year horizon.\n\n· Develop, optimize and manage data workflows and progression of compounds through program flowcharts. Ensure the timely distribution of externally-generated data and reports to appropriate stakeholders.\n\n· Support activities that raise the scientific profile of the Company internally and externally, including Discovery training, Discovery invited speaker and Discovery events.\n\n· Support Discovery scientific disclosure approvals under the Scientific Methods Based Disclosure Approval Process.\n\n· Manage drafting, review and approval of Discovery preclinical reports to support regulatory filings.\n\n· Develop and propose short- and long-term objectives for the function in accordance with overall Company strategies and plans.\n\n· Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any\n\n· Other duties as assigned\n\nQUALIFICATIONS:\n\n· MSc or PhD in the fields of chemistry or biology\n\n· At least 5 years' experience in drug discovery in the biotech or pharmaceutical industry\n\n· Project management experience is preferred\n\n· Excellent communication skills, both oral and written\n\n· Highly organized with keen attention to detail\n\n· Strong desire to manage projects to timeline and budget\n\n· Ability to interface with internal and external stakeholders including scientists, executives, and members of the finance and legal departments; ability to influence colleagues in a cross-functional team environment\n\n· Extensive intermediate to advanced computer skills (Power Point, Excel, Word, MS Project, SharePoint)\n\n· Knowledge of project management methodology and technology, including developing Gantt Charts\n\n· Willing and able to learn new skills to meet changing needs of the organization. Flexible and able to efficiently prioritize tasks\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"c64918b6-dca6-44b8-8851-ab6943a7432d","title":"Senior Manager/Associate Director, Quality Control","department":"R&D Operations","team":"CMC Quality Control","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-08-11T15:06:19.189+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/c64918b6-dca6-44b8-8851-ab6943a7432d","applyUrl":"https://jobs.ashbyhq.com/xenon/c64918b6-dca6-44b8-8851-ab6943a7432d/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking an experienced Senior Manager/Associate Director, Quality Control to lead Quality Control activities supporting clinical and commercial drug substance (DS) and drug product (DP) programs in accordance with ICH and cGMP requirements. The ideal candidate will have a strong background in small molecules, with experience spanning early to late clinical phases through registration, PPQ, and commercial stages. This role requires expertise in managing analytical testing, specifications, stability program, reference standards, investigations, and quality control oversight across DS and DP manufacturing and testing campaigns. The ideal candidate will be collaborative, science and data driven, and thrive working in a fast-paced environment.

This position reports to the Director, Quality Control and will be based out of Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking an experienced Senior Manager/Associate Director, Quality Control to lead Quality Control activities supporting clinical and commercial drug substance (DS) and drug product (DP) programs in accordance with ICH and cGMP requirements. The ideal candidate will have a strong background in small molecules, with experience spanning early to late clinical phases through registration, PPQ, and commercial stages. This role requires expertise in managing analytical testing, specifications, stability program, reference standards, investigations, and quality control oversight across DS and DP manufacturing and testing campaigns. The ideal candidate will be collaborative, science and data driven, and thrive working in a fast-paced environment.\n\nThis position reports to the Director, Quality Control and will be based out of Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.\n\nRESPONSIBILITIES:\n\n - Review, manage all analytical/non-analytical results for product release, and stability, including OOS and OOT observations. Organize and file internal and external quality control data, protocols, and reports.\n\n - Lead the assigned program’s stability activities, including trending, statistical evaluation, and scientific interpretation of stability data to assess product performance throughout its lifecycle, support shelf-life extensions and expiry dating justifications, and proactively identify and evaluate emerging stability risks and trends.\n\n - Manage the reference standard program for the assigned clinical/commercial program at dedicated external labs, including qualification and distribution of reference standards to all manufacturing & testing facilities.\n\n - Manage master specifications for starting materials, reference standards, API, and drug products for assigned clinical/commercial program(s).\n\n - Manage stability studies for reference standards, API, and drug products for assigned programs. Compile stability protocols and monitor all stability data, including shelf-life trending and extensions.\n\n - Lead investigations and draft reports for out-of-specification (OOS) and out-of-trend (OOT) results during release and stability testing in close collaboration with internal teams and external testing labs.\n\n - Manage the review and approval workflow for feasibility/comparability studies, validation protocols, reports, and test methods with internal experts and external partners.\n\n - Lead quality control checks on the CMC sections of regulatory submissions (e.g., Investigational New Drugs (INDs), Clinical Trial Applications (CTAs), and New Drug Applications (NDAs).\n\n - In collaboration with QA, manage internal release documents for drug substances, drug products, and reference standards, including Certificate of Analysis and Certificate of Testing in collaboration with quality assurance.\n\n - Effectively collaborate with colleagues in Drug Product and API groups, such that deliverables are optimal for use in clinical trial material.\n\n - Ensure effective working relationships with external laboratories and CMOs, participate in remote audits, and perform on-site audits as required.\n\n - Provide technical knowledge of quality control to support the transfer of new drug candidates from research/discovery groups to the CMC drug development team.\n\n - Oversee the movement of samples between external testing partners and CMOs for tech transfers, release, and stability testing of assigned program(s).\n\n - Engage in and ensure compliance with appropriate quality functions, including deviations, change controls, and CAPAs.\n\n - May recruit, lead, direct, develop, coach and evaluate direct reports, if any, in accordance with the Company’s Human Resource policies and practices.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n - Some international travel may be required.\n\n - Other duties as assigned.\n\nQUALIFICATIONS:\n\n - An undergraduate degree in life sciences, with 5+ years (Senior Manager level) or 8+ years (Associate Director level) of relevant management experience in the pharmaceutical industry (small molecules and/or biologics).\n\n - Previous experience working with external testing laboratories; independently and influences in a fast-paced environment, while exhibiting a strong quality mindset.\n\n - Comfortable working across locations and time zones.\n\n - Experience auditing external laboratories, FDA/EMA inspections, and inspection readiness is preferred.\n\n - Strong experience with quality control testing, stability program management in accordance with ICH guidelines, master specifications, method validations, investigations (OOS/OOT), batch release processes, and quality management systems are required.\n\n - Prior experience with IND, NDA and/or CTA CMC submissions is preferred; knowledge of cGMP and the US, Canadian, and EU regulatory environments.\n\n - Collaboration and inclusion between external testing labs and cross-functional CMC teams are essential.\n\n - Excellent oral and written communication skills and previous team leadership experience.\n\n - Willingness to travel up to 20% of the time domestically and internationally.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"508f4c76-d3bf-42f9-9f29-516fd2e7423f","title":"Senior Manager, Trial Operations","department":"Clinical Development","team":"Trial Operations","employmentType":"FullTime","location":"Vancouver","secondaryLocations":[],"publishedAt":"2026-08-18T14:42:52.393+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"British Columbia","addressCountry":"Canada","addressLocality":"Burnaby"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/508f4c76-d3bf-42f9-9f29-516fd2e7423f","applyUrl":"https://jobs.ashbyhq.com/xenon/508f4c76-d3bf-42f9-9f29-516fd2e7423f/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Senior Manager, Trial Operations to join our team. This is a strategic yet hands-on clinical operations role that is responsible for the successful delivery of Phase 3 clinical trials, overseeing activities from study start-up through closeout. The Senior Manager will partner closely with Clinical Development, Clinical Science, CMC, Regulatory Affairs, and external vendors, to drive trial strategy and execution to ensure high-quality study delivery against the plan.

The role is instrumental in overall vendor selection and management, site feasibility and start-up planning, budget and timeline management, and proactive risk identification and mitigation. The successful candidate will bring deep clinical operations expertise, strong project management and organization capabilities, and a proven ability to lead cross-functional teams and external partners in achieving critical program objectives.

This position reports to the Director, Trial Operations, and will be based out of our Vancouver, BC office. We may consider remote locations for exceptional candidates. This is a Hybrid position requiring a minimum of two onsite days per week.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Senior Manager, Trial Operations to join our team. This is a strategic yet hands-on clinical operations role that is responsible for the successful delivery of Phase 3 clinical trials, overseeing activities from study start-up through closeout. The Senior Manager will partner closely with Clinical Development, Clinical Science, CMC, Regulatory Affairs, and external vendors, to drive trial strategy and execution to ensure high-quality study delivery against the plan.\n\nThe role is instrumental in overall vendor selection and management, site feasibility and start-up planning, budget and timeline management, and proactive risk identification and mitigation. The successful candidate will bring deep clinical operations expertise, strong project management and organization capabilities, and a proven ability to lead cross-functional teams and external partners in achieving critical program objectives.\n\nThis position reports to the Director, Trial Operations, and will be based out of our Vancouver, BC office. We may consider remote locations for exceptional candidates. This is a Hybrid position requiring a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\n - Provide clinical trial management leadership for multiple Phase 3 clinical trials , across therapeutic areas.\n\n - Collaborate with cross-functional team members to ensure highly integrated plans and documents for clinical trials.\n\n - Develop, propose, review and manage plans for assigned studies and activities.\n\n - Lead the preparation of Requests for Proposals (RFPs) in collaboration with other internal team members, coordinate the evaluation of proposals and provide input into the selection and contracting of Contract Research Organizations (CRO) and other clinical service providers.\n\n - Manage contracted service providers to deliver against the contracts.\n\n - Lead the selection of qualified investigators and study sites in collaboration with the Clinical Development team.\n\n - Review and oversee study budgets and invoices to ensure vendors are invoicing in accordance with their contracts.\n\n - Develop and manage study timeline and study metrics cross-functionally.\n\n - Conduct risk assessments, mitigation strategies and contingency planning.\n\n - Communicate with internal/external teams to proactively recognize challenges and risks and work cross-functionally on strategies to mitigate/resolve.\n\n - Actively participate and lead activities in all aspects of clinical trial operations, including the coordination, writing, review and/or finalization of clinical trial protocols, consent forms, case report forms, study plans, safety reviews and other essential regulatory documents.\n\n - Train and mentor new staff or peer mentorship of new hires.\n\n - Actively participates in documentation, sharing and implementation of trial conduct best practices and lessons learned with junior staff.\n\n - Oversee adherence to applicable regulations, recognized guidelines, clinical trial protocol, and standards of clinical practice.\n\n - Participate in the development and updating of standard operating procedures as required.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics.\n\n - Other duties as assigned.\n\nQUALIFICATIONS:\n\n - A minimum bachelor’s degree in a scientific discipline and/or other healthcare designation (e.g., RN).\n\n - A minimum of 5-8 years clinical project/study management experience within the pharmaceutical and/or biotechnology/biopharmaceutical industry or at a CRO. Job level will be commensurate with experience.\n\n - Strong proven experience in trial operations oversight, rollout for Phase 3 studies in related therapeutic areas\n\n - Ability to lead cross-functional team through all activities in the full clinical study life cycle.\n\n - Strong vendor management skills (including CRO) and experience managing outsourced work.\n\n - A good understanding of all phases of the drug development process and the interdependencies between Clinical and other functional areas (e.g., CMC, nonclinical/toxicology, Regulatory Affairs etc.), with specific experience in phase 3 clinical trials. .\n\n - Demonstrated ability to successfully work across a variety of teams and manage multiple conflicting priorities.\n\n - Demonstrated ability to successfully manage and deliver on critical milestones in the successful completion of clinical trials on time and within budget.\n\n - Strong knowledge and understanding of ICH/GCP and US and Canadian regulatory environments; a comprehensive understanding of clinical trial regulations across multiple jurisdictions with previous experience with CTA and IND submissions preferred.\n\n - Excellent oral and written communication skills.\n\n - Strong interpersonal skills and ability to foster strong collaborative relationships with internal and external team members.\n\n - Ability to work both independently and collaboratively as part of a multidisciplinary team.\n\n - Exceptional attention to detail and excellent organizational skills.\n\n - Ability to thrive in a dynamic and fast-paced environment.\n\n - Ability to prioritize duties and manage multiple matters from start to finish with minimal supervision and with a demonstrated ability to lead change and make independent decisions.\n\n - Ability to handle highly confidential and sensitive materials and information with complete discretion.\n\n - Ability and willingness to travel 5-10% of the time (internationally and domestic)\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"c01f9ee1-678a-4f85-a0ec-22ad6e5f1ba1","title":"Senior Manager, Trial Operations","department":"Clinical Development","team":"Trial Operations","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-19T17:57:17.361+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/c01f9ee1-678a-4f85-a0ec-22ad6e5f1ba1","applyUrl":"https://jobs.ashbyhq.com/xenon/c01f9ee1-678a-4f85-a0ec-22ad6e5f1ba1/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Senior Manager, Trial Operations to join our team. This is a strategic yet hands-on clinical operations role that is responsible for the successful delivery of Phase 3 clinical trials, overseeing activities from study start-up through closeout. The Senior Manager will partner closely with Clinical Development, Clinical Science, CMC, Regulatory Affairs, and external vendors, to drive trial strategy and execution to ensure high-quality study delivery against the plan.

The role is instrumental in overall vendor selection and management, site feasibility and start-up planning, budget and timeline management, and proactive risk identification and mitigation. The successful candidate will bring deep clinical operations expertise, strong project management and organization capabilities, and a proven ability to lead cross-functional teams and external partners in achieving critical program objectives.

This position reports to the Director, Trial Operations, and will be based out of Boston, MA, USA in our Needham office. We may consider remote locations for exceptional candidates. This is a Hybrid position requiring a minimum of two onsite days per week.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Senior Manager, Trial Operations to join our team. This is a strategic yet hands-on clinical operations role that is responsible for the successful delivery of Phase 3 clinical trials, overseeing activities from study start-up through closeout. The Senior Manager will partner closely with Clinical Development, Clinical Science, CMC, Regulatory Affairs, and external vendors, to drive trial strategy and execution to ensure high-quality study delivery against the plan.\n\nThe role is instrumental in overall vendor selection and management, site feasibility and start-up planning, budget and timeline management, and proactive risk identification and mitigation. The successful candidate will bring deep clinical operations expertise, strong project management and organization capabilities, and a proven ability to lead cross-functional teams and external partners in achieving critical program objectives.\n\nThis position reports to the Director, Trial Operations, and will be based out of Boston, MA, USA in our Needham office. We may consider remote locations for exceptional candidates. This is a Hybrid position requiring a minimum of two onsite days per week.\n\nRESPONSIBILITIES:\n\n - Provide clinical trial management leadership for multiple Phase 3 clinical trials , across therapeutic areas.\n\n - Collaborate with cross-functional team members to ensure highly integrated plans and documents for clinical trials.\n\n - Develop, propose, review and manage plans for assigned studies and activities.\n\n - Lead the preparation of Requests for Proposals (RFPs) in collaboration with other internal team members, coordinate the evaluation of proposals and provide input into the selection and contracting of Contract Research Organizations (CRO) and other clinical service providers.\n\n - Manage contracted service providers to deliver against the contracts.\n\n - Lead the selection of qualified investigators and study sites in collaboration with the Clinical Development team.\n\n - Review and oversee study budgets and invoices to ensure vendors are invoicing in accordance with their contracts.\n\n - Develop and manage study timeline and study metrics cross-functionally.\n\n - Conduct risk assessments, mitigation strategies and contingency planning.\n\n - Communicate with internal/external teams to proactively recognize challenges and risks and work cross-functionally on strategies to mitigate/resolve.\n\n - Actively participate and lead activities in all aspects of clinical trial operations, including the coordination, writing, review and/or finalization of clinical trial protocols, consent forms, case report forms, study plans, safety reviews and other essential regulatory documents.\n\n - Train and mentor new staff or peer mentorship of new hires.\n\n - Actively participates in documentation, sharing and implementation of trial conduct best practices and lessons learned with junior staff.\n\n - Oversee adherence to applicable regulations, recognized guidelines, clinical trial protocol, and standards of clinical practice.\n\n - Participate in the development and updating of standard operating procedures as required.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics.\n\n - Other duties as assigned.\n\nQUALIFICATIONS:\n\n - A minimum bachelor’s degree in a scientific discipline and/or other healthcare designation (e.g., RN).\n\n - A minimum of 5-8 years clinical project/study management experience within the pharmaceutical and/or biotechnology/biopharmaceutical industry or at a CRO. Job level will be commensurate with experience.\n\n - Strong proven experience in trial operations oversight, rollout for Phase 3 studies in related therapeutic areas\n\n - Ability to lead cross-functional team through all activities in the full clinical study life cycle.\n\n - Strong vendor management skills (including CRO) and experience managing outsourced work.\n\n - A good understanding of all phases of the drug development process and the interdependencies between Clinical and other functional areas (e.g., CMC, nonclinical/toxicology, Regulatory Affairs etc.), with specific experience in phase 3 clinical trials. .\n\n - Demonstrated ability to successfully work across a variety of teams and manage multiple conflicting priorities.\n\n - Demonstrated ability to successfully manage and deliver on critical milestones in the successful completion of clinical trials on time and within budget.\n\n - Strong knowledge and understanding of ICH/GCP and US and Canadian regulatory environments; a comprehensive understanding of clinical trial regulations across multiple jurisdictions with previous experience with CTA and IND submissions preferred.\n\n - Excellent oral and written communication skills.\n\n - Strong interpersonal skills and ability to foster strong collaborative relationships with internal and external team members.\n\n - Ability to work both independently and collaboratively as part of a multidisciplinary team.\n\n - Exceptional attention to detail and excellent organizational skills.\n\n - Ability to thrive in a dynamic and fast-paced environment.\n\n - Ability to prioritize duties and manage multiple matters from start to finish with minimal supervision and with a demonstrated ability to lead change and make independent decisions.\n\n - Ability to handle highly confidential and sensitive materials and information with complete discretion.\n\n - Ability and willingness to travel 5-10% of the time (internationally and domestic)\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"508cb232-aabd-4c86-a5f7-9d2b32dce3df","title":"Principal Engineer, Enterprise Data Integration / Associate Director","department":"General & Administration","team":"Information Technology","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-21T18:58:30.225+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/508cb232-aabd-4c86-a5f7-9d2b32dce3df","applyUrl":"https://jobs.ashbyhq.com/xenon/508cb232-aabd-4c86-a5f7-9d2b32dce3df/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking a Principal Engineer, Enterprise Data Integration, to join our Information Technology (IT) team. The position will help lead the design, implementation, and ongoing operation of Xenon’s enterprise integration, middleware, and data engineering capabilities. This individual will partner with leaders across IT, Commercial, Medical, Finance, Supply Chain, Clinical Development, Research, and Quality, and external partners to establish scalable, secure, and compliant data flows across Xenon’s enterprise application and analytics ecosystem.

This role will be a key enabler of Xenon’s growth and commercialization readiness, helping connect core platforms such as ERP, CRM, data warehouse, master data management, clinical and research systems, quality systems, and external partner networks. The successful candidate will combine strong hands-on technical depth with strong architecture, governance, vendor management, and cross-functional leadership skills.

This position reports to the Director, Data Architecture & Engineering and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office.

RESPONSIBILITIES:

QUALIFICATIONS:

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking a Principal Engineer, Enterprise Data Integration, to join our Information Technology (IT) team. The position will help lead the design, implementation, and ongoing operation of Xenon’s enterprise integration, middleware, and data engineering capabilities. This individual will partner with leaders across IT, Commercial, Medical, Finance, Supply Chain, Clinical Development, Research, and Quality, and external partners to establish scalable, secure, and compliant data flows across Xenon’s enterprise application and analytics ecosystem.\n\nThis role will be a key enabler of Xenon’s growth and commercialization readiness, helping connect core platforms such as ERP, CRM, data warehouse, master data management, clinical and research systems, quality systems, and external partner networks. The successful candidate will combine strong hands-on technical depth with strong architecture, governance, vendor management, and cross-functional leadership skills.\n\nThis position reports to the Director, Data Architecture & Engineering and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office.\n\n\n\nRESPONSIBILITIES:\n\n - Manage the implementation and maturation of Xenon’s enterprise integration and data engineering capabilities, including middleware/iPaaS, API-based integration, event/message-based integration, file-based ingestion, and ELT/data pipeline patterns.\n\n - Partner with IT and business leaders to define and maintain an enterprise integration roadmap aligned to ERP, Commercial, Medical, Clinical, Research, Quality, MDM, and data warehouse priorities.\n\n - In consultation with assigned stakeholders, evaluate, select, implement, and govern integration and ELT platforms such as Informatica/IICS, Boomi, MuleSoft, Azure Integration Services, Fivetran, dbt, Snowflake, or similar technologies.\n\n - Design and oversee integrations and data pipelines between internal and external systems including ERP, Veeva CRM/Vault, commercial data providers, patient services platforms, EDC/clinical systems, safety systems, LIMS, eQMS, Dotmatics/ELN, HRIS/HCM, CLM, Concur, Adaptive Planning, banks, CDMOs/CMOs, 3PLs, and other partners.\n\n - Establish reusable integration standards, data contracts, interface specifications, transformation patterns, naming conventions, monitoring/alerting practices, runbooks, and documentation standards.\n\n - Collaborate with Xenon’s Architecture Review Board to ensure system and data-flow designs are consistent with company standards for security, infrastructure, data architecture, privacy, and operational supportability.\n\n - Partner with business data owners and data stewards to establish and maintain effective data governance including master data management, data quality, metadata, lineage, cataloging, access controls, and common data definitions across domains.\n\n - Provide technical leadership for data models, ELT transformations, curated data layers, and “gold” datasets that enable trusted analytics, self-service reporting, AI/ML, and operational decision-making.\n\n - Ensure integration and data engineering solutions are designed with appropriate controls for GxP, SOX, HIPAA, GDPR, 21 CFR Part 11, auditability, data integrity, and role-based access, as applicable.\n\n - Provide technical guidance and support for Computer Systems Assurance (CSA), SDLC, regulatory/risk assessment, testing, validation, and change control deliverables for regulated systems and data flows.\n\n - Develop and manage the ongoing support model for integrations and data pipelines, including onboarding and managing qualified implementation partners and service providers.\n\n - Ensure ongoing compliance with Xenon procedures including Change Management, Incident Management, Problem Management, SaaS Release Management, and other applicable IT operating processes.\n\n - Monitor integration and pipeline performance, manage operational issues to resolution, drive root cause analysis, and lead continuous improvement of platform reliability, scalability, cost efficiency, and support processes.\n\n - Translate business requirements into practical integration architecture, technical design, delivery plans, test strategies, and sustainable operating procedures.\n\n - Lead, mentor, or coordinate internal and external data engineers, integration developers, analysts, and vendor resources as the capability grows.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics, and ensure policies are understood and followed by direct reports, if any.\n\n - Some international travel may be required.\n\n - Other duties as assigned.\n\nQUALIFICATIONS:\n\n - A bachelor’s degree or advanced degree in Information Systems, Computer Science, Data Engineering, Engineering, Business Administration, with a minimum of 7-10 years prior experience with enterprise integration, data engineering, middleware, cloud data platform, analytics platform, or enterprise applications\n\n - Experience in Life Sciences, pharmaceutical, biotechnology, healthcare, or another regulated industry is preferred. Direct pharma/biotech experience is an asset but not required\n\n - Proven experience designing and delivering enterprise integrations, API integrations, batch/file-based interfaces, ELT/ETL pipelines, data orchestration, data quality checks, monitoring, and production support processes.\n\n - Hands-on experience with one or more integration or data platforms such as Informatica/IICS, Boomi, MuleSoft, Azure Integration Services, Fivetran, dbt, Snowflake, Databricks, or similar technologies.\n\n - Strong understanding of cloud data warehouse and analytics architectures, including source-to-target mapping, transformation logic, curated data layers, semantic models, and BI/analytics consumption patterns.\n\n - Experience with data governance, master data management, stewardship, metadata, lineage, cataloging, and data quality practices; MDM platform implementation experience is an asset.\n\n - Experience integrating enterprise SaaS platforms and life-sciences systems such as ERP (Oracle Fusion or SAP S/4HANA), Veeva, Workday/HCM, CLM, Concur, Adaptive Planning, ServiceNow, eQMS, LIMS, EDC, ELN, clinical data repositories, or commercial data platforms.\n\n - Experience with Computer Systems Assurance, GxP systems validation, SDLC, 21 CFR Part 11, HIPAA, GDPR, SOX, audit trails, data integrity, and role-based access controls is preferred.\n\n - Ability to balance strategic architecture with pragmatic delivery in a growing, fast-paced organization; comfortable building capability, standards, and operating models from the ground up.\n\n - Experience managing external consultants, implementation partners, managed service providers, and/or application service providers.\n\n - Excellent communication and coordination skills across business, technical, Quality, Security, and vendor teams.\n\n - Ability to manage multiple priorities, lead through ambiguity, and drive decisions with appropriate documentation and stakeholder alignment.\n\n - Strong problem-solving skills, attention to detail, and ability to simplify complex technical concepts for non-technical audiences.\n\n - Project management experience; Agile, PMP, ITIL, cloud, data, or integration platform certifications are a plus.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."},{"id":"a69d4749-02cd-4ba6-94b1-066ef565341b","title":"Associate Director/Director, Development Program Management, CMC","department":"R&D Operations","team":"Development Program Management","employmentType":"FullTime","location":"Boston","secondaryLocations":[],"publishedAt":"2026-08-26T22:07:11.623+00:00","isListed":true,"isRemote":true,"workplaceType":"Hybrid","address":{"postalAddress":{"addressRegion":"Massachusetts","addressCountry":"United States","addressLocality":"Needham"}},"jobUrl":"https://jobs.ashbyhq.com/xenon/a69d4749-02cd-4ba6-94b1-066ef565341b","applyUrl":"https://jobs.ashbyhq.com/xenon/a69d4749-02cd-4ba6-94b1-066ef565341b/application","descriptionHtml":"

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking an Associate Director/Director, Development Program Management, CMC to join our team. The Associate Director/Director, Development Program Management, CMC will provide strategic and operational project management leadership for CMC teams, with an initial focus on phase 1 and 2 compounds. This role will drive integrated planning, execution support, governance, and communication across multiple cross-functional programs and initiatives.

The successful candidate will partner closely with CMC and program stakeholders to translate strategy into clear, actionable execution plans; maintain high-quality project plans, dashboards, milestone trackers, risk and action logs; and ensure timely follow-up on key deliverables, decisions, dependencies, and risks. The role will also help strengthen project management practices through scalable tools, clear meeting governance, financial tracking, continuous improvement, and appropriate use of emerging technologies.

This position reports to the Senior Vice President, Portfolio and Alliance Management and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

QUALIFICATIONS

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

","descriptionPlain":"Who We Are:\n\nXenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.\n\nWhat We Do:\n\nWe are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.\n\nAbout the Role:\n\nWe are seeking an Associate Director/Director, Development Program Management, CMC to join our team. The Associate Director/Director, Development Program Management, CMC will provide strategic and operational project management leadership for CMC teams, with an initial focus on phase 1 and 2 compounds. This role will drive integrated planning, execution support, governance, and communication across multiple cross-functional programs and initiatives. \n\nThe successful candidate will partner closely with CMC and program stakeholders to translate strategy into clear, actionable execution plans; maintain high-quality project plans, dashboards, milestone trackers, risk and action logs; and ensure timely follow-up on key deliverables, decisions, dependencies, and risks. The role will also help strengthen project management practices through scalable tools, clear meeting governance, financial tracking, continuous improvement, and appropriate use of emerging technologies.\n\nThis position reports to the Senior Vice President, Portfolio and Alliance Management and will be based out of Boston, MA, USA in our Needham office. We will consider remote locations for exceptional candidates. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. \n\n\n\nRESPONSIBILITIES:\n\n - Plan and manage budget proposals and approved budgets in accordance with the Company’s strategic and operating plans and Finance policies. Partner with CMC, Development Program Management, Program Team Leaders, and functional stakeholders to translate program strategy into integrated CMC execution plans, project charters, and team ways of working for assigned programs and initiatives.\n\n - Lead project management for assigned CMC activities, including new molecules, tech transfer, scale-up, lifecycle management, and other development initiatives, ensuring alignment of scope, timelines, milestones, dependencies, deliverables, and risks.\n\n - Develop, baseline, and maintain project management tools and reporting, including CMC project plans, dashboards, milestone charts, action logs, risk logs, status reports, and financial tracking, as appropriate.\n\n - Drive team execution and governance through effective meeting management, decision and action documentation, follow-up with accountable owners, and clear communication of progress, risks, issues, and key decisions.\n\n - Monitor project progress, identify risks or execution gaps, and partner with stakeholders to develop mitigation plans, escalation recommendations, and decision-ready updates.\n\n - Improve CMC project management effectiveness through scalable tools, templates, Smartsheet solutions, automation, AI-enabled approaches, and other process improvements that enhance planning, visibility, and execution.\n\n - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.\n\n - Some international travel may be required.\n\n - Other duties as assigned.\n\n\n\nQUALIFICATIONS\n\n - Bachelor’s degree in a scientific, technical, business, or related discipline required; advanced degree preferred.\n\n - Typically requires 8+ years of relevant biotechnology or pharmaceutical industry experience for Associate Director level, or 10+ years for Director level, including significant experience in CMC, pharmaceutical development, technical operations, or related drug development environments.\n\n - Experience supporting small molecule drug substance and drug product development required; experience with API development and solid oral dosage forms strongly preferred.\n\n - Demonstrated experience managing cross-functional CMC deliverables, timelines, risks, and documentation in support of early-stage regulatory submissions, including INDs and/or IMPDs; exposure to NDA/MAA or other late-stage submission activities preferred.\n\n - Proven ability to influence without authority, drive alignment across technical and non-technical stakeholders, and ensure execution discipline across complex, matrixed development teams.\n\n - Experience developing and maintaining CMC-specific project plans, dashboards, milestone charts, action logs, risk logs, and related project management tools.\n\n - Strong analytical, facilitation, problem-solving, written communication, and verbal communication skills, with the ability to communicate effectively with both technical and non-technical stakeholders.\n\n - Proficiency with Smartsheet, Microsoft Project, Microsoft Office, and related project management tools required.\n\n - PMP certification or equivalent project management training preferred.\n\nOur Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.\n\nXenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees."}],"apiVersion":"1"}